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Related Collections Immunobiology Apoptosis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 December 2000, Vol. 96, No. 13, pp. 4300-4306 IMMUNOBIOLOGY The long pentraxin PTX3 binds to apoptotic cells and regulates their clearance by antigen-presenting dendritic cells Patrizia Rovere, Giuseppe Peri, Fausto Fazzini, Barbara Bottazzi, Andrea Doni, Attilio Bondanza, Valérie S. Zimmermann, Cecilia Garlanda, Umberto Fascio, Maria Grazia Sabbadini, Claudio Rugarli, Alberto Mantovani, and Angelo A. Manfredi From the Tumor Immunology Laboratory and Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H S. Raffaele and Vita-Salute San Raffaele University; Department of Biology, University of Milan and Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy; and the Sezione di Patologia e Immunologia, Dipartimento di Biotecnologie, Università di Brescia, Brescia, Italy. Pentraxins are acute-phase proteins produced in vivo during inflammatory reactions. Classical short pentraxins, C-reactive protein, and serum amyloid P component are generated in the liver in response to interleukin (IL)-6. The long pentraxin PTX3 is produced in tissues under the control of primary proinflammatory signals, such as lipopolysaccharide, IL-1, and tumor necrosis factor-, which also promote maturation of dendritic cells (DCs). Cell death commonly occurs during inflammatory reactions. In this study, it is shown that PTX3 specifically binds to dying cells. The binding was dose dependent and saturable. Recognition was restricted to extranuclear membrane domains and to a chronological window after UV irradiation or after CD95 cross-linking-induced or spontaneous cell death in vitro. PTX3 bound to necrotic cells to a lesser extent. Human DCs failed to internalize dying cells in the presence of PTX3, while they took up normally soluble or inert particulate substrates. 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Peri, V. Russo, A. Mantovani, A. A. Manfredi, and P. Rovere-Querini The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells J. Leukoc. Biol., July 1, 2006; 80(1): 87 - 95. [Abstract] [Full Text] [PDF] E. F. Vernon-Wilson, F. Aurade, and S. B. Brown CD31 promotes {beta}1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin J. Leukoc. Biol., June 1, 2006; 79(6): 1260 - 1267. [Abstract] [Full Text] [PDF] B. Bottazzi, A. Bastone, A. Doni, C. Garlanda, S. Valentino, L. Deban, V. Maina, A. Cotena, F. Moalli, L. Vago, et al. The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility J. Leukoc. Biol., May 1, 2006; 79(5): 909 - 912. 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Franz, A. Sheriff, R. E. Voll, J. R. Kalden, and M. Herrmann SLE--a disease of clearance deficiency? Rheumatology, September 1, 2005; 44(9): 1101 - 1107. [Abstract] [Full Text] [PDF] C. J. G. de Almeida, L. B. Chiarini, J. P. da Silva, P. M. R. e Silva, M. A. Martins, and R. Linden The cellular prion protein modulates phagocytosis and inflammatory response J. Leukoc. Biol., February 1, 2005; 77(2): 238 - 246. [Abstract] [Full Text] [PDF] R. Latini, A. P. Maggioni, G. Peri, L. Gonzini, D. Lucci, P. Mocarelli, L. Vago, F. Pasqualini, S. Signorini, D. Soldateschi, et al. Prognostic Significance of the Long Pentraxin PTX3 in Acute Myocardial Infarction Circulation, October 19, 2004; 110(16): 2349 - 2354. [Abstract] [Full Text] [PDF] M Bijl, H Bootsma, Y van der Geld, P C Limburg, C G M Kallenberg, and M H van Rijswijk Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction Ann Rheum Dis, July 1, 2004; 63(7): 831 - 835. [Abstract] [Full Text] [PDF] M. Rusnati, M. Camozzi, E. Moroni, B. Bottazzi, G. Peri, S. Indraccolo, A. Amadori, A. Mantovani, and M. Presta Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis Blood, July 1, 2004; 104(1): 92 - 99. [Abstract] [Full Text] [PDF] G. Brouckaert, M. Kalai, D. V. Krysko, X. Saelens, D. Vercammen, `M. Ndlovu, G. Haegeman, K. D'Herde, and P. Vandenabeele Phagocytosis of Necrotic Cells by Macrophages Is Phosphatidylserine Dependent and Does Not Induce Inflammatory Cytokine Production Mol. Biol. Cell, March 1, 2004; 15(3): 1089 - 1100. [Abstract] [Full Text] [PDF] S. P. Hart, K. M. Alexander, and I. 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