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Related Collections Neoplasia Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 December 2000, Vol. 96, No. 13, pp. 4319-4327 NEOPLASIA Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway Ren-Yuan Bai, Tao Ouyang, Cornelius Miething, Stephan W. Morris, Christian Peschel, and Justus Duyster From the Department of Internal Medicine III, Laboratory of Leukemogenesis, Technical University of Munich, Germany; and the Department of Pathology, St Jude Children's Research Hospital, Memphis, TN. More than half of anaplastic large-cell lymphomas (ALCLs) have a chromosomal translocation t(2;5) that leads to the expression of a hybrid protein composed of the nucleolar phosphoprotein nucleophosmin (NPM) and the anaplastic lymphoma kinase (ALK) that exhibits an unregulated tyrosine kinase activity. We have previously identified PLC- as a crucial downstream signaling molecule of NPM-ALK that contributes to its mitogenic potential. Here, we show that NPM-ALK recruits the C-terminal SH2 domain of the phosphatidylinositol 3-kinase (PI 3kinase) p85 subunit. PI 3-kinase assays revealed that the kinase is activated by NPM-ALK in vivo, in turn activating PKB/Akt in NPM-ALK-expressing cells. The use of 2 specific PI 3-kinase inhibitors, wortmannin and LY294002, demonstrated the requirement of PI 3-kinase for the growth of NPM-ALK-transformed cell lines, as well as a cell line established from a patient with ALCL. Primary murine bone marrow retrovirally transduced with NPM-ALK showed a transformed phenotype that was reversible on treatment with PI 3-kinase inhibitors. Flow cytometric analysis revealed that wortmannin-treated NPM-ALK-transformed cell lines underwent apoptosis. Furthermore, apoptosis induced by overexpression of the proapoptotic molecule Bad could be partially blocked by the overexpression of NPM-ALK. Thus, NPM-ALK activates the antiapoptotic PI 3-kinase/Akt pathway, which likely contributes to the molecular pathogenesis of ALCL. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. P. Mosse, A. Wood, and J. M. Maris Inhibition of ALK Signaling for Cancer Therapy Clin. Cancer Res., September 15, 2009; 15(18): 5609 - 5614. [Abstract] [Full Text] [PDF] M. S. Lim, M. L. Carlson, D. K. Crockett, G. C. Fillmore, D. R. Abbott, O. F. Elenitoba-Johnson, S. R. Tripp, G. Z. Rassidakis, L. J. Medeiros, P. Szankasi, et al. The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways Blood, August 20, 2009; 114(8): 1585 - 1595. [Abstract] [Full Text] [PDF] Y.-X. Cui, A. Kerby, F. K. E. McDuff, H. 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Duyster Inhibition of Wild-Type and Mutant Bcr-Abl by Pyrido-Pyrimidine-Type Small Molecule Kinase Inhibitors Cancer Res., October 1, 2003; 63(19): 6395 - 6404. [Abstract] [Full Text] [PDF] L. Wohlbold, H. van der Kuip, C. Miething, H.-P. Vornlocher, C. Knabbe, J. Duyster, and W. E. Aulitzky Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571) Blood, September 15, 2003; 102(6): 2236 - 2239. [Abstract] [Full Text] [PDF] J. D. Khoury, L. J. Medeiros, G. Z. Rassidakis, M. A. Yared, P. Tsioli, V. Leventaki, A. Schmitt-Graeff, M. Herling, H. M. Amin, and R. Lai Differential Expression and Clinical Significance of Tyrosine-phosphorylated STAT3 in ALK+ and ALK- Anaplastic Large Cell Lymphoma Clin. Cancer Res., September 1, 2003; 9(10): 3692 - 3699. [Abstract] [Full Text] [PDF] T. Ouyang, R.-Y. Bai, F. Bassermann, C. von Klitzing, S. Klumpen, C. Miething, S. W. Morris, C. Peschel, and J. Duyster Identification and Characterization of a Nuclear Interacting Partner of Anaplastic Lymphoma Kinase (NIPA) J. Biol. Chem., August 8, 2003; 278(32): 30028 - 30036. [Abstract] [Full Text] [PDF] M. Nishikori, Y. Maesako, C. Ueda, M. Kurata, T. Uchiyama, and H. Ohno High-level expression of BCL3 differentiates t(2;5)(p23;q35)-positive anaplastic large cell lymphoma from Hodgkin disease Blood, April 1, 2003; 101(7): 2789 - 2796. [Abstract] [Full Text] [PDF] R. Chiarle, J. Z. Gong, I. Guasparri, A. Pesci, J. Cai, J. Liu, W. J. Simmons, G. Dhall, J. Howes, R. Piva, et al. NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors Blood, March 1, 2003; 101(5): 1919 - 1927. [Abstract] [Full Text] [PDF] F. Ravandi, M. Talpaz, and Z. Estrov Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies Clin. Cancer Res., February 1, 2003; 9(2): 535 - 550. [Abstract] [Full Text] [PDF] E. T. Bowden, G. E. Stoica, and A. Wellstein Anti-apoptotic Signaling of Pleiotrophin through Its Receptor, Anaplastic Lymphoma Kinase J. Biol. Chem., September 20, 2002; 277(39): 35862 - 35868. [Abstract] [Full Text] [PDF] J. L. Kutok and J. C. Aster Molecular Biology of Anaplastic Lymphoma Kinase-Positive Anaplastic Large-Cell Lymphoma J. Clin. Oncol., September 1, 2002; 20(17): 3691 - 3702. [Abstract] [Full Text] [PDF] E. A. Raetz, S. L. Perkins, M. A. Carlson, K. P. Schooler, W. L. Carroll, and D. M. Virshup The Nucleophosmin-Anaplastic Lymphoma Kinase Fusion Protein Induces c-Myc Expression in Pediatric Anaplastic Large Cell Lymphomas Am. J. Pathol., September 1, 2002; 161(3): 875 - 883. [Abstract] [Full Text] [PDF] G. Piccinini, R. Bacchiocchi, M. Serresi, C. Vivani, S. Rossetti, C. Gennaretti, D. Carbonari, and F. Fazioli A Ligand-inducible Epidermal Growth Factor Receptor/Anaplastic Lymphoma Kinase Chimera Promotes Mitogenesis and Transforming Properties in 3T3 Cells J. Biol. Chem., June 14, 2002; 277(25): 22231 - 22239. [Abstract] [Full Text] [PDF] R. L. ten Berge, C. J. L. M. Meijer, D. F. Dukers, J. A. Kummer, B. A. Bladergroen, W. Vos, C. E. Hack, G. J. Ossenkoppele, and J. J. Oudejans Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma Blood, May 29, 2002; 99(12): 4540 - 4546. [Abstract] [Full Text] [PDF] L. Hernandez, S. Bea, B. Bellosillo, M. Pinyol, B. Falini, A. Carbone, G. Ott, A. Rosenwald, A. Fernandez, K. Pulford, et al. Diversity of Genomic Breakpoints in TFG-ALK Translocations in Anaplastic Large Cell Lymphomas : Identification of a New TFG-ALKXL Chimeric Gene with Transforming Activity Am. J. Pathol., April 1, 2002; 160(4): 1487 - 1494. [Abstract] [Full Text] [PDF] F. Bassermann, T. Jahn, C. Miething, P. Seipel, R.-Y. Bai, S. Coutinho, V. L. Tybulewicz, C. Peschel, and J. Duyster Association of Bcr-Abl with the Proto-oncogene Vav Is Implicated in Activation of the Rac-1 Pathway J. Biol. Chem., March 29, 2002; 277(14): 12437 - 12445. [Abstract] [Full Text] [PDF] L. Passoni, A. Scardino, C. Bertazzoli, B. Gallo, A. M. L. Coluccia, F. A. Lemonnier, K. Kosmatopoulos, and C. Gambacorti-Passerini ALK as a novel lymphoma-associated tumor antigen: identification of 2 HLA-A2.1-restricted CD8+ T-cell epitopes Blood, March 15, 2002; 99(6): 2100 - 2106. [Abstract] [Full Text] [PDF] P. Bonvini, T. Gastaldi, B. Falini, and A. Rosolen Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK), a Novel Hsp90-Client Tyrosine Kinase: Down-Regulation of NPM-ALK Expression and Tyrosine Phosphorylation in ALK+ CD30+ Lymphoma Cells by the Hsp90 Antagonist 17-Allylamino,17-demethoxygeldanamycin Cancer Res., March 1, 2002; 62(5): 1559 - 1566. [Abstract] [Full Text] [PDF] J. Dierov, Q. Xu, R. Dierova, and M. Carroll TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle Blood, March 1, 2002; 99(5): 1758 - 1765. [Abstract] [Full Text] [PDF] F. Turturro, M. D. Arnold, A. Y. Frist, and K. Pulford Model of Inhibition of the NPM-ALK Kinase Activity by Herbimycin A Clin. Cancer Res., January 1, 2002; 8(1): 240 - 245. [Abstract] [Full Text] [PDF] Q. Zhang, P. N. Raghunath, L. Xue, M. Majewski, D. F. Carpentieri, N. Odum, S. Morris, T. Skorski, and M. A. Wasik Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma J. Immunol., January 1, 2002; 168(1): 466 - 474. [Abstract] [Full Text] [PDF] T. Jahn, P. Seipel, S. Coutinho, C. Miething, C. Peschel, and J. Duyster Grb4/Nckbeta Acts as a Nuclear Repressor of v-Abl-induced Transcription from c-jun/c-fos Promoter Elements J. Biol. Chem., November 9, 2001; 276(46): 43419 - 43427. [Abstract] [Full Text] [PDF] H. van der Kuip, A. W. Goetz, C. Miething, J. Duyster, and W. E. Aulitzky Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis Blood, September 1, 2001; 98(5): 1532 - 1541. [Abstract] [Full Text] [PDF] M. Sun, J. E. Paciga, R. I. Feldman, Z.-q. Yuan, D. Coppola, Y. Y. Lu, S. A. Shelley, S. V. Nicosia, and J. Q. Cheng Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, Activated in Breast Cancer, Regulates and Is Induced by Estrogen Receptor {alpha} (ER{alpha}) via Interaction between ER{alpha} and PI3K Cancer Res., August 1, 2001; 61(16): 5985 - 5991. [Abstract] [Full Text] [PDF] G. Z. Rassidakis, A. H. Sarris, M. Herling, R. J. Ford, F. Cabanillas, T. J. McDonnell, and L. J. Medeiros Differential Expression of BCL-2 Family Proteins in ALK-Positive and ALK-Negative Anaplastic Large Cell Lymphoma of T/Null-Cell Lineage Am. J. Pathol., August 1, 2001; 159(2): 527 - 535. [Abstract] [Full Text] C. Villalva, F. Bougrine, G. Delsol, and P. Brousset Bcl-2 Expression in Anaplastic Large Cell Lymphoma Am. J. Pathol., May 1, 2001; 158(5): 1889 - 1890. [Full Text] [PDF] M. H.-H. Nguyen, J. M.-Y. Ho, B. K. Beattie, and D. L. Barber TEL-JAK2 Mediates Constitutive Activation of the Phosphatidylinositol 3'-Kinase/Protein Kinase B Signaling Pathway J. Biol. Chem., August 24, 2001; 276(35): 32704 - 32713. [Abstract] [Full Text] [PDF]

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