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Blood, 15 December 2000, Vol. 96, No. 13, pp. 4357-4359

BRIEF REPORT

Frequency and kinetics of polyclonal and clonal B cells in the peripheral blood of patients being treated for multiple myeloma

Thomas Rasmussen, Linda Jensen, Lone Honoré, and Hans Erik Johnsen

From the Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark.

Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact level and phenotype of clonal B cells and their response to treatment. In this report we document that the peripheral blood tumor burden at presentation was reduced by induction therapy to a low level, regardless of the initial tumor burden. However, the residual clonal compartment persisted before and after transplant. The level of clonal cells showed no correlation with CD19+ cell levels. In a single patient with MM, high numbers of phenotypically aberrant clonal cells with altered CD19 expression were identified.

© 2000 by The American Society of Hematology.
 

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Related Letter in Blood Online:

Clonotypic B cells in the peripheral blood of patients with multiple myeloma
Friedrich W. Cremer, Hartmut Goldschmidt, Marion Moos, Thomas Rasmussen, and Hans Erik Johnsen
Blood 2001 97: 2913-2914. [Full Text] [PDF]



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