Blood, Vol. 96 No. 3 (August 1), 2000:
pp. 863-863
ERRATUM
In
the article by Bang et al entitled "Unique processing pathways
within recipient antigen-presenting cells determine IgG immunity
against donor platelet MCH antigens," which appeared in the March 1, 2000, issue of Blood (95:1735-1742), the references for the
second paragraph should read as follows: Two recipient T-cell
recognition mechanisms have been shown to initiate alloimmunity. The
direct pathway occurs when recipient T-helper cells directly interact
with MHC class II molecules on donor APC, whereas the indirect
pathway is analogous to the normal immune response.15-18
Indirect recognition occurs when allogeneic non-APC are administered to
a recipient and involves the processing and presentation of allelic
donor antigens (eg, MHC class I molecules) by recipient APC to
recipient T-helper cells. The indirect pathway of allorecognition has been implicated in rejection responses in various transplantation models of cardiac,17 kidney,18 and
skin1920 grafts. Within the context of indirect
allorecognition, interactions between donor antigen and self-APC are
critical to T-cell activation and subsequent antibody
formation.2122 In 1995, 2 laboratories using different
animal models (murine versus rat) of platelet immunity suggested that
allogeneic platelets stimulated IgG antidonor immunity via indirect
recognition.2324 We subsequently demonstrated that the
indirect alloimmunity against platelets was dependent on the activation
of inducible nitric oxide synthase (iNOS) within recipient
macrophages.25
