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Blood, Vol. 96 No. 3 (August 1), 2000:
pp. 878-884
In vivo generation of human dendritic cell subsets by Flt3 ligand
Eugene Maraskovsky,
Elizabeth Daro,
Eileen Roux,
Mark Teepe,
Charlie R. Maliszewski,
Jeannie Hoek,
Dania Caron,
Mel E. Lebsack, and
Hilary J. McKenna
From Immunex Corporation, Seattle, WA.
Dendritic cells (DCs) represent a family of ontogenically distinct
leukocytes involved in immune response regulation. The ability of DCs
to stimulate T-cell immunity has led to their use as vectors for
immunotherapy vaccines. However, it is unclear whether and to what
degree in vitro-generated DCs are representative of DCs that develop
in vivo. Treatment of mice with human Flt3 ligand (FL) dramatically
increases the number of DCs. We report here that administration of FL
to healthy human volunteers increased the number of circulating
CD11c+ IL-3R low DC (mean 44-fold) and
CD11c IL-3Rhigh DC precursors (mean
12-fold). Moreover, the CD11c+ DCs were efficient
stimulators of T cells in vitro. Thus, FL can expand the number of
circulating, functionally competent human DCs in vivo.
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