|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 August 2000, Vol. 96, No. 4, pp. 1433-1437
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Platelet adhesion to collagen in healthy volunteers is influenced
by variation of both  2 1 density and
von Willebrand factor
Mark Roest,
Jan J. Sixma,
Ya-Ping Wu,
Martin J. W. Ijsseldijk,
Mariëlle Tempelman,
Pieter J. Slootweg,
Philip
G. de Groot, and
G. Henrita van Zanten
From the Laboratory of Thrombosis and Haemostasis,
Department of Hematology, Julius Center for Patient Oriented Research,
and Department of Pathology, University Medical Center Utrecht,
Utrecht, The Netherlands.
Platelet thrombus formation on collagen is initiated by platelet
GPIb interaction with von Willebrand factor (vWF) bound to collagen, followed by firm attachment of the platelet to collagen by
the integrin  2 1. Platelet and plasma vWF
levels and 21 density on the platelet
surface are highly variable among normal subjects; however, little is
known about the consequences of this variability on platelet adhesion
to collagen. A population of 32 normal subjects was studied to evaluate
the relation between genetic and phenotypic variations of
21 density on the platelet surface,
plasma vWF levels, platelet vWF levels, and adenosine diphosphate and
adenosine triphosphate concentrations on the one hand and platelet
adhesion to collagen under flow on the other hand. Platelet adhesion to
collagen types I and III under flow was correlated with plasma levels
of vWF (r2 = 0.45 and 0.42, respectively) and 21 density on the
platelet surface (r2 = 0.35 and
0.17, not significant). Platelet adhesion to collagen type IV under
flow was significantly correlated with platelet vWF levels
(r2 = 0.34) and
21 density on the platelet surface
(r2 = 0.42). Platelet adhesion to
collagen types I and III depends on both plasma levels of vWF and
21 density on the platelet surface,
whereas platelet adhesion to collagen type IV is mediated by both
platelet vWF levels and 21 density on the
platelet surface.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
L. Ostojic, D. Zelenika, R.B. Zotz, C. Sucker, Z. Ostojic, and R. Loncar
Platelet Receptor HPA-1 Polymorphism of {alpha}IIb{beta}3 and 807 C/T Polymorphism of {alpha}2{beta}1 and Buerger's Disease
Angiology,
April 1, 2007;
58(2):
169 - 174.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. V. Gnatenko, P. L. Perrotta, and W. F. Bahou
Proteomic approaches to dissect platelet function: half the story
Blood,
December 15, 2006;
108(13):
3983 - 3991.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ogino, J. Kido, M. Bando, N. Hayashi, C. Wada, T. Nagata, F. Nishimura, Y. Soga, S. Takashiba, T. Kubota, et al.
{alpha}2 Integrin +807 Polymorphism in Drug-induced Gingival Overgrowth
J. Dent. Res.,
December 1, 2005;
84(12):
1183 - 1186.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Ajzenberg, C. Berroeta, I. Philip, B. Grandchamp, P. Ducellier, V. Huart, P. Verpillat, M.-C. Guillin, and J. Benessiano
Association of the -92C/G and 807C/T Polymorphisms of the {alpha}2 Subunit Gene With Human Platelets {alpha}2{beta}1 Receptor Density
Arterioscler. Thromb. Vasc. Biol.,
August 1, 2005;
25(8):
1756 - 1760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R.-M. Siljander, I. C. A. Munnix, P. A. Smethurst, H. Deckmyn, T. Lindhout, W. H. Ouwehand, R. W. Farndale, and J. W. M. Heemskerk
Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood
Blood,
February 15, 2004;
103(4):
1333 - 1341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Smethurst, L. Joutsi-Korhonen, M. N. O'Connor, E. Wilson, N. S. Jennings, S. F. Garner, Y. Zhang, C. G. Knight, T. R. Dafforn, A. Buckle, et al.
Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody
Blood,
February 1, 2004;
103(3):
903 - 911.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lahav, E. M. Wijnen, O. Hess, S. W. Hamaia, D. Griffiths, M. Makris, C. G. Knight, D. W. Essex, and R. W. Farndale
Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin {alpha}2{beta}1
Blood,
September 15, 2003;
102(6):
2085 - 2092.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Joutsi-Korhonen, P. A. Smethurst, A. Rankin, E. Gray, M. IJsseldijk, C. M. Onley, N. A. Watkins, L. M. Williamson, A. H. Goodall, P. G. de Groot, et al.
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression
Blood,
June 1, 2003;
101(11):
4372 - 4379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dupont, P. Fontana, C. Bachelot-Loza, J.-L. Reny, I. Bieche, F. Desvard, M. Aiach, and P. Gaussem
An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN
Blood,
March 1, 2003;
101(5):
1833 - 1840.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Rabbani, N. A. Seminario, R. R. Sciacca, H. J. Chen, and E.-G. V. Giardina
Oral conjugated equine estrogen increases plasma von Willebrand factor in postmenopausal women
J. Am. Coll. Cardiol.,
December 4, 2002;
40(11):
1991 - 1999.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Goel and S. L. Diamond
Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma
Blood,
November 15, 2002;
100(10):
3797 - 3803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Kerrigan, I. Douglas, A. Wray, J. Heath, M. F. Byrne, D. Fitzgerald, and D. Cox
A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation
Blood,
June 28, 2002;
100(2):
509 - 516.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Jacquelin, M. D. Tarantino, M. Kritzik, D. Rozenshteyn, J. A. Koziol, A. T. Nurden, and T. J. Kunicki
Allele-dependent transcriptional regulation of the human integrin {alpha}2 gene
Blood,
March 15, 2001;
97(6):
1721 - 1726.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
