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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Curtis, B. R. Articles by Aster, R. H. Search for Related Content PubMed PubMed Citation Articles by Curtis, B. R. Articles by Aster, R. H. Related Collections Hemostasis, Thrombosis, and Vascular Biology Transfusion Medicine Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 August 2000, Vol. 96, No. 4, pp. 1574-1581 TRANSFUSION MEDICINE Blood group A and B antigens are strongly expressed on platelets of some individuals Brian R. Curtis, Jennifer T. Edwards, Martin J. Hessner, John P. Klein, and Richard H. Aster From the Blood Research Institute, The Blood Center of Southeastern Wisconsin, and the Departments of Medicine, Pathology, and Biostatistics of the Medical College of Wisconsin, Milwaukee, WI. It is widely thought that expression of ABH antigens on platelets is insufficient to materially affect the survival of ABH-incompatible platelets in transfusion recipients, but anecdotal reports of poor survival of A and B mismatched platelets suggest that this is not always the case. The A and B antigen expression on platelets of 100 group A1 and group B blood donors was measured, and 7% and 4%, respectively, had platelets whose A and B antigen levels consistently exceeded the mean plus 2 SD. On the basis of flow cytometric and statistical analysis, donors whose platelets contained higher than normal levels of A antigen were subdivided into 2 groups, designated Type I and Type II ("high expressers"). Serum A1- and B-glycosyltransferase levels of A and B high expressers were significantly higher than those of group A1 and B individuals with normal expression. H antigen levels were low on the red cells of high expressers, indicating that the anomaly affects other cell lineages. Immunochemical studies demonstrated high levels of A antigen on various glycoproteins (GPs) from high-expresser platelets, especially GPIIb and PECAM (CD31). The A1 Type II high-expresser phenotype was inherited as an autosomal dominant trait in one family. The sequences of exons 5, 6, and 7 of the A1-transferase gene of one Type II A1 high expresser and exon 7 from 3 other genes were identical to the reported normal sequences. Further studies are needed to define the molecular basis for the high-expresser trait and to characterize its clinical implications. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. R. Curtis, R. H. Aster, and L. L. Cooling Expression of ABH antigens on platelets Blood, January 15, 2006; 107(2): 842 - 843. [Full Text] [PDF] B. R. Curtis, J. G. McFarland, A. Fick, A. J. Lochowicz, R. H. Ball, and A. H. Richard Neonatal Alloimmune Thrombocytopenia (NATP) Associated with Maternal-Fetal Incompatibility for Blood Group B. Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 955 - 955. [Abstract] L. L. W. Cooling, K. Kelly, J. Barton, D. Hwang, T. A. W. Koerner, and J. D. Olson Determinants of ABH expression on human blood platelets Blood, April 15, 2005; 105(8): 3356 - 3364. [Abstract] [Full Text] [PDF] J. O'Donnell, F. E. Boulton, R. A. Manning, and M. A. Laffan Amount of H Antigen Expressed on Circulating von Willebrand Factor Is Modified by ABO Blood Group Genotype and Is a Major Determinant of Plasma von Willebrand Factor Antigen Levels Arterioscler. Thromb. Vasc. Biol., February 1, 2002; 22(2): 335 - 341. [Abstract] [Full Text] [PDF]

	Copyright © 2000 by American Society of Hematology         Online ISSN: 1528-0020