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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Marshall, C. J. Articles by Thrasher, A. J. Search for Related Content PubMed PubMed Citation Articles by Marshall, C. J. Articles by Thrasher, A. J. Related Collections Hematopoiesis and Stem Cells Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 August 2000, Vol. 96, No. 4, pp. 1591-1593 BRIEF REPORT Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region Caroline J. Marshall, Christine Kinnon, and Adrian J. Thrasher From the Molecular Immunology Unit, Institute of Child Health, London, UK. In the mammal, definitive hematopoietic stem cells (HSCs) are first derived from mesodermal cells within a region of the embryonic para-aortic splanchnopleura known as the aorta-gonad-mesonephros (AGM). Within this region, HSCs are thought to arise from hemangioblast precursors located in the ventral wall of the dorsal aorta. However, the factors that regulate HSC development in vivo are still largely unknown. Bone morphogenetic protein (BMP)-4, a member of the transforming growth factor beta (TGF-) superfamily of growth factors, is a potent ventralizing factor and has been implicated in the commitment of embryonic mesodermal cells to a hematopoietic fate in a number of systems. In the human AGM, we find that BMP-4 is expressed at high levels, and with striking polarity, in a region of densely packed cells underlying intra-aortic hematopoietic clusters. In contrast, TGF-1 is expressed predominantly by hematopoietic cells within the clusters. These findings implicate both BMP-4 and TGF-1 in the initiation and regulation of hematopoiesis in the human AGM. Furthermore, the distribution of BMP-4 expression is highly suggestive of a direct role in the specification of human hematopoietic cells from embryonic mesoderm in vivo. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. C. Goldman, A. S. Bailey, D. L. Pfaffle, A. Al Masri, J. L. Christian, and W. H. Fleming BMP4 regulates the hematopoietic stem cell niche Blood, November 12, 2009; 114(20): 4393 - 4401. [Abstract] [Full Text] [PDF] M. Peeters, K. Ottersbach, K. Bollerot, C. Orelio, M. de Bruijn, M. Wijgerde, and E. Dzierzak Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development Development, August 1, 2009; 136(15): 2613 - 2621. [Abstract] [Full Text] [PDF] C. Durand, C. Robin, K. Bollerot, M. H. Baron, K. Ottersbach, and E. Dzierzak Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells PNAS, December 26, 2007; 104(52): 20838 - 20843. [Abstract] [Full Text] [PDF] J. E. Pimanda, I. J. Donaldson, M. F. T. R. de Bruijn, S. Kinston, K. Knezevic, L. Huckle, S. Piltz, J.-R. Landry, A. R. Green, D. Tannahill, et al. The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity PNAS, January 16, 2007; 104(3): 840 - 845. [Abstract] [Full Text] [PDF] L. E. Lenox, J. M. Perry, and R. F. Paulson BMP4 and Madh5 regulate the erythroid response to acute anemia Blood, April 1, 2005; 105(7): 2741 - 2748. [Abstract] [Full Text] [PDF] J. Y. Bertrand, S. Giroux, R. Golub, M. Klaine, A. Jalil, L. 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