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Related Collections Neoplasia Apoptosis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2000, Vol. 96, No. 5, pp. 1921-1925 NEOPLASIA Prognostic significance of survivin expression in diffuse large B-cell lymphomas Colette Adida, Corinne Haioun, Philippe Gaulard, Eric Lepage, Pierre Morel, Josette Briere, Hervé Dombret, Felix Reyes, Jacques Diebold, Christian Gisselbrecht, Gilles Salles, Dario C. Altieri, and Thierry J. Molina From the Department of Pathology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT; Service d'Hématologie, Département de Pathologie, and Unité d'Informatique Médicale, Hôpital Henri Mondor, AP-HP, Créteil, France; Service d'Hématologie, Centre Hospitalier du Dr Schaffner, Lens, France; Service d'Anatomie Pathologique, AP-HP, and Institut d'Hématologie, Hôpital Saint-Louis, Paris, France; Service d'Anatomie Pathologique, Hôtel-Dieu, AP-HP, Paris, France; and Service d'Hématologie, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France. Survivin is an inhibitor of apoptosis overexpressed in various human cancers but undetectable in normal differentiated tissues. A potential expression and prognostic significance of survivin was studied in 222 patients with diffuse large B-cell lymphomas (centroblastic, 96%; immunoblastic, 4%). All patients were enrolled between 1987 and 1993 (median follow-up, 7 years) in the LNH87 protocol of the Groupe d'Etudes des Lymphomes de l'Adulte (GELA) and treated either with the reference ACVBP arm (doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone)[AU3A] (n = 79) or other experimental anthracycline-containing regimens (n = 143). The characteristics of these patients were median age of 56 years; serum lactate dehydrogenase (LDH) greater than 1N, 60%; stage III-IV, 55%; performance status, according to the Eastern Cooperative Oncology Group (ECOG) scale, more than 1, 23%; extranodal sites more than 1, 29%; mass more than 10 cm, 44%; bone marrow involvement, 15%. Of the 222 patients studied, 134 (60%) revealed survivin expression in virtually all tumor cells by immunohistochemistry. The overall 5-year survival rate was significantly lower in patients with survivin expression than in those without (40% vs 54%, P = .02). Multivariate analysis incorporating prognostic factors from the International Prognostic Index (IPI) identified survivin expression as an independent predictive parameter on survival (P = .03, relative risk [RR] = 1.6) in addition to LDH (P = .02, RR = 1.6), stage (P = .03, RR = 1.7), and ECOG scale (P = .05, RR = 1.6). A second analysis incorporating IPI as a unique parameter demonstrated that survivin expression (P = .02, RR = 1.6) remained a prognostic factor for survival independently of IPI (P = .001, RR = 1.5). Survivin expression may be considered a new unfavorable prognostic factor of diffuse large B-cell lymphoma. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Giaccone, P. Zatloukal, J. Roubec, K. Floor, J. Musil, M. Kuta, R. J. van Klaveren, S. Chaudhary, A. Gunther, and S. 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[Abstract] [Full Text] [PDF] C. G. Ferreira, M. Epping, F. A. E. Kruyt, and G. Giaccone Apoptosis: Target of Cancer Therapy Clin. Cancer Res., July 1, 2002; 8(7): 2024 - 2034. [Abstract] [Full Text] [PDF] D. F. Dukers, C. J. L. M. Meijer, R. L. ten Berge, W. Vos, G. J. Ossenkoppele, and J. J. Oudejans High numbers of active caspase 3-positive Reed-Sternberg cells in pretreatment biopsy specimens of patients with Hodgkin disease predict favorable clinical outcome Blood, June 17, 2002; 100(1): 36 - 42. [Abstract] [Full Text] [PDF] A. Chakravarti, E. Noll, P. McL. Black, D. F. Finkelstein, D. M. Finkelstein, N. J. Dyson, and J. S. Loeffler Quantitatively Determined Survivin Expression Levels Are of Prognostic Value in Human Gliomas J. Clin. Oncol., February 15, 2002; 20(4): 1063 - 1068. [Abstract] [Full Text] [PDF] J. R. Kanwar, W.-P. Shen, R. K. Kanwar, R. W. Berg, and G. W. 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Levy Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma Blood, August 15, 2001; 98(4): 945 - 951. [Abstract] [Full Text] [PDF] M. H. Andersen, L. O. Pedersen, B. Capeller, E.-B. Brocker, J. C. Becker, and P. thor Straten Spontaneous Cytotoxic T-Cell Responses against Survivin-derived MHC Class I-restricted T-Cell Epitopes in Situ As Well As ex Vivo in Cancer Patients Cancer Res., August 1, 2001; 61(16): 5964 - 5968. [Abstract] [Full Text] [PDF] C. G. Ferreira, P. van der Valk, S. W. Span, I. Ludwig, E. F. Smit, F. A. E. Kruyt, H. M. Pinedo, H. van Tinteren, and G. Giaccone Expression of X-linked Inhibitor of Apoptosis as a Novel Prognostic Marker in Radically Resected Non-Small Cell Lung Cancer Patients Clin. Cancer Res., August 1, 2001; 7(8): 2468 - 2474. [Abstract] [Full Text] [PDF] L. Granziero, P. Ghia, P. Circosta, D. Gottardi, G. Strola, M. Geuna, L. Montagna, P. Piccoli, M. Chilosi, and F. 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