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Blood, 1 September 2000, Vol. 96, No. 5, pp. 1996-1998

BRIEF REPORT

A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans

Michael H. Kohn and Hans-Joachim Pelz

From the Department of Organismic Biology, Ecology, and Evolution (OBEE), University of California at Los Angeles, Los Angeles, CA; Federal Biological Research Center for Agriculture and Forestry, Institute for Nematology and Vertebrate Research, Münster, Germany.

The locus underlying hereditary resistance to the anticoagulant warfarin (symbol in the rat, Rw) was placed in relation to 8 positionally mapped gene-anchored microsatellite loci whose positions were known in the genome maps of the rat, mouse, and human. Rw segregated with the markers Myl2 (zero recombinants) and Itgam, Il4r, and Fgf2r (one recombinant each) during linkage analysis in a congenic warfarin- and bromadiolone-resistant laboratory strain of rats. Comparative ortholog mapping between rat, mouse, and human placed Rw onto mouse chromosome 7 at about 60 to 63 cM and onto one of the human chromosomes 10q25.3-26, 12q23-q24.3, and 16p13.1-p11.

© 2000 by The American Society of Hematology.
 

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