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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fortunel, N. O. Articles by Hatzfeld, J. A. Search for Related Content PubMed PubMed Citation Articles by Fortunel, N. O. Articles by Hatzfeld, J. A. Related Collections Hematopoiesis and Stem Cells Signal Transduction Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 September 2000, Vol. 96, No. 6, pp. 2022-2036 REVIEW ARTICLE Transforming growth factor-: pleiotropic role in the regulation of hematopoiesis Nicolas O. Fortunel, Antoinette Hatzfeld, and Jacques A. Hatzfeld From the Laboratoire de Biologie des Cellules Souches Somatiques Humaines, Centre National de la Recherche Scientifique, Villejuif, France. Hematopoiesis is a remarkable cell-renewal process that leads to the continuous generation of large numbers of multiple mature cell types, starting from a relatively small stem cell compartment. A highly complex but efficient regulatory network is necessary to tightly control this production and to maintain the hematopoietic tissue in homeostasis. During the last 3 decades, constantly growing numbers of molecules involved in this regulation have been identified. They include soluble cytokines and growth factors, cell-cell interaction molecules, and extracellular matrix components, which provide a multifunctional scaffolding specific for each tissue. The cloning of numerous growth factors and their mass production have led to their possible use for both fundamental research and clinical application. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. James, F. Mazurier, S. Dupont, R. Chaligne, I. Lamrissi-Garcia, M. Tulliez, E. Lippert, F.-X. Mahon, J.-M. Pasquet, G. Etienne, et al. The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneity Blood, September 15, 2008; 112(6): 2429 - 2438. [Abstract] [Full Text] [PDF] M. M. Hauri-Hohl, S. Zuklys, M. P. Keller, L. T. Jeker, T. Barthlott, A. M. Moon, J. Roes, and G. A. Hollander TGF-{beta} signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution Blood, August 1, 2008; 112(3): 626 - 634. [Abstract] [Full Text] [PDF] T. Yoshida, I. Hazan, J. 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