|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 September 2000, Vol. 96, No. 6, pp. 2304-2306
BRIEF REPORT
Lack of serologic association of human herpesvirus-8
(KSHV) in patients with monoclonal gammopathy of
undetermined significance with and without progression to
multiple myeloma
Dharam V. Ablashi,
Louise Chatlynne,
David Thomas,
Dimitra Bourboulia,
Matthew B. Rettig,
Robert A. Vescio,
Dimitri Viza,
Parkash Gill,
Robert A. Kyle,
James R. Berenson, and
James E. Whitman Jr
From Advanced Biotechnologies Inc, Columbia, MD;
Georgetown University School of Medicine, Washington, DC; Departments
of Oncology and Molecular Pathology, Windeyer Institute of Medical
Science, University College London, United Kingdom;
Division of Hematology and Oncology, Veterans Affairs, West Los Angeles
Medical Center and University of California/Los Angeles, Los Angeles,
CA; Laboratoire d'immunologie, Faculté de Medicine,
Saints Peres, Paris, France; Division of Hematology,
Department of Medicine, University of Southern California, Los Angeles,
CA; and Division of Hematology, Mayo Clinic, Rochester, MN.
Because human herpesvirus-8 (HHV-8) DNA has been found in multiple
myeloma (MM) patients by polymerase chain reaction, it was suggested
that HHV-8 may play a role in the transformation of monoclonal
gammopathy of undetermined significance (MGUS) to MM. Therefore, 362 MGUS sera with and without progression to MM were tested for IgG
antibody to HHV-8. Only 7.8% of the MGUS sera contained HHV-8 antibody
to lytic proteins, and IgG antibody to HHV-8 latent antigen was even
lower than lytic antibody (2.9%). No differences were observed in the
distribution of antibody to HHV-8 in sera from MGUS patients who
progressed to MM. The seroprevalences of HHV-8 in MGUS (7.8%),
MM (5.4%), and healthy donors (5.9%) were similar, thus arguing for
the lack of epidemiologic evidence of HHV-8 participation in the
pathogenesis of MM. MGUS patients were immune competent in response to
Epstein-Barr virus (EBV) infection because 97% contained antibody to
EBV virus capsid antigen.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. Zhan, B. Barlogie, V. Arzoumanian, Y. Huang, D. R. Williams, K. Hollmig, M. Pineda-Roman, G. Tricot, F. van Rhee, M. Zangari, et al.
Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis
Blood,
February 15, 2007;
109(4):
1692 - 1700.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Sarid, A. Klepfish, and A. Schattner
Virology, Pathogenetic Mechanisms, and Associated Diseases of Kaposi Sarcoma-Associated Herpesvirus (Human Herpesvirus 8)
Mayo Clin. Proc.,
September 1, 2002;
77(9):
941 - 949.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. V. Ablashi, L. G. Chatlynne, J. E. Whitman Jr., and E. Cesarman
Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases
Clin. Microbiol. Rev.,
July 1, 2002;
15(3):
439 - 464.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
