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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hume, D. A. Search for Related Content PubMed PubMed Citation Articles by Hume, D. A. Related Collections Perspectives Hematopoiesis and Stem Cells Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 October 2000, Vol. 96, No. 7, pp. 2323-2328 PERSPECTIVE Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression David A. Hume From the Departments of Biochemistry and Microbiology/Parasitology and the Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia. The phenotype of individual hematopoietic cells, like all other differentiated mammalian cells, is determined by selective transcription of a subset of the genes encoded within the genome. This overview summarizes the recent evidence that transcriptional regulation at the level of individual cells is best described in terms of the regulation of the probability of transcription rather than the rate. In this model, heterogeneous gene expression among populations of cells arises by chance, and the degree of heterogeneity is a function of the stability of the mRNA and protein products of individual genes. The probabilistic nature of transcriptional regulation provides one explanation for stochastic phenomena, such as stem cell lineage commitment, and monoallelic expression of inducible genes, such as lymphokines and cytokines. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Pahle Biochemical simulations: stochastic, approximate stochastic and hybrid approaches Brief Bioinform, January 16, 2009; (2009) bbn050v1. [Abstract] [Full Text] [PDF] D. A. Hume Macrophages as APC and the Dendritic Cell Myth J. Immunol., November 1, 2008; 181(9): 5829 - 5835. [Abstract] [Full Text] [PDF] K. Pandya, J. Cowhig, J. Brackhan, H. S. Kim, J. Hagaman, M. Rojas, C. W. Carter Jr, L. Mao, H. A. Rockman, N. Maeda, et al. Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo PNAS, September 2, 2008; 105(35): 13063 - 13068. 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