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Blood, 1 October 2000, Vol. 96, No. 7, pp. 2355-2357
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Nonmalignant disease associated with human herpesvirus 8 reactivation in patients who have undergone autologous
peripheral blood stem cell transplantation
Mario Luppi,
Patrizia Barozzi,
Thomas F. Schulz,
Raffaella Trovato,
Amedea Donelli,
Franco Narni,
Julie Sheldon,
Roberto Marasca, and
Giuseppe Torelli
From the Department of Medical Sciences, Section of
Hematology, University of Modena, Italy; the Department of
Medical Microbiology and Genitourinary Medicine, University of
Liverpool, Liverpool, United Kingdom.
Fever, cutaneous rash, and hepatitis for which an infectious cause
was suspecteddeveloped in an Italian patient with non-Hodgkin lymphoma after autologous peripheral blood stem cell (PBSC)
transplantation. Polymerase chain reaction (PCR) with degenerate
primers for the highly conserved DNA polymerase gene of herpesviruses
detected herpesvirus sequences 100% identical to human herpesvirus-8
(HHV-8) in serial cell-free serum samples, collected immediately before or concomitant with the occurrence of clinical symptoms; no other common infections were documented. The presence of the HHV-8 genome (clade C) was confirmed by PCR with HHV-8-specific primers for orf 26 and orf-K1. HHV-8 viremia was undetectable either before transplantation or when the patient was clinically asymptomatic. Semiquantitative PCR analysis showed variations of the viral load correlating with the clinical status. Anti-HHV-8 antibodies were detected before and after transplantation by an immunofluorescence assay for lytic antigens. Active HHV-8 infection may be
associated with nonmalignant illness after PBSC/bone marrow transplantation.
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