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Blood, 1 October 2000, Vol. 96, No. 7, pp. 2511-2519
IMMUNOBIOLOGY
Concept of lymphoid versus myeloid dendritic cell lineages
revisited: both CD8  and CD8+
dendritic cells are generated from CD4low
lymphoid-committed precursors
Pilar Martín,
Gloria Martínez del
Hoyo,
Fabienne Anjuère,
Sara Ruiz Ruiz,
Cristina Fernández Arias,
Alvaro Rodríguez Marín, and
Carlos Ardavín
From the Department of Cell Biology, Faculty of
Biology, Complutense University, Madrid, Spain.
Two dendritic cell (DC) subsets have been identified in the murine
system on the basis of their differential CD8 expression. CD8+ DCs and CD8 DCs are considered as
lymphoid- and myeloid-derived, respectively, because
CD8+ but not CD8 splenic DCs were
generated from lymphoid CD4low precursors, devoid of
myeloid reconstitution potential. Although CD8 DCs
were first described as negative for CD4, our results demonstrate that
approximately 70% of them are CD4+. Besides
CD4 CD8 and CD4+
CD8 DCs displayed a similar phenotype and T-cell
stimulatory potential in mixed lymphocyte reaction (MLR),
although among CD8 DCs, the CD4+ subset
appears to have a higher endocytic capacity. Finally, experiments of DC
reconstitution after irradiation in which, in contrast to previous
studies, donor-type DCs were analyzed without depleting
CD4+ cells, revealed that both CD8+ DCs and
CD8 DCs were generated after transfer of
CD4low precursors. These data suggest that both
CD8+ and CD8 DCs derive from a common
precursor and, hence, do not support the concept of the
CD8+ lymphoid-derived and CD8
myeloid-derived DC lineages. However, because this hypothesis has to be
confirmed at the clonal level, it remains possible that CD8 DCs arise from a myeloid precursor within the
CD4low precursor population or, alternatively, that both
CD8+ and CD8 DCs derive from an
independent nonlymphoid, nonmyeloid DC precursor. In conclusion,
although we favor the hypothesis that both CD8+ and
CD8 DCs derive from a lymphoid-committed precursor, a
precise study of the differentiation process of CD8+ and
CD8 DCs is required to define conclusively their origin.
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
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January 1, 2002;
82(1):
97 - 130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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P. J. O'Connell, W. Li, Z. Wang, S. M. Specht, A. J. Logar, and A. W. Thomson
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168(1):
143 - 154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Wu, A. D'Amico, H. Hochrein, M. O'Keeffe, K. Shortman, and K. Lucas
Development of thymic and splenic dendritic cell populations from different hemopoietic precursors
Blood,
December 1, 2001;
98(12):
3376 - 3382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
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G. Schlecht, C. Leclerc, and G. Dadaglio
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October 15, 2001;
167(8):
4215 - 4221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Izon, K. Rudd, W. DeMuth, W. S. Pear, C. Clendenin, R. C. Lindsley, and D. Allman
A Common Pathway for Dendritic Cell and Early B Cell Development
J. Immunol.,
August 1, 2001;
167(3):
1387 - 1392.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Henri, D. Vremec, A. Kamath, J. Waithman, S. Williams, C. Benoist, K. Burnham, S. Saeland, E. Handman, and K. Shortman
The Dendritic Cell Populations of Mouse Lymph Nodes
J. Immunol.,
July 15, 2001;
167(2):
741 - 748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Kirby, U. Yrlid, M. Svensson, and M. J. Wick
Differential Involvement of Dendritic Cell Subsets During Acute Salmonella Infection
J. Immunol.,
June 1, 2001;
166(11):
6802 - 6811.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Manz, D. Traver, T. Miyamoto, I. L. Weissman, and K. Akashi
Dendritic cell potentials of early lymphoid and myeloid progenitors
Blood,
June 1, 2001;
97(11):
3333 - 3341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Martinon-Ego, R. Berthier, F. Cretin, V. Collin, A.-M. Laharie, and P. N. Marche
Murine Dendritic Cells Derived from Myeloid Progenitors of the Thymus Are Unable to Produce Bioactive IL-12p70
J. Immunol.,
April 15, 2001;
166(8):
5008 - 5017.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
