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Blood, 15 October 2000, Vol. 96, No. 8, pp. 2907-2909
BRIEF REPORT
Nonimmunoglobulin (non-Ig)/BCL6
gene fusion in diffuse large B-cell lymphoma results in worse prognosis
than Ig/BCL6
Takashi Akasaka,
Chiyoko Ueda,
Masayuki Kurata,
Hiroshi Akasaka,
Hirohiko Yamabe,
Takashi Uchiyama, and
Hitoshi Ohno
From the First Division, Department of Internal
Medicine and Laboratory of Anatomical Pathology, Faculty of Medicine,
Kyoto University, Kyoto, Japan.
Chromosomal translocation involving the BCL6 gene
affects not only immunoglobulin (Ig) genes but also a
number of non-Ig genes as partners. The molecular
anatomy of the BCL6 gene rearrangements in 39 cases with
diffuse large B-cell lymphoma (DLBCL) by long-distance polymerase chain
reaction-based assays was determined. The results showed that Ig
genes were affected in 21 cases; non-Ig genes, 15 cases; a deletion of more than a 1-kb segment, 2 cases; and a point
mutation, 1 case. Comparative studies between the 21 cases with
Ig gene partners and the 17 cases with non-Ig
gene partners, including 2 cases with the deletion, showed that
the overall survival of the latter group of patients was significantly
inferior to that of the former (P = .0440), and the
estimated 2-year overall survival rates were 58.3% vs 17.6%
(P = .005). Non-Ig/BCL6 fusion is
a poor prognostic indicator of DLBCL, and DLBCL with BCL6
translocation could be subclassified according to the individual
partner locus and/or gene.
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