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 Previous Article | Table of Contents
Blood, 15 October 2000, Vol. 96, No. 8, pp. 2910-2912
BRIEF REPORT
Bcl-2 rearrangement in patients with chronic hepatitis C
associated with essential mixed cryoglobulinemia type II
Yona Kitay-Cohen,
Aliza Amiel,
Nir Hilzenrat,
Dan Buskila,
Yaffa Ashur,
Moshe Fejgin,
Elena Gaber,
Rifaat Safadi,
Ran Tur-kaspa, and
Michael Lishner
From the Departments of Medicine and Genetics, Meir
Hospital, Kfar-Saba and Sackler Faculty of Medicine, Tel Aviv
University, Tel Aviv; Department of Medicine, Soroka Hospital and
Ben-Gurion University, Beersheba; Liver Unit, Hadassah University
Hospital, Jerusalem; and Liver Institute, Rabin Medical Center, Petah
Tiqwa, Israel.
Hepatitis C virus (HCV) infection is found in 80% to 90% of
patients with essential mixed cryoglobulinemia (EMC) type II, which is
associated with monoclonal IgMk produced by monoclonal B cells. It was
investigated whether bcl-2 rearrangement is associated with the clonal
B-cell proliferation of EMC induced by hepatitis C. The study groups
were composed of 15 patients with HCV and EMC, 12 patients with HCV
without EMC, and 7 patients with chronic liver disease (CLD) unrelated
to HCV. Fluorescence in situ hybridization with probes was applied to
JH and to bcl-2 to study whether JH/bcl-2 translocation was present in
these patients. Thirteen of 15 (86%) of patients with HCV-related EMC
had the JH/bcl-2 translocation, a significantly higher rate than in HCV
patients without EMC (16%; P < .001). Bcl-2
rearrangement was not detected in the patients with CLD not related to
HCV. The JH/bcl2 translocation may constitute a pathogenetic link for
the development of NHL in patients with HCV infection.
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