SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhao, Y. Articles by Anderson, W. F. Search for Related Content PubMed PubMed Citation Articles by Zhao, Y. Articles by Anderson, W. F. Related Collections Hematopoiesis and Stem Cells Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 November 2000, Vol. 96, No. 9, pp. 3016-3022 HEMATOPOIESIS Murine hematopoietic stem cell characterization and its regulation in BM transplantation Yi Zhao, Yuanguang Lin, Yuxia Zhan, Gengjie Yang, Jeffrey Louie, David E. Harrison, and W. French Anderson From Gene Therapy Laboratories, Norris Cancer Center, University of Southern California (USC) Keck School of Medicine, Los Angeles, CA; the Division of Hematology, Department of Medicine, USC Keck School of Medicine, Los Angeles, CA; USC Flow Cytometry Laboratory, Department of Pathology, USC Keck School of Medicine, Los Angeles, CA; and Jackson Laboratory, Bar Harbor, ME. Using 5-color fluorescence-activated cell sorting, we isolated a subset of murine pluripotent hematopoietic stem cells (PHSC) with the phenotype Lin Sca+ kit+ CD38+ CD34 that appears to fulfill the criteria for most primitive PHSC. In the presence of whole bone marrow (BM) competitor cells, these cells produced reconstitution in lethally irradiated primary, secondary, and tertiary murine transplant recipients over the long term. However, these cells alone could not produce reconstitution in lethally irradiated recipients. Rapid proliferation of these cells after BM transplantation required the assistance of another BM cell subset, which has the phenotype Lin Sca+ kit+ CD38 CD34+. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. J. Lannutti, A. Epp, J. Roy, J. Chen, and N. C. Josephson Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis Blood, February 19, 2009; 113(8): 1778 - 1785. [Abstract] [Full Text] [PDF] J. Chagraoui, S. L. Niessen, J. Lessard, S. Girard, P. Coulombe, M. Sauvageau, S. Meloche, and G. Sauvageau E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells Genes & Dev., August 1, 2006; 20(15): 2110 - 2120. [Abstract] [Full Text] [PDF] A. L. Smith, F. M. Ellison, J. P. McCoy Jr., and J. Chen c-Kit Expression and Stem Cell Factor-Induced Hematopoietic Cell Proliferation Are Up-Regulated in Aged B6D2F1 Mice J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2005; 60(4): 448 - 456. [Abstract] [Full Text] [PDF] L. Yang, D. Bryder, J. Adolfsson, J. Nygren, R. Mansson, M. Sigvardsson, and S. E. W. Jacobsen Identification of Lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients Blood, April 1, 2005; 105(7): 2717 - 2723. [Abstract] [Full Text] [PDF] J. F. Zhong, Y. Zhao, S. Sutton, A. Su, Y. Zhan, L. Zhu, C. Yan, T. Gallaher, P. B. Johnston, W. F. Anderson, et al. Gene expression profile of murine long-term reconstituting vs. short-term reconstituting hematopoietic stem cells PNAS, February 15, 2005; 102(7): 2448 - 2453. [Abstract] [Full Text] [PDF] J. Chen, K. Lipovsky, F. M. Ellison, R. T. Calado, and N. S. Young Bystander destruction of hematopoietic progenitor and stem cells in a mouse model of infusion-induced bone marrow failure Blood, September 15, 2004; 104(6): 1671 - 1678. [Abstract] [Full Text] [PDF] D. Bryder, Y. Sasaki, O. J. Borge, and S.-E. W. Jacobsen Deceptive Multilineage Reconstitution Analysis of Mice Transplanted with Hemopoietic Stem Cells, and Implications for Assessment of Stem Cell Numbers and Lineage Potentials J. Immunol., February 1, 2004; 172(3): 1548 - 1552. [Abstract] [Full Text] [PDF] L. S. Kean, E. A. Manci, J. Perry, C. Balkan, S. Coley, D. Holtzclaw, A. B. Adams, C. P. Larsen, L. L. Hsu, and D. R. Archer Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease Blood, December 15, 2003; 102(13): 4582 - 4593. [Abstract] [Full Text] [PDF] C. Y. Ito, C. Y. J. Li, A. Bernstein, J. E. Dick, and W. L. Stanford Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice Blood, January 15, 2003; 101(2): 517 - 523. [Abstract] [Full Text] [PDF] P. A. Plett, S. M. Frankovitz, and C. M. Orschell-Traycoff In vivo trafficking, cell cycle activity, and engraftment potential of phenotypically defined primitive hematopoietic cells after transplantation into irradiated or nonirradiated recipients Blood, November 15, 2002; 100(10): 3545 - 3552. [Abstract] [Full Text] [PDF] J. F. Zhong, Y. Zhan, W. F. Anderson, and Y. Zhao Murine hematopoietic stem cell distribution and proliferation in ablated and nonablated bone marrow transplantation Blood, November 15, 2002; 100(10): 3521 - 3526. [Abstract] [Full Text] [PDF] P. Pinto do O, K. Richter, and L. Carlsson Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo Blood, May 13, 2002; 99(11): 3939 - 3946. [Abstract] [Full Text] [PDF] T. Graf Differentiation plasticity of hematopoietic cells Blood, May 1, 2002; 99(9): 3089 - 3101. [Full Text] [PDF]

	Copyright © 2000 by American Society of Hematology         Online ISSN: 1528-0020