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Blood, 1 November 2000, Vol. 96, No. 9, pp. 3023-3028
HEMATOPOIESIS
Imprinting of insulin-like growth factor 2 is modulated during
hematopoiesis
Ian M. Morison,
Michael R. Eccles, and
Anthony
E. Reeve
From the Cancer Genetics Laboratory, Department of
Biochemistry, University of Otago, Dunedin, New Zealand.
The transcription of insulin-like growth factor 2 (IGF-2) is affected by genomic imprinting, a multistep
process through which the parental origin of a gene influences its
transcription. The maternal copy of IGF-2 is silenced in
most human tissues, but in the choroid plexus and the adult liver both
alleles of IGF-2 are expressed. This study shows that
though in peripheral blood mononuclear cells IGF-2
shows paternal allele-specific expression, in total bone marrow both
alleles are transcribed. This modulation of imprinting is not
attributable to use of the P1 promoter, because transcription from the
P3 promoter occurred from both alleles. These results suggest
that transcriptional recognition of the IGF-2 imprint can
be modulated during hematopoiesis and may facilitate the development of
in vitro model systems to study the transcriptional recognition of a
genomic imprint.
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