|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 November 2000, Vol. 96, No. 9, pp. 3126-3132
IMMUNOBIOLOGY
UTY gene codes for an HLA-B60-restricted human
male-specific minor histocompatibility antigen involved in stem cell
graft rejection: characterization of the critical polymorphic amino
acid residues for T-cell recognition
Mario H. J. Vogt,
Els Goulmy,
Freke M. Kloosterboer,
Els Blokland,
Roel A. de
Paus,
Roel Willemze, and
J. H. Frederik Falkenburg
From the Departments of Hematology and Immunohematology
and Bloodbank, Leiden University Medical Center, Leiden, The
Netherlands.
Rejection of a graft after human leukocyte antigen
(HLA)-identical stem cell transplantation (SCT) can be caused by
recipient's immunocompetent T lymphocytes recognizing minor
histocompatibility antigens on donor stem cells. During rejection of a
male stem cell graft by a female recipient, 2 male (H-Y)-specific
cytotoxic T lymphocyte (CTL) clones were isolated from peripheral
blood. One CTL clone recognized an HLA-A2-restricted H-Y antigen,
encoded by the SMCY gene. Another CTL clone recognized an
HLA-B60-restricted H-Y antigen. In this study UTY was
identified as the gene coding for the HLA-B60-restricted H-Y antigen.
The UTY-derived H-Y antigen was characterized as a 10-amino
acid residue peptide, RESEEESVSL. Although the epitope differed by
3 amino acids from its X-homologue, UTX, only 2 polymorphisms were
essential for recognition by the CTL clone HLA-B60 HY. These
results illustrate that CTLs against several H-Y antigens derived from
different proteins can contribute simultaneously to graft rejection
after HLA-identical, sex-mismatched SCT. Moreover, RESEEESVSL-specific
T cells could be isolated from a female HLA-B60+ patient with
myelodysplastic syndrome who has been treated with multiple blood
transfusions, but not from control healthy HLA-B60+ female
donors. This may indicate that RESEEESVSL-reactive T cells are more
common in sensitized patients.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. V. Rosinski, N. Fujii, J. K. Mito, K. K. W. Koo, S. M. Xuereb, O. Sala-Torra, J. S. Gibbs, J. P. Radich, Y. Akatsuka, B. J. Van den Eynde, et al.
DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells
Blood,
May 1, 2008;
111(9):
4817 - 4826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Rezvani, A. S. M. Yong, B. N. Savani, S. Mielke, K. Keyvanfar, E. Gostick, D. A. Price, D. C. Douek, and A. J. Barrett
Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia
Blood,
September 15, 2007;
110(6):
1924 - 1932.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Zimring, G. A. Hair, S. S. Deshpande, and J. T. Horan
Immunization to minor histocompatibility antigens on transfused RBCs through crosspriming into recipient MHC class I pathways
Blood,
January 1, 2006;
107(1):
187 - 189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Millrain, D. Scott, C. Addey, H. Dewchand, P. Ellis, I. Ehrmann, M. Mitchell, P. Burgoyne, E. Simpson, and J. Dyson
Identification of the Immunodominant HY H2-Dk Epitope and Evaluation of the Role of Direct and Indirect Antigen Presentation in HY Responses
J. Immunol.,
December 1, 2005;
175(11):
7209 - 7217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Provost and Y. Tremblay
Genes Involved in the Adrenal Pathway of Glucocorticoid Synthesis Are Transiently Expressed in the Developing Lung
Endocrinology,
May 1, 2005;
146(5):
2239 - 2245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Miklos, H. T. Kim, K. H. Miller, L. Guo, E. Zorn, S. J. Lee, E. P. Hochberg, C. J. Wu, E. P. Alyea, C. Cutler, et al.
Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission
Blood,
April 1, 2005;
105(7):
2973 - 2978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ivanov, T. Aarts, S. Hol, A. Doornenbal, A. Hagenbeek, E. Petersen, and S. Ebeling
Identification of a 40S Ribosomal Protein S4-Derived H-Y Epitope Able to Elicit a Lymphoblast-Specific Cytotoxic T Lymphocyte Response
Clin. Cancer Res.,
March 1, 2005;
11(5):
1694 - 1703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Higuchi, T. Maruyama, A. Jaramillo, and T. Mohanakumar
Induction of Obliterative Airway Disease in Murine Tracheal Allografts by CD8+ CTLs Recognizing a Single Minor Histocompatibility Antigen
J. Immunol.,
February 15, 2005;
174(4):
1871 - 1878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Torikai, Y. Akatsuka, M. Miyazaki, E. H. Warren III, T. Oba, K. Tsujimura, K. Motoyoshi, Y. Morishima, Y. Kodera, K. Kuzushima, et al.
A Novel HLA-A*3303-Restricted Minor Histocompatibility Antigen Encoded by an Unconventional Open Reading Frame of Human TMSB4Y Gene
J. Immunol.,
December 1, 2004;
173(11):
7046 - 7054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-G. Chai, E. James, H. Dewchand, E. Simpson, and D. Scott
Transplantation tolerance induced by intranasal administration of HY peptides
Blood,
May 15, 2004;
103(10):
3951 - 3959.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Zorn, D. B. Miklos, B. H. Floyd, A. Mattes-Ritz, L. Guo, R. J. Soiffer, J. H. Antin, and J. Ritz
Minor Histocompatibility Antigen DBY Elicits a Coordinated B and T Cell Response after Allogeneic Stem Cell Transplantation
J. Exp. Med.,
April 19, 2004;
199(8):
1133 - 1142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Miklos, H. T. Kim, E. Zorn, E. P. Hochberg, L. Guo, A. Mattes-Ritz, S. Viatte, R. J. Soiffer, J. H. Antin, and J. Ritz
Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors
Blood,
January 1, 2004;
103(1):
353 - 359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Hirano, M. O. Butler, M. S. von Bergwelt-Baildon, B. Maecker, J. L. Schultze, K. C. O'Connor, P. H. Schur, S. Kojima, E. C. Guinan, and L. M. Nadler
Autoantibodies frequently detected in patients with aplastic anemia
Blood,
December 15, 2003;
102(13):
4567 - 4575.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Akatsuka, T. Nishida, E. Kondo, M. Miyazaki, H. Taji, H. Iida, K. Tsujimura, M. Yazaki, T. Naoe, Y. Morishima, et al.
Identification of a Polymorphic Gene, BCL2A1, Encoding Two Novel Hematopoietic Lineage-specific Minor Histocompatibility Antigens
J. Exp. Med.,
June 2, 2003;
197(11):
1489 - 1500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Murata, E. H. Warren, and S. R. Riddell
A Human Minor Histocompatibility Antigen Resulting from Differential Expression due to a Gene Deletion
J. Exp. Med.,
May 19, 2003;
197(10):
1279 - 1289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. A. E. Marijt, M. H. M. Heemskerk, F. M. Kloosterboer, E. Goulmy, M. G. D. Kester, M. A. W. G. van der Hoorn, S. A. P. van Luxemburg-Heys, M. Hoogeboom, T. Mutis, J. W. Drijfhout, et al.
Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia
PNAS,
March 4, 2003;
100(5):
2742 - 2747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. J. Barrett, K. Rezvani, S. Solomon, A. M. Dickinson, X. N. Wang, G. Stark, H. Cullup, M. Jarvis, P. G. Middleton, and N. Chao
New Developments in Allotransplant Immunology
Hematology,
January 1, 2003;
2003(1):
350 - 371.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Contu, L. Morelli, P. Zavattari, R. Lampis, E. Angius, P. Frongia, D. Murru, M. Maioli, P. Francalacci, J. A. Todd, et al.
Sex-Related Bias and Exclusion Mapping of the Nonrecombinant Portion of Chromosome Y in Human Type 1 Diabetes in the Isolated Founder Population of Sardinia
Diabetes,
December 1, 2002;
51(12):
3573 - 3576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. James, D. Scott, J.-G. Chai, M. Millrain, P. Chandler, and E. Simpson
HY peptides modulate transplantation responses to skin allografts
Int. Immunol.,
November 1, 2002;
14(11):
1333 - 1342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-F. Yang, C. J. Wu, L. Chen, E. P. Alyea, C. Canning, P. Kantoff, R. J. Soiffer, G. Dranoff, and J. Ritz
CML28 Is a Broadly Immunogenic Antigen, Which Is Overexpressed in Tumor Cells
Cancer Res.,
October 1, 2002;
62(19):
5517 - 5522.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Guimond, A. Balassy, M. Barrette, S. Brochu, C. Perreault, and D. C. Roy
P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells
Blood,
June 28, 2002;
100(2):
375 - 382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. J. Vogt, J. W. van den Muijsenberg, E. Goulmy, E. Spierings, P. Kluck, M. G. Kester, R. A. van Soest, J. W. Drijfhout, R. Willemze, and J. H. F. Falkenburg
The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease
Blood,
April 15, 2002;
99(8):
3027 - 3032.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. T. Ho and R. J. Soiffer
The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation
Blood,
December 1, 2001;
98(12):
3192 - 3204.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Nisini, G. Romagnoli, M. J. Gomez, R. La Valle, A. Torosantucci, S. Mariotti, R. Teloni, and A. Cassone
Antigenic Properties and Processing Requirements of 65-Kilodalton Mannoprotein, a Major Antigen Target of Anti-Candida Human T-Cell Response, as Disclosed by Specific Human T-Cell Clones
Infect. Immun.,
June 1, 2001;
69(6):
3728 - 3736.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. F. Storb, R. Champlin, S. R. Riddell, M. Murata, S. Bryant, and E. H. Warren
Non-Myeloablative Transplants for Malignant Disease
Hematology,
January 1, 2001;
2001(1):
375 - 391.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
