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Blood, 15 May 2001, Vol. 97, No. 10, pp. 3146-3151
IMMUNOBIOLOGY
Human natural killer cells: a unique innate immunoregulatory
role for the CD56bright subset
Megan A. Cooper,
Todd A. Fehniger,
Sarah C. Turner,
Kenneth S. Chen,
Bobak A. Ghaheri,
Tariq Ghayur,
William E. Carson, and
Michael A. Caligiuri
From the Department of Internal Medicine, Division of
Hematology/Oncology; the Department of Molecular Virology, Immunology
and Medical Genetics, Division of Human Cancer Genetics; the Department
of Surgery; and the Comprehensive Cancer Center, The Ohio State
University, Columbus, OH; and BASF Bioresearch Corporation, Worcester,
MA.
During the innate immune response to infection,
monocyte-derived cytokines (monokines), stimulate natural killer (NK)
cells to produce immunoregulatory cytokines that are important to the host's early defense. Human NK cell subsets can be distinguished by
CD56 surface density expression (ie, CD56bright and
CD56dim). In this report, it is shown that
CD56bright NK cells produce significantly greater levels of
interferon- , tumor necrosis factor- , granulocyte
macrophage-colony-stimulating factor, IL-10, and IL-13 protein in
response to monokine stimulation than do CD56dim NK cells,
which produce negligible amounts of these cytokines. Further,
qualitative differences in CD56bright NK-derived cytokines
are shown to be dependent on the specific monokines present. For
example, the monokine IL-15 appears to be required for type 2 cytokine
production by CD56bright NK cells. It is proposed that
human CD56bright NK cells have a unique functional role in
the innate immune response as the primary source of NK cell-derived
immunoregulatory cytokines, regulated in part by differential
monokine production.
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|
|
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[Full Text]
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|
|
|
|
|
|
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|
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elm037v1.
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|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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110(9):
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
|
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21(10):
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|
|
|
|
|
|
|
F. B. Thoren, A. I. Romero, S. Hermodsson, and K. Hellstrand
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|
|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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178(8):
4947 - 4955.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Noessner and J. S. Schleypen
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March 1, 2007;
13(5):
1621 - 1621.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Giustiniani, A. Marie-Cardine, and A. Bensussan
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178(3):
1293 - 1300.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Y. Pappworth, E. C. Wang, and M. Rowe
The Switch from Latent to Productive Infection in Epstein-Barr Virus-Infected B Cells Is Associated with Sensitization to NK Cell Killing
J. Virol.,
January 15, 2007;
81(2):
474 - 482.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-S. He, T. H. Holmes, C. Zhang, K. Mahmood, G. W. Kemble, D. B. Lewis, C. L. Dekker, H. B. Greenberg, and A. M. Arvin
Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines
J. Virol.,
December 1, 2006;
80(23):
11756 - 11766.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Grzywacz, N. Kataria, M. Sikora, R. A. Oostendorp, E. A. Dzierzak, B. R. Blazar, J. S. Miller, and M. R. Verneris
Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells
Blood,
December 1, 2006;
108(12):
3824 - 3833.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Fulci, L. Breymann, D. Gianni, K. Kurozomi, S. S. Rhee, J. Yu, B. Kaur, D. N. Louis, R. Weissleder, M. A. Caligiuri, et al.
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
PNAS,
August 22, 2006;
103(34):
12873 - 12878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. S. Gorski, E. L. Waller, J. Bjornton-Severson, J. A. Hanten, C. L. Riter, W. C. Kieper, K. B. Gorden, J. S. Miller, J. P. Vasilakos, M. A. Tomai, et al.
Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists
Int. Immunol.,
July 1, 2006;
18(7):
1115 - 1126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Monk, G. Phillips, R. Waite, J. Kuhn, L. J. Schaaf, G. A. Otterson, D. Guttridge, C. Rhoades, M. Shah, T. Criswell, et al.
Assessment of Tumor Necrosis Factor Alpha Blockade As an Intervention to Improve Tolerability of Dose-Intensive Chemotherapy in Cancer Patients
J. Clin. Oncol.,
April 20, 2006;
24(12):
1852 - 1859.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Freud, A. Yokohama, B. Becknell, M. T. Lee, H. C. Mao, A. K. Ferketich, and M. A. Caligiuri
Evidence for discrete stages of human natural killer cell differentiation in vivo
J. Exp. Med.,
April 17, 2006;
203(4):
1033 - 1043.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bielekova, M. Catalfamo, S. Reichert-Scrivner, A. Packer, M. Cerna, T. A. Waldmann, H. McFarland, P. A. Henkart, and R. Martin
Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2R{alpha}-targeted therapy (daclizumab) in multiple sclerosis
PNAS,
April 11, 2006;
103(15):
5941 - 5946.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Mavoungou
Interactions between natural killer cells, cortisol and prolactin in malaria during pregnancy.
Clin. Med. Res.,
March 1, 2006;
4(1):
33 - 41.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Zhang, X. Zheng, B. Li, H. Wei, and Z. Tian
Human NK Cells Positively Regulate {gamma}{delta} T Cells in Response to Mycobacterium tuberculosis
J. Immunol.,
February 15, 2006;
176(4):
2610 - 2616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Schleypen, N. Baur, R. Kammerer, P. J. Nelson, K. Rohrmann, E. F. Grone, M. Hohenfellner, A. Haferkamp, H. Pohla, D. J. Schendel, et al.
Cytotoxic Markers and Frequency Predict Functional Capacity of Natural Killer Cells Infiltrating Renal Cell Carcinoma
Clin. Cancer Res.,
February 1, 2006;
12(3):
718 - 725.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cebo, S. Da Rocha, S. Wittnebel, A. G. Turhan, J. Abdelali, S. Caillat-Zucman, J. H. Bourhis, S. Chouaib, and A. Caignard
The Decreased Susceptibility of Bcr/Abl Targets to NK Cell-Mediated Lysis in Response to Imatinib Mesylate Involves Modulation of NKG2D Ligands, GM1 Expression, and Synapse Formation
J. Immunol.,
January 15, 2006;
176(2):
864 - 872.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Perez, L. G. Mahaira, P. A. Sotiropoulou, A. D. Gritzapis, E. G. Iliopoulou, D. K. Niarchos, N. T. Cacoullos, Y. G. Kavalakis, A. I. Antsaklis, N. N. Sotiriadou, et al.
Effect of IL-21 on NK cells derived from different umbilical cord blood populations
Int. Immunol.,
January 1, 2006;
18(1):
49 - 58.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Sotiropoulou, S. A. Perez, A. D. Gritzapis, C. N. Baxevanis, and M. Papamichail
Interactions Between Human Mesenchymal Stem Cells and Natural Killer Cells
Stem Cells,
January 1, 2006;
24(1):
74 - 85.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Cooley, V. McCullar, R. Wangen, T. L. Bergemann, S. Spellman, D. J. Weisdorf, and J. S. Miller
KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation
Blood,
December 15, 2005;
106(13):
4370 - 4376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Korbel, K. C. Newman, C. R. Almeida, D. M. Davis, and E. M. Riley
Heterogeneous Human NK Cell Responses to Plasmodium falciparum-Infected Erythrocytes
J. Immunol.,
December 1, 2005;
175(11):
7466 - 7473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Schierloh, N. Yokobori, M. Aleman, R. M. Musella, M. Beigier-Bompadre, M. A. Saab, L. Alves, E. Abbate, S. S. de la Barrera, and M. C. Sasiain
Increased Susceptibility to Apoptosis of CD56dimCD16+ NK Cells Induces the Enrichment of IFN-{gamma}-Producing CD56bright Cells in Tuberculous Pleurisy
J. Immunol.,
November 15, 2005;
175(10):
6852 - 6860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Alter, N. Teigen, B. T. Davis, M. M. Addo, T. J. Suscovich, M. T. Waring, H. Streeck, M. N. Johnston, K. D. Staller, M. T. Zaman, et al.
Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection
Blood,
November 15, 2005;
106(10):
3366 - 3369.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
