SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Afshar-Kharghan, V. Articles by López, J. A. Search for Related Content PubMed PubMed Citation Articles by Afshar-Kharghan, V. Articles by López, J. A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Cell Adhesion and Motility Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2001, Vol. 97, No. 10, pp. 3306-3307 BRIEF REPORT Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region Vahid Afshar-Kharghan, Reyhan Diz-Küçükkaya, Erwin H. Ludwig, Ali J. Marian, and José A. López From the Departments of Medicine and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, and the Gladstone Institute of Cardiovascular Disease, San Francisco, CA. Platelet GP Ib and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1) are membrane mucins with a number of structural and functional similarities. It was investigated whether, like GP Ib, PSGL-1 is affected by a variable number of tandem repeat polymorphism in its mucin-like region. By polymerase chain reaction amplification of the genomic region encoding the PSGL-1 repeats, 3 allelic variants were identified in the human population. The 3 allelesA, B, and Cfrom largest to smallest, contained 16, 15, and 14 decameric repeats, respectively, with the B variant lacking repeat 2 and the C variant retaining repeat 2 but lacking repeats 9 and 10. Allele frequencies were highest for the A variant and lowest for the C variant in the 2 populations studied (frequencies of 0.81, 0.17, and 0.02 in white persons and 0.65, 0.35, and 0.00 in Japanese). Thus, PSGL-1 is highly polymorphic and contains a structural polymorphism that potentially indicates functional variation in the human population. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Zarbock, H. Muller, Y. Kuwano, and K. Ley PSGL-1-dependent myeloid leukocyte activation J. Leukoc. Biol., November 1, 2009; 86(5): 1119 - 1124. [Abstract] [Full Text] [PDF] C. Tauxe, X. Xie, M. Joffraud, M. Martinez, M. Schapira, and O. Spertini P-selectin Glycoprotein Ligand-1 Decameric Repeats Regulate Selectin-dependent Rolling under Flow Conditions J. Biol. Chem., October 17, 2008; 283(42): 28536 - 28545. [Abstract] [Full Text] [PDF] R. Diz-Kucukkaya, M. Inanc, V. Afshar-Kharghan, Q E. Zhang, J. A Lopez, and Y. Pekcelen P-selectin glycoprotein ligand-1 VNTR polymorphisms and risk of thrombosis in the antiphospholipid syndrome Ann Rheum Dis, October 1, 2007; 66(10): 1378 - 1380. [Abstract] [Full Text] [PDF] E. Green, G. Elvidge, N. Jacobsen, B. Glaser, I. Jones, M. C. O'Donovan, G. Kirov, M. J. Owen, and N. Craddock Localization of Bipolar Susceptibility Locus by Molecular Genetic Analysis of the Chromosome 12q23-q24 Region in Two Pedigrees With Bipolar Disorder and Darier's Disease Am J Psychiatry, January 1, 2005; 162(1): 35 - 42. [Abstract] [Full Text] [PDF] A. D. Blann, S. K. Nadar, and G. Y.H. Lip The adhesion molecule P-selectin and cardiovascular disease Eur. Heart J., December 2, 2003; 24(24): 2166 - 2179. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020