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Related Collections Hematopoiesis and Stem Cells Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 June 2001, Vol. 97, No. 11, pp. 3354-3360 CHEMOKINES Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells Koichi Hattori, Beate Heissig, Kei Tashiro, Tasuku Honjo, Masatoshi Tateno, Jae-Hung Shieh, Neil R. Hackett, Mannix S. Quitoriano, Ronald G. Crystal, Shahin Rafii, and Malcolm A. S. Moore From the James Ewing Laboratory of Developmental Hematopoiesis, Sloan-Kettering Institute for Cancer Research; Division of Hematology-Oncology, Weill Medical College of Cornell University; and Division of Pulmonary and Critical Care Medicine, The New York Hospital-Cornell Medical Center, New York, NY; the Center for Molecular Biology and Genetics, and Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan; and the Department of Pathology, Sapporo City General Hospital, Japan. The chemokine, stromal cell-derived factor-1 (SDF1), is produced in the bone marrow and has been shown to modulate the homing of stem cells to this site by mediating chemokinesis and chemotaxis. Therefore, it was hypothesized that elevation of SDF1 level in the peripheral circulation would result in mobilization of primitive hematopoietic stem and progenitor cells. SDF1 plasma level was increased by intravenous injection of an adenoviral vector expressing SDF1 (AdSDF1) into severe combined immunodeficient mice. This resulted in a 10-fold increase in leukocyte count, a 3-fold increase in platelets, and mobilization of progenitors, including colony-forming units-granulocyte-macrophage to the peripheral circulation. In addition, AdSDF1 induced mobilization of cells with stem cell potential, including colony-forming units in spleen and long-term reconstituting cells. These data demonstrate that overexpression of SDF1 in the peripheral circulation results in the mobilization of hematopoietic cells with repopulating capacity, progenitor cells, and precursor cells. These studies lay the foundation for using SDF1 to induce mobilization of hematopoietic stem and progenitor cells in in vivo studies. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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