|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 June 2001, Vol. 97, No. 11, pp. 3491-3497
IMMUNOBIOLOGY
Expression of interferon consensus sequence binding protein
induces potent immunity against BCR/ABL-induced
leukemia
Ming Deng and
George Q. Daley
From the Whitehead Institute, Cambridge, Massachusetts,
and Division of Hematology/Oncology, Massachusetts General Hospital,
Harvard Medical School, Boston, MA.
Mice deficient in the interferon consensus sequence binding protein
(ICSBP) develop a disease resembling chronic myeloid leukemia (CML),
which in humans is caused by the BCR/ABL oncoprotein. Interferon- (IFN-) induces ICSBP expression and is an effective therapy for CML.
This study examined whether enforced expression of ICSBP might
antagonize BCR/ABL-induced leukemia; results demonstrated that
ICSBP-modified cells generated a protective CD8+ cytotoxic
T-cell response against BCR/ABL-transformed BaF3 cells in a murine
leukemia model. ICSBP expression represents a novel means of
stimulating a host immune response to BCR/ABL+ leukemia
cells and a potential strategy for immunotherapy of CML.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
N. Dror, N. Rave-Harel, A. Burchert, A. Azriel, T. Tamura, P. Tailor, A. Neubauer, K. Ozato, and B.-Z. Levi
Interferon Regulatory Factor-8 Is Indispensable for the Expression of Promyelocytic Leukemia and the Formation of Nuclear Bodies in Myeloid Cells
J. Biol. Chem.,
February 23, 2007;
282(8):
5633 - 5640.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Turcotte, S. Gauthier, A. Tuite, A. Mullick, D. Malo, and P. Gros
A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice
J. Exp. Med.,
March 21, 2005;
201(6):
881 - 890.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Baccarani, G. Martinelli, G. Rosti, E. Trabacchi, N. Testoni, S. Bassi, M. Amabile, S. Soverini, F. Castagnetti, D. Cilloni, et al.
Imatinib and pegylated human recombinant interferon-{alpha}2b in early chronic-phase chronic myeloid leukemia
Blood,
December 15, 2004;
104(13):
4245 - 4251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. P. Shah, C. Tran, F. Y. Lee, P. Chen, D. Norris, and C. L. Sawyers
Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor
Science,
July 16, 2004;
305(5682):
399 - 401.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Burchert, D. Cai, L. C. Hofbauer, M. K. R. Samuelsson, E. P. Slater, J. Duyster, M. Ritter, A. Hochhaus, R. Muller, M. Eilers, et al.
Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2
Blood,
May 1, 2004;
103(9):
3480 - 3489.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Tamura, H. J. Kong, C. Tunyaplin, H. Tsujimura, K. Calame, and K. Ozato
ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells
Blood,
December 15, 2003;
102(13):
4547 - 4554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tsujimura, T. Nagamura-Inoue, T. Tamura, and K. Ozato
IFN Consensus Sequence Binding Protein/IFN Regulatory Factor-8 Guides Bone Marrow Progenitor Cells Toward the Macrophage Lineage
J. Immunol.,
August 1, 2002;
169(3):
1261 - 1269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kallies, F. Rosenbauer, M. Scheller, K.-P. Knobeloch, and I. Horak
Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages
Blood,
May 1, 2002;
99(9):
3213 - 3219.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
