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Related Collections Immunobiology Brief Reports Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 June 2001, Vol. 97, No. 12, pp. 3992-3994 BRIEF REPORT Expression of macrophage inflammatory protein-3, stromal cell-derived factor-1, and B-cell-attracting chemokine-1 identifies the tonsil crypt as an attractive site for B cells Montserrat Casamayor-Pallejà, Paul Mondière, Ali Amara, Chantal Bella, Marie-Caroline Dieu-Nosjean, Christophe Caux, and Thierry Defrance From INSERM U404, Immunité et Vaccination, Lyon, France; Unité d'Immunologie Virale, Institut Pasteur, Paris, France; INSERM U255, Institut Curie, Paris, France; and Schering Plough, Laboratory for Immunological Research, Dardilly, France. The expression of 3 lymphoid chemokinesmacrophage inflammatory protein-3 (MIP-3), stromal cell-derived factor-1 (SDF-1), and B-cell-attracting chemokine-1 (BCA-1)in the tonsil and the possible correlation between their sites of expression and B-cell localization within this tissue were studied. The results show that all 3 chemokines are produced in the crypts but differ by the nature of the cells that produce them and their location within the crypt. SDF-1 and MIP-3 are produced by epithelial cells, but their secretion is mutually exclusive. Both MIP-3- and SDF-1-expressing cells are in close contact with memory B cells. By contrast, BCA-1-producing cells in the crypt are not epithelial and form clusters colocalized with plasma cells. Altogether, these data suggest that the chemokines produced in the tonsillar crypt may (1) attract memory B cells to antigen and (2) recruit and retain plasma cells and memory B cells within the supportive epithelial microenvironment of the crypt. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Facco, I. Baesso, M. Miorin, M. Bortoli, A. Cabrelle, E. Boscaro, C. Gurrieri, L. Trentin, R. Zambello, F. Calabrese, et al. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis J. Leukoc. Biol., October 1, 2007; 82(4): 946 - 955. [Abstract] [Full Text] [PDF] S. Tugizov, R. Herrera, P. Veluppillai, J. Greenspan, D. Greenspan, and J. M. Palefsky Epstein-Barr Virus (EBV)-Infected Monocytes Facilitate Dissemination of EBV within the Oral Mucosal Epithelium J. Virol., June 1, 2007; 81(11): 5484 - 5496. [Abstract] [Full Text] [PDF] J. 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