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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Inngjerdingen, M. Articles by Maghazachi, A. A. Search for Related Content PubMed PubMed Citation Articles by Inngjerdingen, M. Articles by Maghazachi, A. A. Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 January 2001, Vol. 97, No. 2, pp. 367-375 CHEMOKINES Expression and regulation of chemokine receptors in human natural killer cells Marit Inngjerdingen, Bassam Damaj, and Azzam A. Maghazachi From the Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway, and Tanabe Research Laboratories, San Diego, CA. Using flow cytometric and RNase protection assays, this study examined the expression of chemokine receptors in nonactivated natural killer (NK) cells and compared this expression with NK cells activated with interleukin (IL)-2, which either adhered to plastic flasks (AD) or did not adhere (NA). None of the NK cell subsets expressed CXCR2, CXCR5, or CCR5. The major differences between these cells include increased expression of CXCR1, CCR1, CCR2, CCR4, CCR8, and CX3CR1 in AD when compared to NA or nonactivated NK cells. The chemotactic response to the CXC and CC chemokines correlated with the receptor expression except that all 3 populations responded to GRO-, despite their lack of CXCR2 expression. Pretreatment of these cells with anti-CXCR2 did not inhibit the chemotactic response to GRO-. In addition, nonactivated and NA cells responded to fractalkine, although they lack the expression of CX3CR1. This activity was not inhibited by anti-CX3CR1. Viral macrophage inflammatory protein (vMIP)-I, I-309, and TARC competed with the binding of 125I-309 to AD cells with varying affinities. Transforming growth factor (TGF)-1 but not any other cytokine or chemokine examined including interferon (IFN)-, MIP-3, macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC) or I-309, up-regulated the expression of CXCR3 and CXCR4 on NK cell surface. This is correlated with increased chemotaxis of NK cells treated with TGF-1 toward stromal cell-derived factor (SDF)-1 and interferon-inducible protein-10 (IP-10). Messenger RNA for lymphotactin, RANTES, MIP-1, and MIP-1, but not IP-10, monocyte chemotactic protein (MCP)-1, IL-8, or I-309 was expressed in all 3 NK cell subsets. Our results may have implications for the dissemination of NK cells at the sites of tumor growth or viral replication. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Durudas, J. M. Milush, H.-L. Chen, J. C. Engram, G. Silvestri, and D. L. Sodora Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in Simian Immunodeficiency Virus-Infected Monkeys J. Virol., December 1, 2009; 83(23): 12229 - 12240. [Abstract] [Full Text] [PDF] M. Lagadari, K. Truta-Feles, K. Lehmann, L. Berod, M. Ziemer, M. Idzko, D. Barz, T. Kamradt, A. A. Maghazachi, and J. Norgauer Lysophosphatidic acid inhibits the cytotoxic activity of NK cells: involvement of Gs protein-mediated signaling Int. Immunol., June 1, 2009; 21(6): 667 - 677. [Abstract] [Full Text] [PDF] S. M. Farooq, R. Stillie, M. Svensson, C. 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Biol., May 1, 2004; 75(5): 764 - 771. [Abstract] [Full Text] [PDF] G. C. Hildebrandt, U. A. Duffner, K. M. Olkiewicz, L. A. Corrion, N. E. Willmarth, D. L. Williams, S. G. Clouthier, C. M. Hogaboam, P. R. Reddy, B. B. Moore, et al. A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation Blood, March 15, 2004; 103(6): 2417 - 2426. [Abstract] [Full Text] [PDF] M. Tiefenthaler, S. Hofer, S. Ebner, L. Ivarsson, S. Neyer, M. Herold, G. Mayer, P. Fritsch, and C. Heufler In vitro treatment of dendritic cells with tacrolimus: impaired T-cell activation and IP-10 expression Nephrol. Dial. Transplant., March 1, 2004; 19(3): 553 - 560. [Abstract] [Full Text] [PDF] B. G. Dorner, H. R.C. Smith, A. R. French, S. Kim, J. Poursine-Laurent, D. L. Beckman, J. T. Pingel, R. A. Kroczek, and W. M. Yokoyama Coordinate Expression of Cytokines and Chemokines by NK Cells during Murine Cytomegalovirus Infection J. Immunol., March 1, 2004; 172(5): 3119 - 3131. [Abstract] [Full Text] [PDF] A. Schafer, C. Schulz, M. Eigenthaler, D. Fraccarollo, A. Kobsar, M. Gawaz, G. Ertl, U. Walter, and J. Bauersachs Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion Blood, January 15, 2004; 103(2): 407 - 412. [Abstract] [Full Text] [PDF] L. Stievano, V. Tosello, N. Marcato, A. Rosato, A. Sebelin, L. Chieco-Bianchi, and A. Amadori CD8+{alpha}{beta}+ T Cells That Lack Surface CD5 Antigen Expression Are a Major Lymphotactin (XCL1) Source in Peripheral Blood Lymphocytes J. Immunol., November 1, 2003; 171(9): 4528 - 4538. [Abstract] [Full Text] [PDF] M. Inngjerdingen, B. Rolstad, and J. C. Ryan Activating and Inhibitory Ly49 Receptors Modulate NK Cell Chemotaxis to CXC Chemokine Ligand (CXCL) 10 and CXCL12 J. Immunol., September 15, 2003; 171(6): 2889 - 2895. [Abstract] [Full Text] [PDF] K. Beider, A. Nagler, O. Wald, S. Franitza, M. Dagan-Berger, H. Wald, H. Giladi, S. Brocke, J. Hanna, O. Mandelboim, et al. Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice Blood, September 15, 2003; 102(6): 1951 - 1958. [Abstract] [Full Text] [PDF] V. Veckman, M. Miettinen, S. Matikainen, R. Lande, E. Giacomini, E. M. Coccia, and I. Julkunen Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis J. Leukoc. Biol., September 1, 2003; 74(3): 395 - 402. [Abstract] [Full Text] [PDF] S. Y. Thomas, R. Hou, J. E. Boyson, T. K. Means, C. Hess, D. P. Olson, J. L. Strominger, M. B. Brenner, J. E. Gumperz, S. B. Wilson, et al. CD1d-Restricted NKT Cells Express a Chemokine Receptor Profile Indicative of Th1-Type Inflammatory Homing Cells J. Immunol., September 1, 2003; 171(5): 2571 - 2580. [Abstract] [Full Text] [PDF] J. Hanna, O. Wald, D. Goldman-Wohl, D. Prus, G. Markel, R. Gazit, G. Katz, R. Haimov-Kochman, N. Fujii, S. Yagel, et al. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells Blood, September 1, 2003; 102(5): 1569 - 1577. [Abstract] [Full Text] [PDF] K. Nagaoka, H. Nojima, F. Watanabe, K.-T. Chang, R. K. Christenson, S. Sakai, and K. Imakawa Regulation of Blastocyst Migration, Apposition, and Initial Adhesion by a Chemokine, Interferon {gamma}-inducible Protein 10 kDa (IP-10), during Early Gestation J. Biol. Chem., August 1, 2003; 278(31): 29048 - 29056. [Abstract] [Full Text] [PDF] A. A. Maghazachi G protein-coupled receptors in natural killer cells J. Leukoc. Biol., July 1, 2003; 74(1): 16 - 24. [Abstract] [Full Text] [PDF] A. Gismondi, J. Jacobelli, R. Strippoli, F. Mainiero, A. Soriani, L. Cifaldi, M. Piccoli, L. Frati, and A. Santoni Proline-Rich Tyrosine Kinase 2 and Rac Activation by Chemokine and Integrin Receptors Controls NK Cell Transendothelial Migration J. Immunol., March 15, 2003; 170(6): 3065 - 3073. [Abstract] [Full Text] [PDF] C. Trebst, S. M. Staugaitis, P. Kivisakk, D. Mahad, M. K. Cathcart, B. Tucky, T. Wei, M. R. S. Rani, R. Horuk, K. D. Aldape, et al. CC Chemokine Receptor 8 in the Central Nervous System Is Associated with Phagocytic Macrophages Am. J. Pathol., February 1, 2003; 162(2): 427 - 438. [Abstract] [Full Text] [PDF] M. S. Thomas, S. L. Kunkel, and N. W. Lukacs Differential Role of IFN-{gamma}-Inducible Protein 10 kDa in a Cockroach Antigen-Induced Model of Allergic Airway Hyperreactivity: Systemic Versus Local Effects J. Immunol., December 15, 2002; 169(12): 7045 - 7053. [Abstract] [Full Text] [PDF] K. Dunussi-Joannopoulos, K. Zuberek, K. Runyon, R. G. Hawley, A. Wong, J. Erickson, S. Herrmann, and J. P. Leonard Efficacious immunomodulatory activity of the chemokine stromal cell-derived factor 1 (SDF-1): local secretion of SDF-1 at the tumor site serves as T-cell chemoattractant and mediates T-cell-dependent antitumor responses Blood, August 13, 2002; 100(5): 1551 - 1558. [Abstract] [Full Text] [PDF] D. L. Hodge, W. B. Schill, J. M. Wang, I. Blanca, D. A. Reynolds, J. R. Ortaldo, and H. A. Young IL-2 and IL-12 Alter NK Cell Responsiveness to IFN-{gamma}-Inducible Protein 10 by Down-Regulating CXCR3 Expression J. Immunol., June 15, 2002; 168(12): 6090 - 6098. [Abstract] [Full Text] [PDF] M. T. Borchers, T. Ansay, R. DeSalle, B. L. Daugherty, H. Shen, M. Metzger, N. A. Lee, and J. J. Lee In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration J. Leukoc. Biol., June 1, 2002; 71(6): 1033 - 1041. [Abstract] [Full Text] [PDF] M. Inngjerdingen, K. M. Torgersen, and A. A. Maghazachi Lck is required for stromal cell-derived factor 1alpha (CXCL12)-induced lymphoid cell chemotaxis Blood, May 29, 2002; 99(12): 4318 - 4325. [Abstract] [Full Text] [PDF] A. Glatzel, D. Wesch, F. Schiemann, E. Brandt, O. Janssen, and D. Kabelitz Patterns of Chemokine Receptor Expression on Peripheral Blood {gamma}{delta} T Lymphocytes: Strong Expression of CCR5 Is a Selective Feature of V{delta}2/V{gamma}9 {gamma}{delta} T Cells J. Immunol., May 15, 2002; 168(10): 4920 - 4929. [Abstract] [Full Text] [PDF] M. J. Robertson Role of chemokines in the biology of natural killer cells J. Leukoc. Biol., February 1, 2002; 71(2): 173 - 183. [Abstract] [Full Text] [PDF] K. Kakimi, T. E. Lane, S. Wieland, V. C. Asensio, I. L. Campbell, F. V. Chisari, and L. G. Guidotti Blocking Chemokine Responsive to {gamma}-2/Interferon (IFN)-{gamma} Inducible Protein and Monokine Induced by IFN-{gamma} Activity In Vivo Reduces the Pathogenetic but not the Antiviral Potential of Hepatitis B Virus-specific Cytotoxic T Lymphocytes J. Exp. Med., December 17, 2001; 194(12): 1755 - 1766. [Abstract] [Full Text] [PDF] K. Kakimi, T. E. Lane, F. V. Chisari, and L. G. Guidotti Cutting Edge: Inhibition of Hepatitis B Virus Replication by Activated NK T Cells Does Not Require Inflammatory Cell Recruitment to the Liver J. Immunol., December 15, 2001; 167(12): 6701 - 6705. [Abstract] [Full Text] [PDF] W. W. Hancock, W. Gao, V. Csizmadia, K. L. Faia, N. Shemmeri, and A. D. Luster Donor-Derived Ip-10 Initiates Development of Acute Allograft Rejection J. Exp. Med., April 16, 2001; 193(8): 975 - 980. [Abstract] [Full Text] [PDF]

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