|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 January 2001, Vol. 97, No. 2, pp. 516-522
NEOPLASIA
Bone morphogenetic protein-4 inhibits proliferation and induces
apoptosis of multiple myeloma cells
Öyvind Hjertner,
Henrik Hjorth-Hansen,
Magne Börset,
Carina Seidel,
Anders Waage, and
Anders Sundan
From the Institute of Cancer Research and Molecular
Biology, and the Section of Hematology, Institute of Environmental
Medicine, Norwegian University of Science and Technology, Trondheim,
Norway.
Bone morphogenetic proteins (BMPs) can be isolated from organic
bone matrix and are able to initiate de novo cartilage and bone
formation. Here it is shown that BMP-4 inhibited DNA synthesis in a
dose-dependent manner in 3 IL-6-dependent multiple myeloma (MM) cell
lines (OH-2, IH-1, and ANBL-6). In contrast, no effect on DNA synthesis
was observed in 3 IL-6-independent MM cell lines (JJN-3, U266, and
RPMI 8226). BMP-4 induced cell cycle growth arrest in the
G0/G1 phase in OH-2 and ANBL-6 cells but not in IH-1 cells. BMP-4 induced apoptosis in OH-2 and IH-1 cells, but not
significantly in ANBL-6 cells. Furthermore, BMP-4 induced apoptosis in
freshly isolated MM cells from 4 of 13 patients. In the OH-2 and ANBL-6
cell lines and in a patient sample, immunoblotting showed that BMP-4
down-regulated IL-6-induced tyrosine phosphorylation of Stat3,
suggesting a mechanism for the apparent antagonism between IL-6 and
BMP-4. BMP-4 or analogues may be attractive therapeutic agents in MM
because of possible beneficial effects on both tumor burden and bone disease.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
X. Li, A. Pennisi, and S. Yaccoby
Role of decorin in the antimyeloma effects of osteoblasts
Blood,
July 1, 2008;
112(1):
159 - 168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U.-M. Fagerli, R. U. Holt, T. Holien, T. K. Vaatsveen, F. Zhan, K. W. Egeberg, B. Barlogie, A. Waage, H. Aarset, H. Y. Dai, et al.
Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells
Blood,
January 15, 2008;
111(2):
806 - 815.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Daibata, Y. Nemoto, K. Bandobashi, N. Kotani, M. Kuroda, M. Tsuchiya, H. Okuda, T. Takakuwa, S. Imai, T. Shuin, et al.
Promoter Hypermethylation of the Bone Morphogenetic Protein-6 Gene in Malignant Lymphoma
Clin. Cancer Res.,
June 15, 2007;
13(12):
3528 - 3535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. L. Theriault, T. G. Shepherd, M. L. Mujoomdar, and M. W. Nachtigal
BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells
Carcinogenesis,
June 1, 2007;
28(6):
1153 - 1162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Moll, C. Millet, D. Noel, B. Orsetti, A. Bardin, D. Katsaros, C. Jorgensen, M. Garcia, C. Theillet, P. Pujol, et al.
Chordin is underexpressed in ovarian tumors and reduces tumor cell motility
FASEB J,
February 1, 2006;
20(2):
240 - 250.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Rothhammer, I. Poser, F. Soncin, F. Bataille, M. Moser, and A.-K. Bosserhoff
Bone Morphogenic Proteins Are Overexpressed in Malignant Melanoma and Promote Cell Invasion and Migration
Cancer Res.,
January 15, 2005;
65(2):
448 - 456.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Martinovic, S. Mazic, V. Kisic, N. Basic, J. Jakic-Razumovic, F. Borovecki, D. Batinic, P. Simic, L. Grgurevic, B. Labar, et al.
Expression of Bone Morphogenetic Proteins in Stromal Cells from Human Bone Marrow Long-term Culture
J. Histochem. Cytochem.,
September 1, 2004;
52(9):
1159 - 1167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Buckley, W. Shi, B. Driscoll, A. Ferrario, K. Anderson, and D. Warburton
BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells
Am J Physiol Lung Cell Mol Physiol,
January 1, 2004;
286(1):
L81 - L86.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Schmerer and T. Evans
Primitive erythropoiesis is regulated by Smad-dependent signaling in postgastrulation mesoderm
Blood,
November 1, 2003;
102(9):
3196 - 3205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. G. Shepherd and M. W. Nachtigal
Identification of a Putative Autocrine Bone Morphogenetic Protein-Signaling Pathway in Human Ovarian Surface Epithelium and Ovarian Cancer Cells
Endocrinology,
August 1, 2003;
144(8):
3306 - 3314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Pouliot, A. Blais, and C. Labrie
Overexpression of a Dominant Negative Type II Bone Morphogenetic Protein Receptor Inhibits the Growth of Human Breast Cancer Cells
Cancer Res.,
January 15, 2003;
63(2):
277 - 281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.-T. Brenne, T. Baade Ro, A. Waage, A. Sundan, M. Borset, and H. Hjorth-Hansen
Interleukin-21 is a growth and survival factor for human myeloma cells
Blood,
May 15, 2002;
99(10):
3756 - 3762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Dennler, M.-J. Goumans, and P. ten Dijke
Transforming growth factor {beta} signal transduction
J. Leukoc. Biol.,
May 1, 2002;
71(5):
731 - 740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
