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Related Collections Hemostasis, Thrombosis, and Vascular Biology Brief Reports Clinical Trials and Observations Related Letters in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 February 2001, Vol. 97, No. 3, pp. 812-814 BRIEF REPORT Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura Giovanni Emilia, Giuseppe Longo, Mario Luppi, Giovanna Gandini, Monica Morselli, Leonardo Ferrara, Sergio Amarri, Katia Cagossi, and Giuseppe Torelli From the Department of Medical Sciences, Section of Internal Medicine and Hematology, and Department of Paediatrics, University of Modena, Italy. Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradication with antibiotics, obtained in 12 of 13 infected patients (92.3%), led to a complete response in 4 (33.33%) and to a partial response (platelets 90 × 109/L-120 × 109/L) in 2 (16.66%). The response was maintained for a median of 8.33 months, but 1 patient relapsed 7 months after eradication. Search for H pylori infection seems appropriate in ITP patients at diagnosis. Bacterium eradication provides a new good option for a nonimmunosuppressive treatment in some ITP patients. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letters in Blood Online: Idiopathic thrombocytopenic purpura, Helicobacter pylori infection, and HLA class II alleles Dino Veneri, Michele Gottardi, Elisabetta Guizzardi, Carla Zanuso, Mauro Krampera, Massimo Franchini, Giovanni Emilia, Mario Luppi, Monica Morselli, Giuseppe Longo, and Giuseppe Torelli Blood 2002 100: 1925-1927. [Full Text] [PDF] Helicobacter pylori and idiopathic thrombocytopenic purpura in children Jukka Rajantie and Timo Klemola Blood 2003 101: 1660. [Full Text] [PDF] This article has been cited by other articles: Y. Kumagai, T. Fujita, M. Ozaki, K. Sahashi, M. Ohkura, T. Ohtsu, Y. Arai, Y. Sonehara, and J. L. Nichol Pharmacodynamics and Pharmacokinetics of AMG 531, a Thrombopoiesis-Stimulating Peptibody, in Healthy Japanese Subjects: A Randomized, Placebo-Controlled Study J. Clin. Pharmacol., December 1, 2007; 47(12): 1489 - 1497. [Abstract] [Full Text] [PDF] G. Emilia, M. Luppi, P. Zucchini, M. Morselli, L. Potenza, F. Forghieri, F. Volzone, G. Jovic, G. 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