SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Weinberg, K. Articles by Douek, D. C. Search for Related Content PubMed PubMed Citation Articles by Weinberg, K. Articles by Douek, D. C. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 March 2001, Vol. 97, No. 5, pp. 1458-1466 TRANSPLANTATION Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation Kenneth Weinberg, Bruce R. Blazar, John E. Wagner, Edward Agura, Brenna J. Hill, Monika Smogorzewska, Richard A. Koup, Michael R. Betts, Robert H. Collins, and Daniel C. Douek From the Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA; Division of Bone Marrow Transplantation, Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, MN; Department of Internal Medicine, University of Texas Southwestern Medical Center, and the Sammons Cancer Center, Baylor University Medical Center, Dallas TX. Hematopoietic stem cell transplantation (HSCT) is followed by profound immunodeficiency. Thymic function is necessary for de novo generation of T cells after HSCT. Circulating CD45RA+ naive T-cell levels are predictive of antigen-specific T-cell responses in the absence of graft-versus-host disease (GVHD). These T cells may not represent recent thymic emigrants, since naive T cells may maintain this phenotype if not antigen-activated. To accurately measure thymic output after HSCT and determine the factors that influence thymic function, T-cell receptor excision circles (TRECs) were examined in CD4+ and CD8+ cells from a cross-section of patients following HSCT. TREC levels rose weeks after HSCT and could be detected in patients 6 years after HSCT. TREC levels correlated with the frequency of phenotypically naive T cells, indicating that such cells were not expanded progeny of naive T cells present in the donor graft. Chronic GVHD was the most important factor that predicted low TREC levels even years after HSCT. Patients with a history of resolved GVHD had decreased numbers of TREC, compared with those with no GVHD. Because few adults had no history of GVHD, it was not possible to determine whether age alone inversely correlated with TREC levels. Recipients of cord blood grafts had no evidence of decreased TREC induced by immunosuppressive prophylaxis drugs. Compared with unrelated donor grafts, recipients of matched sibling grafts had higher TREC levels. Collectively, these data suggest that thymopoiesis is inhibited by GVHD. Larger studies will be needed to determine the independent contributions of age and preparative regimen to post-transplant thymopoietic capacity. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. J. Fry Is a little GVHD a good thing? Blood, June 18, 2009; 113(25): 6274 - 6275. [Abstract] [Full Text] [PDF] E. Clave, M. Busson, C. Douay, R. Peffault de Latour, J. Berrou, C. Rabian, M. Carmagnat, V. Rocha, D. Charron, G. Socie, et al. Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation Blood, June 18, 2009; 113(25): 6477 - 6484. [Abstract] [Full Text] [PDF] S. J. Opiela, T. Koru-Sengul, and B. Adkins Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants Blood, May 28, 2009; 113(22): 5635 - 5643. [Abstract] [Full Text] [PDF] B. Neven, S. Leroy, H. Decaluwe, F. Le Deist, C. Picard, D. Moshous, N. Mahlaoui, M. Debre, J.-L. Casanova, L. Dal Cortivo, et al. Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency Blood, April 23, 2009; 113(17): 4114 - 4124. [Abstract] [Full Text] [PDF] J. De Leon-Luis, F. Gamez, P. Pintado, E. Antolin, R. Perez, L. Ortiz-Quintana, and J. Santolaya-Forgas Sonographic Measurements of the Thymus in Male and Female Fetuses J. Ultrasound Med., January 1, 2009; 28(1): 43 - 48. [Abstract] [Full Text] [PDF] K. M. Williams, P. J. Lucas, C. V. Bare, J. Wang, Y.-W. Chu, E. Tayler, V. Kapoor, and R. E. Gress CCL25 increases thymopoiesis after androgen withdrawal Blood, October 15, 2008; 112(8): 3255 - 3263. [Abstract] [Full Text] [PDF] N. Vrisekoop, R. van Gent, A. B. de Boer, S. A. Otto, J. C. C. Borleffs, R. Steingrover, J. M. Prins, T. W. Kuijpers, T. F. W. Wolfs, S. P. M. Geelen, et al. Restoration of the CD4 T Cell Compartment after Long-Term Highly Active Antiretroviral Therapy without Phenotypical Signs of Accelerated Immunological Aging J. Immunol., July 15, 2008; 181(2): 1573 - 1581. [Abstract] [Full Text] [PDF] R. M. Kelly, S. L. Highfill, A. Panoskaltsis-Mortari, P. A. Taylor, R. L. Boyd, G. A. Hollander, and B. R. Blazar Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation Blood, June 15, 2008; 111(12): 5734 - 5744. [Abstract] [Full Text] [PDF] J. S. Sutherland, L. Spyroglou, J. L. Muirhead, T. S. Heng, A. Prieto-Hinojosa, H. M. Prince, A. P. Chidgey, A. P. Schwarer, and R. L. Boyd Enhanced Immune System Regeneration in Humans Following Allogeneic or Autologous Hemopoietic Stem Cell Transplantation by Temporary Sex Steroid Blockade Clin. Cancer Res., February 15, 2008; 14(4): 1138 - 1149. [Abstract] [Full Text] [PDF] E. Castermans, F. Baron, E. Willems, N. Schaaf-Lafontaine, N. Meuris, A. Gothot, J.-F. Vanbellighen, C. Herens, L. Seidel, V. Geenen, et al. Evidence for neo-generation of T cells by the thymus after non-myeloablative conditioning Haematologica, February 1, 2008; 93(2): 240 - 247. [Abstract] [Full Text] [PDF] V. H. Nguyen, S. Shashidhar, D. S. Chang, L. Ho, N. Kambham, M. Bachmann, J. M. Brown, and R. S. Negrin The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation Blood, January 15, 2008; 111(2): 945 - 953. [Abstract] [Full Text] [PDF] K. V. Komanduri, L. S. St. John, M. de Lima, J. McMannis, S. Rosinski, I. McNiece, S. G. Bryan, I. Kaur, S. Martin, E. D. Wieder, et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing Blood, December 15, 2007; 110(13): 4543 - 4551. [Abstract] [Full Text] [PDF] B. Chung, E. P. Dudl, D. Min, L. Barsky, N. Smiley, and K. I. Weinberg Prevention of graft-versus-host disease by anti IL-7R{alpha} antibody Blood, October 15, 2007; 110(8): 2803 - 2810. [Abstract] [Full Text] [PDF] D. Creamer, C. L. Martyn-Simmons, G. Osborne, M. Kenyon, J. R. Salisbury, S. Devereux, A. Pagliuca, A. Y. Ho, G. J. Mufti, and A. W. P. du Vivier Eczematoid Graft-vs-Host Disease: A Novel Form of Chronic Cutaneous Graft-vs-Host Disease and Its Response to Psoralen UV-A Therapy Arch Dermatol, September 1, 2007; 143(9): 1157 - 1162. [Abstract] [Full Text] [PDF] Y. Zhang, E. Hexner, D. Frank, and S. G. Emerson CD4+ T Cells Generated De Novo from Donor Hemopoietic Stem Cells Mediate the Evolution from Acute to Chronic Graft-versus-Host Disease J. Immunol., September 1, 2007; 179(5): 3305 - 3314. [Abstract] [Full Text] [PDF] S. Smith-Berdan, D. Gille, I. L. Weissman, and J. L. Christensen Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells Blood, August 15, 2007; 110(4): 1370 - 1378. [Abstract] [Full Text] [PDF] D. B. Kohn Gene therapy as salvage Blood, July 1, 2007; 110(1): 4 - 4. [Full Text] [PDF] J. Gorski, X. Chen, M. Gendelman, M. Yassai, A. Krueger, E. Tivol, B. Logan, R. Komorowski, S. Vodanovic-Jankovic, and W. R. Drobyski Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment Blood, June 15, 2007; 109(12): 5502 - 5510. [Abstract] [Full Text] [PDF] M. Cavazzana-Calvo, F. Carlier, F. Le Deist, E. Morillon, P. Taupin, D. Gautier, I. Radford-Weiss, S. Caillat-Zucman, B. Neven, S. Blanche, et al. Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell-immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype Blood, May 15, 2007; 109(10): 4575 - 4581. [Abstract] [Full Text] [PDF] K. I. Weinberg ProTECtion from posttransplantation immune deficiency? Blood, May 1, 2007; 109(9): 3617 - 3618. [Full Text] [PDF] M. M. Hauri-Hohl, M. P. Keller, J. Gill, K. Hafen, E. Pachlatko, T. Boulay, A. Peter, G. A. Hollander, and W. Krenger Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation Blood, May 1, 2007; 109(9): 4080 - 4088. [Abstract] [Full Text] [PDF] S. W. Rossi, L. T. Jeker, T. Ueno, S. Kuse, M. P. Keller, S. Zuklys, A. V. Gudkov, Y. Takahama, W. Krenger, B. R. Blazar, et al. Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells Blood, May 1, 2007; 109(9): 3803 - 3811. [Abstract] [Full Text] [PDF] E.-J. Wils, E. Braakman, G. M. G. M. Verjans, E. J. C. Rombouts, A. E. C. Broers, H. G. M. Niesters, G. Wagemaker, F. J. T. Staal, B. Lowenberg, H. Spits, et al. Flt3 Ligand Expands Lymphoid Progenitors Prior to Recovery of Thymopoiesis and Accelerates T Cell Reconstitution after Bone Marrow Transplantation J. Immunol., March 15, 2007; 178(6): 3551 - 3557. [Abstract] [Full Text] [PDF] Y. Sakoda, D. Hashimoto, S. Asakura, K. Takeuchi, M. Harada, M. Tanimoto, and T. Teshima Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease Blood, February 15, 2007; 109(4): 1756 - 1764. [Abstract] [Full Text] [PDF] B. R. Blazar, D. J. Weisdorf, T. DeFor, A. Goldman, T. Braun, S. Silver, and J. L. M. Ferrara Phase 1/2 randomized, placebo-control trial of palifermin to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) Blood, November 1, 2006; 108(9): 3216 - 3222. [Abstract] [Full Text] [PDF] J. A. Borghans, R. G. Bredius, M. D. Hazenberg, H. Roelofs, E. C. Jol-van der Zijde, J. Heidt, S. A. Otto, T. W. Kuijpers, W. E. Fibbe, J. M. Vossen, et al. Early determinants of long-term T-cell reconstitution after hematopoietic stem cell transplantation for severe combined immunodeficiency Blood, July 15, 2006; 108(2): 763 - 769. [Abstract] [Full Text] [PDF] S. S. T.-D. Ravin, D. R. Kennedy, N. Naumann, J. S. Kennedy, U. Choi, B. J. Hartnett, G. F. Linton, N. L. Whiting-Theobald, P. F. Moore, W. Vernau, et al. Correction of canine X-linked severe combined immunodeficiency by in vivo retroviral gene therapy Blood, April 15, 2006; 107(8): 3091 - 3097. [Abstract] [Full Text] [PDF] S. Z. Pavletic, S. L. Carter, N. A. Kernan, J. Henslee-Downey, A. M. Mendizabal, E. Papadopoulos, R. Gingrich, J. Casper, S. Yanovich, D. Weisdorf, et al. Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation Blood, November 1, 2005; 106(9): 3308 - 3313. [Abstract] [Full Text] [PDF] S. J. Lee New approaches for preventing and treating chronic graft-versus-host disease Blood, June 1, 2005; 105(11): 4200 - 4206. [Abstract] [Full Text] [PDF] E. Clave, V. Rocha, K. Talvensaari, M. Busson, C. Douay, M.-L. Appert, C. Rabian, M. Carmagnat, F. Garnier, A. Filion, et al. Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation Blood, March 15, 2005; 105(6): 2608 - 2613. [Abstract] [Full Text] [PDF] C. J. Workman and D. A. A. Vignali Negative Regulation of T Cell Homeostasis by Lymphocyte Activation Gene-3 (CD223) J. Immunol., January 15, 2005; 174(2): 688 - 695. [Abstract] [Full Text] [PDF] X. Chen, R. Barfield, E. Benaim, W. Leung, J. Knowles, D. Lawrence, M. Otto, S. A. Shurtleff, G. A. M. Neale, F. G. Behm, et al. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients Blood, January 15, 2005; 105(2): 886 - 893. [Abstract] [Full Text] [PDF] C Kayser, F L Alberto, N P da Silva, and L E. Andrade Decreased number of T cells bearing TCR rearrangement excision circles (TREC) in active recent onset systemic lupus erythematosus Lupus, December 1, 2004; 13(12): 906 - 911. [Abstract] [PDF] T. Iwasaki Recent Advances in the Treatment of Graft-Versus-Host Disease Clin. Med. Res., November 1, 2004; 2(4): 243 - 252. [Abstract] [Full Text] [PDF] T. J. Fry, M. Sinha, M. Milliron, Y.-W. Chu, V. Kapoor, R. E. Gress, E. Thomas, and C. L. Mackall Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution Blood, November 1, 2004; 104(9): 2794 - 2800. [Abstract] [Full Text] [PDF] Y. Miura, C. J. Thoburn, E. C. Bright, M. L. Phelps, T. Shin, E. C. Matsui, W. H. Matsui, S. Arai, E. J. Fuchs, G. B. Vogelsang, et al. Association of Foxp3 regulatory gene expression with graft-versus-host disease Blood, October 1, 2004; 104(7): 2187 - 2193. [Abstract] [Full Text] [PDF] T. Imado, T. Iwasaki, Y. Kataoka, T. Kuroiwa, H. Hara, J. Fujimoto, and H. Sano Hepatocyte growth factor preserves graft-versus-leukemia effect and T-cell reconstitution after marrow transplantation Blood, September 1, 2004; 104(5): 1542 - 1549. [Abstract] [Full Text] [PDF] W. Krenger, H. Schmidlin, G. Cavadini, and G. A. Hollander On the Relevance of TCR Rearrangement Circles as Molecular Markers for Thymic Output during Experimental Graft-versus-Host Disease J. Immunol., June 15, 2004; 172(12): 7359 - 7367. [Abstract] [Full Text] [PDF] K. Yamashita, U. Choi, P. C. Woltz, S. F. Foster, M. C. Sneller, F. T. Hakim, D. H. Fowler, M. R. Bishop, S. Z. Pavletic, M. Tamari, et al. Severe chronic graft-versus-host disease is characterized by a preponderance of CD4+ effector memory cells relative to central memory cells Blood, May 15, 2004; 103(10): 3986 - 3988. [Abstract] [Full Text] [PDF] F. J. Clark, R. Gregg, K. Piper, D. Dunnion, L. Freeman, M. Griffiths, G. Begum, P. Mahendra, C. Craddock, P. Moss, et al. Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells Blood, March 15, 2004; 103(6): 2410 - 2416. [Abstract] [Full Text] [PDF] M. Gendelman, T. Hecht, B. Logan, S. Vodanovic-Jankovic, R. Komorowski, and W. R. Drobyski Host Conditioning Is a Primary Determinant in Modulating the Effect of IL-7 on Murine Graft-versus-Host Disease J. Immunol., March 1, 2004; 172(5): 3328 - 3336. [Abstract] [Full Text] [PDF] N. J. Chao, S. G. Emerson, and K. I. Weinberg Stem Cell Transplantation (Cord Blood Transplants) Hematology, January 1, 2004; 2004(1): 354 - 371. [Abstract] [Full Text] [PDF] J.-F. Poulin, M. Sylvestre, P. Champagne, M.-L. Dion, N. Kettaf, A. Dumont, M. Lainesse, P. Fontaine, D.-C. Roy, C. Perreault, et al. Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease Blood, December 15, 2003; 102(13): 4600 - 4607. [Abstract] [Full Text] [PDF] M. K. Gandhi, M. R. Wills, G. Okecha, E. K. Day, R. Hicks, R. E. Marcus, J. G. P. Sissons, and A. J. Carmichael Late diversification in the clonal composition of human cytomegalovirus-specific CD8+ T cells following allogeneic hemopoietic stem cell transplantation Blood, November 1, 2003; 102(9): 3427 - 3438. [Abstract] [Full Text] [PDF] E. Bachar-Lustig, S. Reich-Zeliger, and Y. Reisner Anti-third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose Blood, September 15, 2003; 102(6): 1943 - 1950. [Abstract] [Full Text] [PDF] A. E. C. Broers, S. J. Posthumus-van Sluijs, H. Spits, B. van der Holt, B. Lowenberg, E. Braakman, and J. J. Cornelissen Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants Blood, August 15, 2003; 102(4): 1534 - 1540. [Abstract] [Full Text] [PDF] C. Arber, A. BitMansour, T. E. Sparer, J. P. Higgins, E. S. Mocarski, I. L. Weissman, J. A. Shizuru, and J. M. Y. Brown Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation Blood, July 15, 2003; 102(2): 421 - 428. [Abstract] [Full Text] [PDF] E. Orsini, R. Bellucci, E. P. Alyea, R. Schlossman, C. Canning, S. McLaughlin, P. Ghia, K. C. Anderson, and J. Ritz Expansion of Tumor-specific CD8+ T Cell Clones in Patients with Relapsed Myeloma after Donor Lymphocyte Infusion Cancer Res., May 15, 2003; 63(10): 2561 - 2568. [Abstract] [Full Text] [PDF] M. Sarzotti, D. D. Patel, X. Li, D. A. Ozaki, S. Cao, S. Langdon, R. E. Parrott, K. Coyne, and R. H. Buckley T Cell Repertoire Development in Humans with SCID After Nonablative Allogeneic Marrow Transplantation J. Immunol., March 1, 2003; 170(5): 2711 - 2718. [Abstract] [Full Text] [PDF] M. Malphettes, G. Carcelain, P. Saint-Mezard, V. Leblond, H. K. Altes, J.-P. Marolleau, P. Debre, J.-C. Brouet, J.-P. Fermand, and B. Autran Evidence for naive T-cell repopulation despite thymus irradiation after autologous transplantation in adults with multiple myeloma: role of ex vivo CD34+ selection and age Blood, March 1, 2003; 101(5): 1891 - 1897. [Abstract] [Full Text] [PDF] N. Dainiak, J. K. Waselenko, J. O. Armitage, T. J. MacVittie, and A. M. Farese The Hematologist and Radiation Casualties Hematology, January 1, 2003; 2003(1): 473 - 496. [Abstract] [Full Text] [PDF] M. L. Sinha, T. J. Fry, D. H. Fowler, G. Miller, and C. L. Mackall Interleukin 7 worsens graft-versus-host disease Blood, September 18, 2002; 100(7): 2642 - 2649. [Abstract] [Full Text] [PDF] S. R. Lewin, G. Heller, L. Zhang, E. Rodrigues, E. Skulsky, M. R. M. van den Brink, T. N. Small, N. A. Kernan, R. J. O'Reilly, D. D. Ho, et al. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations Blood, August 28, 2002; 100(6): 2235 - 2242. [Abstract] [Full Text] [PDF] M. Eyrich, T. Croner, C. Leiler, P. Lang, P. Bader, T. Klingebiel, D. Niethammer, and P. G. Schlegel Distinct contributions of CD4+ and CD8+ naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors Blood, August 13, 2002; 100(5): 1915 - 1918. [Abstract] [Full Text] [PDF] S. Rossi, B. R. Blazar, C. L. Farrell, D. M. Danilenko, D. L. Lacey, K. I. Weinberg, W. Krenger, and G. A. Hollander Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease Blood, June 28, 2002; 100(2): 682 - 691. [Abstract] [Full Text] [PDF] R. Bellucci, E. P. Alyea, E. Weller, A. Chillemi, E. Hochberg, C. J. Wu, C. Canning, R. Schlossman, R. J. Soiffer, K. C. Anderson, et al. Immunologic effects of prophylactic donor lymphocyte infusion after allogeneic marrow transplantation for multiple myeloma Blood, May 29, 2002; 99(12): 4610 - 4617. [Abstract] [Full Text] [PDF] P. Ye and D. E. Kirschner Reevaluation of T Cell Receptor Excision Circles as a Measure of Human Recent Thymic Emigrants J. Immunol., May 15, 2002; 168(10): 4968 - 4979. [Abstract] [Full Text] [PDF] M. D. Hazenberg, S. A. Otto, E. S. de Pauw, H. Roelofs, W. E. Fibbe, D. Hamann, and F. Miedema T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events Blood, May 1, 2002; 99(9): 3449 - 3453. [Abstract] [Full Text] [PDF] K. Talvensaari, E. Clave, C. Douay, C. Rabian, L. Garderet, M. Busson, F. Garnier, D. Douek, E. Gluckman, D. Charron, et al. A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation Blood, February 15, 2002; 99(4): 1458 - 1464. [Abstract] [Full Text] [PDF] R. Chakraverty, K. Peggs, R. Chopra, D. W. Milligan, P. D. Kottaridis, S. Verfuerth, J. Geary, D. Thuraisundaram, K. Branson, S. Chakrabarti, et al. Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen Blood, February 1, 2002; 99(3): 1071 - 1078. [Abstract] [Full Text] [PDF] J. R. Wingard, G. B. Vogelsang, and H. J. Deeg Stem Cell Transplantation: Supportive Care and Long-Term Complications Hematology, January 1, 2002; 2002(1): 422 - 444. [Abstract] [Full Text] J. Storek, A. Joseph, G. Espino, M. A. Dawson, D. C. Douek, K. M. Sullivan, M. E. D. Flowers, P. Martin, G. Mathioudakis, R. A. Nash, et al. Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation Blood, December 15, 2001; 98(13): 3505 - 3512. [Abstract] [Full Text] [PDF] D. C. Douek, M. R. Betts, B. J. Hill, S. J. Little, R. Lempicki, J. A. Metcalf, J. Casazza, C. Yoder, J. W. Adelsberger, R. A. Stevens, et al. Evidence for Increased T Cell Turnover and Decreased Thymic Output in HIV Infection J. Immunol., December 1, 2001; 167(11): 6663 - 6668. [Abstract] [Full Text] [PDF] B. Chung, L. Barbara-Burnham, L. Barsky, and K. Weinberg Radiosensitivity of thymic interleukin-7 production and thymopoiesis after bone marrow transplantation Blood, September 1, 2001; 98(5): 1601 - 1606. [Abstract] [Full Text] [PDF] E. P. Hochberg, A. C. Chillemi, C. J. Wu, D. Neuberg, C. Canning, K. Hartman, E. P. Alyea, R. J. Soiffer, S. A. Kalams, and J. Ritz Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults Blood, August 15, 2001; 98(4): 1116 - 1121. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020