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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gorochov, G. Articles by Debré, P. Search for Related Content PubMed PubMed Citation Articles by Gorochov, G. Articles by Debré, P. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 March 2001, Vol. 97, No. 6, pp. 1787-1795 IMMUNOBIOLOGY Down-regulation of CD8+ T-cell expansions in patients with human immunodeficiency virus infection receiving highly active combination therapy Guy Gorochov, Avidan U. Neumann, Christophe Parizot, Taisheng Li, Christine Katlama, and Patrice Debré From the Laboratoire d'Immunologie Cellulaire, Hopital Pitié-Salpétrière; the Department of Infectious Diseases and Tropical Medicine, Hopital Pitié-Salpétrière, Paris, France; and the Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. Analysis of T-cell receptor (TCR) repertoire usage made by peripheral T lymphocytes during the chronic phase of HIV-1 infection has revealed the presence of clonal expansions of CD8 T cells that are also shown to be largely HIV-specific. Yet, it remains unclear whether the global repertoire perturbation observed during the chronic phase of the infection is also HIV-related and reversible in the long term with the application of highly active antiretroviral therapy. Furthermore, the diversity and the stability of repertoire usage after a relapse of viral replication were never examined. Eight patients were observed longitudinally up to 31 months under triple-association therapy. When viral replication was steadily suppressed, CD8 repertoires were significantly stabilized. Conversely, in situations of incomplete or only transient viral suppression, persistence or rebound in repertoire perturbation was observed. Finally, a T-cell response remarkably different from baseline, as reflected by a repertoire switch, was generated after the discontinuation of highly active therapy. In conclusion, a sustained control of HIV replication correlated with profound modifications of the CD8 repertoire usage. These data also suggested that autovaccination by the withdrawal of antiviral drugs would result in the selection and expansion of T-cell clones that were not necessarily dominant before the onset of treatment. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Yang, T. Dong, E. Turnbull, S. Ranasinghe, B. Ondondo, N. Goonetilleke, N. Winstone, K. di Gleria, P. Bowness, C. Conlon, et al. Broad TCR Usage in Functional HIV-1-Specific CD8+ T Cell Expansions Driven by Vaccination during Highly Active Antiretroviral Therapy J. Immunol., July 1, 2007; 179(1): 597 - 606. [Abstract] [Full Text] [PDF] C. Rizzo, G. Brancaccio, D. De Vito, and G. Rizzo Efficacy of autovaccination therapy on post-coronary artery bypass grafting methicillin-resistant Staphylococcus aureus mediastinitis Interactive CardioVascular and Thoracic Surgery, April 1, 2007; 6(2): 228 - 229. [Abstract] [Full Text] [PDF] D. Meyer-Olson, K. W. Brady, M. T. Bartman, K. M. O'Sullivan, B. C. Simons, J. A. Conrad, C. B. Duncan, S. Lorey, A. Siddique, R. Draenert, et al. Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire Blood, March 15, 2006; 107(6): 2373 - 2383. [Abstract] [Full Text] [PDF] M. Miyara, Z. Amoura, C. Parizot, C. Badoual, K. Dorgham, S. Trad, M. Kambouchner, D. Valeyre, C. Chapelon-Abric, P. Debre, et al. The immune paradox of sarcoidosis and regulatory T cells J. Exp. Med., February 21, 2006; 203(2): 359 - 370. [Abstract] [Full Text] [PDF] D. N. Posnett, M. E. Engelhorn, and A. N. Houghton Antiviral T cell responses: phalanx or multipronged attack? J. Exp. Med., June 20, 2005; 201(12): 1881 - 1884. [Abstract] [Full Text] [PDF] E Hodges, M T Krishna, C Pickard, and J L Smith Diagnostic role of tests for T cell receptor (TCR) genes J. Clin. Pathol., January 1, 2003; 56(1): 1 - 11. [Abstract] [Full Text] [PDF] O. Benveniste, P. Cherin, T. Maisonobe, R. Merat, O. Chosidow, L. Mouthon, L. Guillevin, A. Flahault, M.-C. Burland, D. Klatzmann, et al. Severe Perturbations of the Blood T Cell Repertoire in Polymyositis, But Not Dermatomyositis Patients J. Immunol., September 15, 2001; 167(6): 3521 - 3529. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020