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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Karanu, F. N. Articles by Bhatia, M. Search for Related Content PubMed PubMed Citation Articles by Karanu, F. N. Articles by Bhatia, M. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2001, Vol. 97, No. 7, pp. 1960-1967 HEMATOPOIESIS Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells Francis N. Karanu, Barbara Murdoch, Tomoyuki Miyabayashi, Mitsuhara Ohno, Masahide Koremoto, Lisa Gallacher, Dongmei Wu, Akira Itoh, Seiji Sakano, and Mickie Bhatia From Developmental Stem Cell Biology, The John P. Robarts Research Institute, London, ON, Canada; Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada; Second Research Department, Central Technology Laboratory, Asahi Chemical Industry, Fuji, Shizuoka, Japan. Delta-mediated Notch signaling controls cell fate decisions during invertebrate and murine development. However, in the human, functional roles for Delta have yet to be described. This study reports the characterization of Delta-1 and Delta-4 in the human. Human Delta-4 was found to be expressed in a wide range of adult and fetal tissues, including sites of hematopoiesis. Subsets of immature hematopoietic cells, along with stromal and endothelial cells that support hematopoiesis, were shown to express Notch and both Delta-1 and Delta-4. Soluble forms of human Delta-1 (hDelta-1) and hDelta-4 proteins were able to augment the proliferation of primitive human hematopoietic progenitors in vitro. Intravenous transplantation of treated cultures into immune-deficient mice revealed that hDelta-1 is capable of expanding pluripotent human hematopoietic repopulating cells detected in vivo. This study provides the first evidence for a role of Delta ligands as a mitogenic regulator of primitive hematopoietic cells in the human. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. FU, K.-I. KATSUBE, and S. TOHDA Transition of Cleaved Notch1 and Gene Expression Changes in Myeloblastic Leukemia Cells Stimulated with Notch Ligands Anticancer Res, October 1, 2009; 29(10): 3967 - 3970. [Abstract] [Full Text] [PDF] K. Haraguchi, T. Suzuki, N. Koyama, K. Kumano, F. Nakahara, A. Matsumoto, Y. Yokoyama, M. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020