|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 July 2001, Vol. 98, No. 1, pp. 140-145
IMMUNOBIOLOGY
Surgical and physical stress increases circulating blood
dendritic cell counts independently of monocyte counts
Christopher S. K. Ho,
Jose
Alejandro López,
Slavica Vuckovic,
Christopher M. Pyke,
Richard L. Hockey, and
Derek N. J. Hart
From the Dendritic Cell Laboratory, Mater Medical
Research Institute; University of Queensland Department of Surgery,
Mater Misericordiae Hospitals Campus; and Clinical Epidemiology Centre,
Mater Misericordiae Hospitals; all of Brisbane, Australia.
Dendritic cells (DCs) are specialized antigen-presenting cells that
have the unique ability to initiate a primary immune response. The
effect of physiologic stress on circulating blood DCs has thus far not
been studied. In this study, we applied a recently developed method of
counting blood DCs to test the hypothesis that significant stress to
the body such as surgery and exercise might induce measurable changes
in the DC numbers, subsets, phenotype, and function. Twenty-six
patients scheduled for elective laparoscopic cholecystectomy, 4 for elective hysterectomy, 56 controls, and 5 volunteers who underwent
a stress exercise test were enrolled in the study. Absolute DC
counts increased acutely (71.7% ± 11% [SEM],
P = .0001) in response to the stress of surgery and
dropped below preoperative levels ( 25% ± 14% [SEM],
P = .05) on days 2-3. The perioperative DC subset balance
remained constant. Interestingly, DC counts changed independently of
monocyte counts. Exercise also induced a rise in DC counts but
coincidentally with monocyte counts. Surprisingly, no phenotypic
or functional activation of DCs was seen in either stress situations in
vivo. DCs are rapidly mobilized into the circulation in response to
surgical and exercise stress, which may serve to prepare the
host's immune defenses against trauma. The independent regulation of
the DC and monocyte counts reinforces the distinction between these 2 cell populations.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Okutsu, Y. Yoshida, X. Zhang, A. Tamagawa, T. Ohkubo, I. Tsuji, and R. Nagatomi
Exercise training enhances in vivo tuberculosis purified protein derivative response in the elderly
J Appl Physiol,
June 1, 2008;
104(6):
1690 - 1696.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E Smolewska, J Stanczyk, H Brozik, M Biernacka-Zielinska, B Cebula, T Robak, and P Smolewski
Distribution and clinical significance of blood dendritic cells in children with juvenile idiopathic arthritis
Ann Rheum Dis,
June 1, 2008;
67(6):
762 - 768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Diao, E. Winter, C. Cantin, W. Chen, L. Xu, D. Kelvin, J. Phillips, and M. S. Cattral
In Situ Replication of Immediate Dendritic Cell (DC) Precursors Contributes to Conventional DC Homeostasis in Lymphoid Tissue.
J. Immunol.,
June 15, 2006;
176(12):
7196 - 7206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Smith, R. L. Gamelli, S. B. Jones, and R. Shankar
Immunologic responses to critical injury and sepsis.
J Intensive Care Med,
May 1, 2006;
21(3):
160 - 172.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Athanassopoulos, L. M.B. Vaessen, A. H.M.M. Balk, J. J.M. Takkenberg, A. P.W.M. Maat, W. Weimar, and A. J.J.C. Bogers
Impaired circulating dendritic cell reconstitution identifies rejecting recipients after clinical heart transplantation independent of rejection therapy
Eur. J. Cardiothorac. Surg.,
May 1, 2005;
27(5):
783 - 789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Saint-Mezard, C. Chavagnac, S. Bosset, M. Ionescu, E. Peyron, D. Kaiserlian, J.-F. Nicolas, and F. Berard
Psychological Stress Exerts an Adjuvant Effect on Skin Dendritic Cell Functions In Vivo
J. Immunol.,
October 15, 2003;
171(8):
4073 - 4080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Vuckovic, M. Kim, D. Khalil, C. J. Turtle, G. V. Crosbie, N. Williams, L. Brown, K. Williams, C. Kelly, P. Stravos, et al.
Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression
Blood,
March 15, 2003;
101(6):
2314 - 2317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. P. A. MacDonald, D. J. Munster, G. J. Clark, A. Dzionek, J. Schmitz, and D. N. J. Hart
Characterization of human blood dendritic cell subsets
Blood,
December 15, 2002;
100(13):
4512 - 4520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Osugi, S. Vuckovic, and D. N. J. Hart
Myeloid blood CD11c+ dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes
Blood,
September 26, 2002;
100(8):
2858 - 2866.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M. Kantarjian, S. O'Brien, J. E. Cortes, S. A. Giralt, M. B. Rios, J. Shan, F. J. Giles, D. A. Thomas, S. Faderl, M. De Lima, et al.
Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia
Blood,
August 13, 2002;
100(5):
1590 - 1595.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. K. Ho, D. Munster, C. M. Pyke, D. N. J. Hart, and J. A. Lopez
Spontaneous generation and survival of blood dendritic cells in mononuclear cell culture without exogenous cytokines
Blood,
April 15, 2002;
99(8):
2897 - 2904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Febbraio, R. L. Starkie, S. G. Rhind, and P. N. Shek
The Cellular Origin of Plasma Cytokine Expression After Acute Exercise
Am J Physiol Regulatory Integrative Comp Physiol,
April 1, 2002;
282(4):
R1253 - R1257.
[Full Text]
[PDF]
|
|
|
| |
