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Blood, 1 July 2001, Vol. 98, No. 1, pp. 241-243
BRIEF REPORT
Stable remission after administration of the receptor tyrosine
kinase inhibitor SU5416 in a patient with refractory
acute myeloid leukemia
Rolf M. Mesters,
Teresa Padró,
Ralf Bieker,
Martin Steins,
Michael Kreuter,
Michael Göner,
Stephen Kelsey,
Paul Scigalla,
Walter Fiedler,
Thomas Büchner, and
Wolfgang E. Berdel
From the Department of Medicine/Hematology and
Oncology, University of Muenster, Germany; the Department of
Oncology/Hematology, University Hospital Eppendorf, Hamburg,
Germany; and Sugen, South San Francisco, CA.
The small molecule receptor tyrosine kinase (RTK) inhibitor SU5416
targets the vascular endothelial growth factor receptor 2 and the stem
cell factor receptor c-kit. Herein is described the successful
treatment of a 65-year-old woman with SU5416, in second relapse of
acute myeloid leukemia (AML) and refractory toward standard
chemotherapy regimens. After 12 weeks of treatment with SU5416, the
blast cell counts (blood and bone marrow) decreased to undetectable
levels and the peripheral blood cell counts normalized with the
exception of the platelet count (50-80 × 109/L
[50-80 × 103/µL]). The duration of the
remission is longer than 4 months during maintenance therapy with
SU5416. Microvessel density in the patient's bone marrow dropped from
33.4 to 12.3 microvessels/×500-field 8 weeks after SU5416
administration and remains in the normal range. This is the first
report of a stable remission achieved after administration of the RTK
inhibitor SU5416 in a patient with AML relapse.
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