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Blood, 15 November 2001, Vol. 98, No. 10, pp. 3159-3161
BRIEF REPORT
Role of 4 platelet membrane glycoprotein polymorphisms on
experimental arterial thrombus formation in men
Yves Cadroy,
Kjell S. Sakariassen,
Jean-Paul Charlet,
Claire Thalamas,
Bernard Boneu, and
Pierre Sie
From the Laboratoire de Recherche sur
l'Hémostase et la Thrombose, Pavillon Lefèbvre, and Centre
d'Investigation Clinique, CHU Purpan, Cedex, France;
Department of Biology, Division of General Physiology, University of
Oslo, Oslo, Norway; and Département d'Informatique,
Hôpital La Grave, Toulouse, France.
This study investigates whether the polymorphisms of 3 important
platelet receptors affected experimental thrombus formation in
men. Forty healthy male volunteers randomly recruited were genotyped for the variable number of tandem repeat (VNTR) of GPIb , the  5T/C polymorphism in the Kozak sequence of GPIb, the 807C/T polymorphism of GPIa, and the PlA1/PlA2
polymorphism of GPIIb/IIIa. Platelet thrombus formation was induced ex
vivo by exposing a collagen-coated coverslip in a parallel plate
perfusion chamber to native blood for 4 minutes. The shear rates at the
collagen surface were 650 and 2600 s 1. At 2600 s1 platelet thrombus formation was significantly related
only to the 807C/T polymorphism. In contrast, at 650 s1
thrombus formation was significantly altered only by the Kozak sequence
polymorphism. The VNTR and the PlA1/PlA2
polymorphisms did not influence thrombus formation. Thus, platelet thrombus formation is significantly influenced by genetic variations of
the GPIb and GPIa receptors. The effect of these polymorphisms was
dependent on the blood flow rate.
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