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Blood, 15 November 2001, Vol. 98, No. 10, pp. 3162-3164
BRIEF REPORT
Correlation of peripheral blood
OX40+(CD134+) T
cells with chronic graft-versus-host disease in patients who underwent
allogeneic hematopoietic stem cell transplantation
Ai Kotani,
Takayuki Ishikawa,
Yumi Matsumura,
Tatsuo Ichinohe,
Hitoshi Ohno,
Toshiyuki Hori, and
Takashi Uchiyama
From the Department of Hematology/Oncology, Department
of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto,
Japan.
There is no reliable laboratory indicator of the onset of chronic
graft-versus-host disease (cGVHD). This study looks at whether the
expression of OX40, a member of the tumor necrosis factor receptor
family, is related to the development of cGVHD in patients who
underwent allogeneic hematopoietic stem cell transplantation. Peripheral blood mononuclear cells from 22 patients after day 100 were
subjected to multicolor flow cytometry. The percentages of both
OX40+CD4+ and OX40+CD8+
T cells were significantly higher in patients with cGVHD than those
without (P < .0001 and P = .001,
respectively). Serial analyses showed that
OX40+CD4+ T cells elevated before the onset of
cGVHD and closely correlated with the therapeutic response. The
expression of CD25, CD69, and HLA-DR was partially detectable on
OX40+ T cells. These results indicate that serial
measurement of OX40+ T cells is useful for predicting the
onset as well as the therapeutic response of cGVHD and raise a
possibility that the OX40/gp34 system is involved in the pathogenesis
of cGVHD.
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