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Blood, 1 December 2001, Vol. 98, No. 12, pp. 3486-3488
BRIEF REPORT
Successful allogeneic engraftment of mismatched unrelated cord
blood following a nonmyeloablative preparative regimen
David A. Rizzieri,
Gwynn D. Long,
James J. Vredenburgh,
Christina Gasparetto,
Ashley Morris,
Timothy T. Stenzel,
Patti Davis, and
Nelson J. Chao
From the Marrow and Stem Cell Transplantation Program,
Duke University Medical Center, Durham, NC.
Reduction in the toxicity of allogeneic transplantation with
nonmyeloablative induction regimens has expanded the scope of practice
to older and more debilitated patients. However, the limited
availability of matched sibling donors requires that alternative donor
sources be investigated. Reported here are 2 cases of patients with
advanced hematologic malignancies without matched siblings, partially
matched family members, or matched unrelated donors who successfully
underwent nonmyeloablative conditioning therapy followed by infusion of
partially matched, unrelated-donor cord blood cells. The
patients are in remission and remain 100% donor as assessed by short
tandem repeat analysis of the marrow 6 and 12 months following transplantation.

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