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Blood, 1 December 2001, Vol. 98, No. 12, pp. 3486-3488

BRIEF REPORT

Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen

David A. Rizzieri, Gwynn D. Long, James J. Vredenburgh, Christina Gasparetto, Ashley Morris, Timothy T. Stenzel, Patti Davis, and Nelson J. Chao

From the Marrow and Stem Cell Transplantation Program, Duke University Medical Center, Durham, NC.

Reduction in the toxicity of allogeneic transplantation with nonmyeloablative induction regimens has expanded the scope of practice to older and more debilitated patients. However, the limited availability of matched sibling donors requires that alternative donor sources be investigated. Reported here are 2 cases of patients with advanced hematologic malignancies without matched siblings, partially matched family members, or matched unrelated donors who successfully underwent nonmyeloablative conditioning therapy followed by infusion of partially matched, unrelated-donor cord blood cells. The patients are in remission and remain 100% donor as assessed by short tandem repeat analysis of the marrow 6 and 12 months following transplantation.

© 2001 by The American Society of Hematology.
 

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