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Blood, 15 December 2001, Vol. 98, No. 13, pp. 3853-3856
BRIEF REPORT
Identification and characterization of cis elements in
the STAT3 gene regulating STAT3 and STAT3 messenger RNA
splicing
Huang Shao,
Andres J. Quintero, and
David J. Tweardy
From the Section of Infectious Diseases, Department of
Medicine, Baylor College of Medicine, Houston, TX; and the University
of Pittsburgh Cancer Institute, PA.
Signal transducer and activator of transcription 3 (STAT3) is an
oncogene and a critical regulator of multiple cell-fate decisions, including myeloid cell differentiation. Two isoforms of STAT3 have been
identified:  (p92) and  (p83). These differ structurally in their
C-terminal transactivation domains, resulting in distinct functional
activities. The cis genetic elements that regulate the
ratio of to messenger RNA (mRNA) are unknown. In this study,
cloning, sequencing, and splicing analysis of the human and murine
STAT3 genes revealed a highly conserved 5' donor site for generation of
both and mRNA and distinct branch-point sequences,
polypyrimidine tracts, and 3' acceptor sites (ASs) for each. The 3'
AS was found to be located 50 nucleotides downstream of the 3' AS
in exon 23. Two additional cryptic 3' ASs ( and  ) were also
identified. Thus, we identified for the first time the cis
regulatory sequences responsible for generation of STAT3 and
STAT3 mRNA.
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