|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 July 2001, Vol. 98, No. 2, pp. 486-488
BRIEF REPORT
Low frequency of BCL-2/JH translocation in
peripheral blood lymphocytes of healthy Japanese
individuals
Masaki Yasukawa,
Shiro Bando,
Gottfried Dölken,
Eiji Sada,
Yoshihiro Yakushijin,
Shigeru Fujita, and
Hideichi Makino
From the First Department of Internal Medicine, and
Department of Clinical Laboratory Medicine, Ehime University School of
Medicine, Ehime, Japan; Klinik und Poliklinik für Innere
Medizin C, Hämatologie und internistische Onkologie,
Ernst-Moritz-Arndt-Universität, Greifswald, Germany; and
Department of Medical Technology, Ehime Medical College of Health
Science, Ehime, Japan.
The incidence of follicular lymphoma differs significantly between
white and Japanese individuals. Translocation between the BCL-2 and immunoglobulin heavy chain genes is detected in
85% to 90% of all follicular lymphomas in whites. Recently,
BCL-2/JH translocation was detected in
peripheral blood lymphocytes from more than 50% of healthy white
individuals. To clarify the reason for the difference in incidence of
follicular lymphoma between whites and Japanese, the frequency of
BCL-2/JH translocation in peripheral blood
lymphocytes of healthy Japanese individuals was compared with that of
German individuals. The prevalence of BCL-2/JH translocation in Japanese adults appeared to be significantly lower than that in German adults. The present data suggest that the low frequency of BCL-2/JH translocation in
the Japanese general population may be one of the major reasons for the
difference in incidence of follicular lymphoma between whites and Japanese.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. S. Rabkin, C. Hirt, S. Janz, and G. Dolken
t(14;18) Translocations and Risk of Follicular Lymphoma
J Natl Cancer Inst Monographs,
July 1, 2008;
2008(39):
48 - 51.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Dolken, L. Dolken, C. Hirt, C. Fusch, C. S. Rabkin, and F. Schuler
Age-Dependent Prevalence and Frequency of Circulating t(14;18)-Positive Cells in the Peripheral Blood of Healthy Individuals
J Natl Cancer Inst Monographs,
July 1, 2008;
2008(39):
44 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. McHale, Q. Lan, C. Corso, G. Li, L. Zhang, R. Vermeulen, J. D. Curry, M. Shen, R. Turakulov, R. Higuchi, et al.
Chromosome Translocations in Workers Exposed to Benzene
J Natl Cancer Inst Monographs,
July 1, 2008;
2008(39):
74 - 77.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ladetto, D. Drandi, M. Compagno, M. Astolfi, F. Volpato, C. Voena, A. Novarino, B. Pollio, A. Addeo, I. Ricca, et al.
PCR-Detectable Nonneoplastic Bcl-2/IgH Rearrangements Are Common in Normal Subjects and Cancer Patients at Diagnosis but Rare in Subjects Treated With Chemotherapy
J. Clin. Oncol.,
April 1, 2003;
21(7):
1398 - 1403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Dolken, F. Schuler, and G. Dolken
Frequency of BCL-2/JH translocation in healthy males exposed to low-level radiation in comparison to age-matched healthy controls
Blood,
July 30, 2002;
100(4):
1513 - 1514.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Biagi and J. F. Seymour
Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation
Blood,
May 29, 2002;
99(12):
4265 - 4275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
