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Blood, 15 July 2001, Vol. 98, No. 2, pp. 489-491

BRIEF REPORT

Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation

Jan Storek, Denise Wells, Monja A. Dawson, Barry Storer, and David G. Maloney

From the Fred Hutchinson Cancer Research Center, University of Washington, and Hematologics, Seattle, WA.

In 93 allograft recipients, the numbers of marrow B-cell precursors on days 80 and 365 correlated with the counts of circulating B cells, suggesting that the posttransplantation B-cell deficiency is at least in part due to insufficient B lymphopoiesis. Factors that could affect B lymphopoiesis were evaluated. The number of marrow B-cell precursors on days 30 and 80 was at least 4-fold lower in patients with grade 2 to 4 acute graft-versus-host disease (GVHD) compared with patients with grade 0 to 1 acute GVHD. The number of B-cell precursors on day 365 was 18-fold lower in patients with extensive chronic GVHD compared with patients with no or limited chronic GVHD. The number of B-cell precursors was not related to CD34 cell dose, type of transplant (marrow versus blood stem cells), donor age, or patient age. It was concluded that posttransplantation B-cell deficiency results in part from inhibition of B lymphopoiesis by GVHD and/or its treatment.

© 2001 by The American Society of Hematology.
 

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