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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lian, Z. Articles by Weissman, S. M. Search for Related Content PubMed PubMed Citation Articles by Lian, Z. Articles by Weissman, S. M. Related Collections Hematopoiesis and Stem Cells Phagocytes Plenary Papers Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2001, Vol. 98, No. 3, pp. 513-524 PLENARY PAPER Genomic and proteomic analysis of the myeloid differentiation program Zheng Lian, Le Wang, Shigeru Yamaga, Wesley Bonds, Y. Beazer-Barclay, Yuval Kluger, Mark Gerstein, Peter E. Newburger, Nancy Berliner, and Sherman M. Weissman From the Department of Genetics, Boyer Center for Molecular Medicine, the Section of Hematology, Department of Internal Medicine, and the Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT; the Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA; and Gene Logic, Gaithersburg, MD. Although the mature neutrophil is one of the better characterized mammalian cell types, the mechanisms of myeloid differentiation are incompletely understood at the molecular level. A mouse promyelocytic cell line (MPRO), derived from murine bone marrow cells and arrested developmentally by a dominant-negative retinoic acid receptor, morphologically differentiates to mature neutrophils in the presence of 10 µM retinoic acid. An extensive catalog was prepared of the gene expression changes that occur during morphologic maturation. To do this, 3'-end differential display, oligonucleotide chip array hybridization, and 2-dimensional protein electrophoresis were used. A large number of genes whose mRNA levels are modulated during differentiation of MPRO cells were identified. The results suggest the involvement of several transcription regulatory factors not previously implicated in this process, but they also emphasize the importance of events other than the production of new transcription factors. Furthermore, gene expression patterns were compared at the level of mRNA and protein, and the correlation between 2 parameters was studied. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Rithidech, L Honikel, M Milazzo, D Madigan, R Troxell, and L. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020