SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ayroldi, E. Articles by Riccardi, C. Search for Related Content PubMed PubMed Citation Articles by Ayroldi, E. Articles by Riccardi, C. Related Collections Immunobiology Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2001, Vol. 98, No. 3, pp. 743-753 IMMUNOBIOLOGY Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor B Emira Ayroldi, Graziella Migliorati, Stefano Bruscoli, Cristina Marchetti, Ornella Zollo, Lorenza Cannarile, Francesca D'Adamio, and Carlo Riccardi From the Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Perugia, Italy. Previously a novel gene was identified that encodes a glucocorticoid-induced leucine zipper (GILZ) whose expression is up-regulated by dexamethasone. This study analyzed the role of GILZ in the control of T-cell activation and its possible interaction with nuclear factor B (NF-B). Results indicate that GILZ inhibits both T-cell receptor (TCR)-induced interleukin-2/interleukin-2 receptor expression and NF-B activity. In particular, GILZ inhibits NF-B nuclear translocation and DNA binding due to a direct protein-to-protein interaction of GILZ with the NF-B subunits. Moreover, GILZ-mediated modulation of TCR-induced responses is part of a circuit because TCR triggering down-regulates GILZ expression. These results identify a new molecular mechanism involved in the dexamethasone-induced regulation of NF-B activity and T-cell activation. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Crisafulli, S. Bruscoli, E. Esposito, E. Mazzon, R. Di Paola, T. Genovese, P. Bramanti, G. Migliorati, and S. Cuzzocrea PPAR-{alpha} Contributes to the Anti-Inflammatory Activity of 17{beta}-Estradiol J. Pharmacol. Exp. Ther., December 1, 2009; 331(3): 796 - 807. [Abstract] [Full Text] [PDF] S. P. Dudhgaonkar, S. B. Janardhanam, K. N. Kodumudi, and M. Srinivasan CD80 Blockade Enhance Glucocorticoid-Induced Leucine Zipper Expression and Suppress Experimental Autoimmune Encephalomyelitis J. Immunol., December 1, 2009; 183(11): 7505 - 7513. [Abstract] [Full Text] [PDF] E. Ayroldi and C. Riccardi Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action FASEB J, November 1, 2009; 23(11): 3649 - 3658. [Abstract] [Full Text] [PDF] E. M. King, N. S. Holden, W. Gong, C. F. Rider, and R. Newton Inhibition of NF-{kappa}B-dependent Transcription by MKP-1: TRANSCRIPTIONAL REPRESSION BY GLUCOCORTICOIDS OCCURRING VIA p38 MAPK J. Biol. Chem., September 25, 2009; 284(39): 26803 - 26815. [Abstract] [Full Text] [PDF] L. E Ellestad, S. A Malkiewicz, H D. Guthrie, G. R Welch, and T. E Porter Expression and regulation of glucocorticoid-induced leucine zipper in the developing anterior pituitary gland J. Mol. Endocrinol., February 1, 2009; 42(2): 171 - 183. [Abstract] [Full Text] [PDF] S. de Seigneux, V. Leroy, H. Ghzili, M. Rousselot, S. Nielsen, B. C. Rossier, P.-Y. Martin, and E. Feraille NF-{kappa}B Inhibits Sodium Transport via Down-regulation of SGK1 in Renal Collecting Duct Principal Cells J. Biol. Chem., September 12, 2008; 283(37): 25671 - 25681. [Abstract] [Full Text] [PDF] Y. Wang, Y. Lu, D. Yu, Y. Wang, F. Chen, H. Yang, and S. J. Zheng Enhanced Resistance of Restraint-Stressed Mice to Sepsis J. Immunol., September 1, 2008; 181(5): 3441 - 3448. [Abstract] [Full Text] [PDF] W. Zhang, N. Yang, and X.-M. Shi Regulation of Mesenchymal Stem Cell Osteogenic Differentiation by Glucocorticoid-induced Leucine Zipper (GILZ) J. Biol. Chem., February 22, 2008; 283(8): 4723 - 4729. [Abstract] [Full Text] [PDF] R. Soundararajan, J. Wang, D. Melters, and D. Pearce Differential Activities of Glucocorticoid-induced Leucine Zipper Protein Isoforms J. Biol. Chem., December 14, 2007; 282(50): 36303 - 36313. [Abstract] [Full Text] [PDF] S. Ronchetti, G. Nocentini, R. Bianchini, L. T. Krausz, G. Migliorati, and C. Riccardi Glucocorticoid-Induced TNFR-Related Protein Lowers the Threshold of CD28 Costimulation in CD8+ T Cells J. Immunol., November 1, 2007; 179(9): 5916 - 5926. [Abstract] [Full Text] [PDF] H. Hamdi, V. Godot, M.-C. Maillot, M. V. Prejean, N. Cohen, R. Krzysiek, F. M. Lemoine, W. Zou, and D. Emilie Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper Blood, July 1, 2007; 110(1): 211 - 219. [Abstract] [Full Text] [PDF] W. J. E. Tissing, M. L. den Boer, J. P. P. Meijerink, R. X. Menezes, S. Swagemakers, P. J. van der Spek, S. E. Sallan, S. A. Armstrong, and R. Pieters Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells Blood, May 1, 2007; 109(9): 3929 - 3935. [Abstract] [Full Text] [PDF] L. Chiossone, C. Vitale, F. Cottalasso, S. Moretti, B. Azzarone, L. Moretta, and M. C. Mingari Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells Blood, May 1, 2007; 109(9): 3767 - 3775. [Abstract] [Full Text] [PDF] B. D. Marco, M. Massetti, S. Bruscoli, A. Macchiarulo, R. D. Virgilio, E. Velardi, V. Donato, G. Migliorati, and C. Riccardi Glucocorticoid-induced leucine zipper (GILZ)/NF-{kappa}B interaction: role of GILZ homo-dimerization and C-terminal domain Nucleic Acids Res., January 28, 2007; 35(2): 517 - 528. [Abstract] [Full Text] [PDF] L. Rocha-Viegas, G. P. Vicent, J. L. Baranao, M. Beato, and A. Pecci Glucocorticoids Repress bcl-X Expression in Lymphoid Cells by Recruiting STAT5B to the P4 Promoter J. Biol. Chem., November 10, 2006; 281(45): 33959 - 33970. [Abstract] [Full Text] [PDF] N. Cohen, E. Mouly, H. Hamdi, M.-C. Maillot, M. Pallardy, V. Godot, F. Capel, A. Balian, S. Naveau, P. Galanaud, et al. GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response Blood, March 1, 2006; 107(5): 2037 - 2044. [Abstract] [Full Text] [PDF] L. Cannarile, F. Fallarino, M. Agostini, S. Cuzzocrea, E. Mazzon, C. Vacca, T. Genovese, G. Migliorati, E. Ayroldi, and C. Riccardi Increased GILZ expression in transgenic mice up-regulates Th-2 lymphokines Blood, February 1, 2006; 107(3): 1039 - 1047. [Abstract] [Full Text] [PDF] R. Soundararajan, T. T. Zhang, J. Wang, A. Vandewalle, and D. Pearce A Novel Role for Glucocorticoid-induced Leucine Zipper Protein in Epithelial Sodium Channel-mediated Sodium Transport J. Biol. Chem., December 2, 2005; 280(48): 39970 - 39981. [Abstract] [Full Text] [PDF] S. Baumann, A. Dostert, N. Novac, A. Bauer, W. Schmid, S. C. Fas, A. Krueger, T. Heinzel, S. Kirchhoff, G. Schutz, et al. Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer Blood, July 15, 2005; 106(2): 617 - 625. [Abstract] [Full Text] [PDF] M.-L. Asselin-Labat, A. Biola-Vidamment, S. Kerbrat, M. Lombes, J. Bertoglio, and M. Pallardy FoxO3 Mediates Antagonistic Effects of Glucocorticoids and Interleukin-2 on Glucocorticoid-Induced Leucine Zipper Expression Mol. Endocrinol., July 1, 2005; 19(7): 1752 - 1764. [Abstract] [Full Text] [PDF] S. A. Perez, L. G. Mahaira, F. J. Demirtzoglou, P. A. Sotiropoulou, P. Ioannidis, E. G. Iliopoulou, A. D. Gritzapis, N. N. Sotiriadou, C. N. Baxevanis, and M. Papamichail A potential role for hydrocortisone in the positive regulation of IL-15-activated NK-cell proliferation and survival Blood, July 1, 2005; 106(1): 158 - 166. [Abstract] [Full Text] [PDF] D. V. Delfino, M. Agostini, S. Spinicelli, P. Vito, and C. Riccardi Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice Blood, December 15, 2004; 104(13): 4134 - 4141. [Abstract] [Full Text] [PDF] S. N. Georas Inhaled Glucocorticoids, Lymphocytes, and Dendritic Cells in Asthma and Obstructive Lung Diseases Proceedings of the ATS, November 1, 2004; 1(3): 215 - 221. [Abstract] [Full Text] [PDF] M.-L. Asselin-Labat, M. David, A. Biola-Vidamment, D. Lecoeuche, M.-C. Zennaro, J. Bertoglio, and M. Pallardy GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis Blood, July 1, 2004; 104(1): 215 - 223. [Abstract] [Full Text] [PDF] K. De Bosscher, W. Vanden Berghe, and G. Haegeman The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression Endocr. Rev., August 1, 2003; 24(4): 488 - 522. [Abstract] [Full Text] [PDF] P. R. Mittelstadt and J. D. Ashwell Disruption of Glucocorticoid Receptor Exon 2 Yields a Ligand-Responsive C-Terminal Fragment that Regulates Gene Expression Mol. Endocrinol., August 1, 2003; 17(8): 1534 - 1542. [Abstract] [Full Text] [PDF] J. Y. Ji, H. Jing, and S. L. Diamond Shear Stress Causes Nuclear Localization of Endothelial Glucocorticoid Receptor and Expression From the GRE Promoter Circ. Res., February 21, 2003; 92(3): 279 - 285. [Abstract] [Full Text] [PDF] M. C. Marchetti, B. Di Marco, G. Cifone, G. Migliorati, and C. Riccardi Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation Blood, January 15, 2003; 101(2): 585 - 593. [Abstract] [Full Text] [PDF] D. Berrebi, S. Bruscoli, N. Cohen, A. Foussat, G. Migliorati, L. Bouchet-Delbos, M.-C. Maillot, A. Portier, J. Couderc, P. Galanaud, et al. Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10 Blood, January 15, 2003; 101(2): 729 - 738. [Abstract] [Full Text] [PDF] E. Ayroldi, O. Zollo, A. Macchiarulo, B. Di Marco, C. Marchetti, and C. Riccardi Glucocorticoid-Induced Leucine Zipper Inhibits the Raf-Extracellular Signal-Regulated Kinase Pathway by Binding to Raf-1 Mol. Cell. Biol., November 15, 2002; 22(22): 7929 - 7941. [Abstract] [Full Text] [PDF] W. Y. Almawi and O. K. Melemedjian Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor J. Leukoc. Biol., January 1, 2002; 71(1): 9 - 15. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020