|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 August 2001, Vol. 98, No. 4, pp. 1150-1159
NEOPLASIA
Autocrine antiapoptotic stimulation of cultured adult T-cell
leukemia cells by overexpression of the chemokine I-309
Tobias Ruckes,
Domenica Saul,
Jacques Van Snick,
Olivier Hermine, and
Ralph Grassmann
From the Institut für Klinische und Molekulare
Virologie, Erlangen, Germany; Ludwig Institute for Cancer Research,
Brussels Branch, Université Catholique de Louvain, Belgium; and
Department of Clinical Hematology, Hôpital Necker, Paris, France.
Adult T-cell leukemia (ATL) is an aggressive malignancy of
CD4+ T cells caused by the human T-cell leukemia virus type
1 (HTLV-1). The viral leukemogenesis is critically dependent on its
oncoprotein Tax because the protein as well as the virus can
immortalize primary human lymphocytes to permanent growth. As a
transcriptional transactivator, Tax can stimulate the expression of
distinct cellular genes. Alterations in the expression levels of
unknown growth-relevant genes may contribute to the changed growth
properties of Tax-immortalized and leukemic cells. To identify genes
that are linked to Tax transformation and ATL leukemogenesis, this
study systematically compared the gene expression of cultured cells
from patients with acute ATL with that of stimulated peripheral blood T
lymphocytes. Several overexpressed RNAs that encode signal transduction
functions were identified. These include a dual-specific protein
phosphatase (PAC1), an interferon-inducible factor (ISG15), a basic
helix-loop-helix transcription factor (DEC-1), and the secreted
antiapoptotic chemokine I-309. The ATL cell culture supernatants
contained an antiapoptotic activity that could be specifically
inhibited by antibodies directed against I-309. Inhibition of I-309
receptor (CCR8) signaling by pertussis toxin increased the apoptosis
rate of ATL cell cultures in the presence and absence of external
apoptotic stimuli. Both the I-309-specific antiapoptotic activity and
the proapoptotic effect of inhibitors of I-309 signaling suggest the
existence of an antiapoptotic autocrine loop in ATL cells. Thus, the
overexpression of this chemokine may inhibit apoptosis in ATL cells and
could substantially contribute to their growth.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Baba, M. Okamoto, T. Hamasaki, S. Horai, X. Wang, Y. Ito, Y. Suda, and N. Arima
Highly Enhanced Expression of CD70 on Human T-Lymphotropic Virus Type 1-Carrying T-Cell Lines and Adult T-Cell Leukemia Cells
J. Virol.,
April 15, 2008;
82(8):
3843 - 3852.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Hieshima, D. Nagakubo, T. Nakayama, A.-K. Shirakawa, Z. Jin, and O. Yoshie
Tax-Inducible Production of CC Chemokine Ligand 22 by Human T Cell Leukemia Virus Type 1 (HTLV-1)-Infected T Cells Promotes Preferential Transmission of HTLV-1 to CCR4-Expressing CD4+ T Cells
J. Immunol.,
January 15, 2008;
180(2):
931 - 939.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Brown, M. Bellon, and C. Nicot
Emodin and DHA potently increase arsenic trioxide interferon-{alpha}-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1
Blood,
February 15, 2007;
109(4):
1653 - 1659.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Soler, T. R. Chapman, L. R. Poisson, L. Wang, J. Cote-Sierra, M. Ryan, A. McDonald, S. Badola, E. Fedyk, A. J. Coyle, et al.
CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes
J. Immunol.,
November 15, 2006;
177(10):
6940 - 6951.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. N'Diaye, E. Le Ferrec, D. Lagadic-Gossmann, S. Corre, D. Gilot, V. Lecureur, P. Monteiro, C. Rauch, M.-D. Galibert, and O. Fardel
Aryl Hydrocarbon Receptor- and Calcium-dependent Induction of the Chemokine CCL1 by the Environmental Contaminant Benzo[a]pyrene
J. Biol. Chem.,
July 21, 2006;
281(29):
19906 - 19915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Waldele, K. Silbermann, G. Schneider, T. Ruckes, B. R. Cullen, and R. Grassmann
Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes
Blood,
June 1, 2006;
107(11):
4491 - 4499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Krueger, S. C. Fas, M. Giaisi, M. Bleumink, A. Merling, C. Stumpf, S. Baumann, D. Holtkotte, V. Bosch, P. H. Krammer, et al.
HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)
Blood,
May 15, 2006;
107(10):
3933 - 3939.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Gombert, M.-C. Dieu-Nosjean, F. Winterberg, E. Bunemann, R. C. Kubitza, L. Da Cunha, A. Haahtela, S. Lehtimaki, A. Muller, J. Rieker, et al.
CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation
J. Immunol.,
April 15, 2005;
174(8):
5082 - 5091.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Shimauchi, S. Imai, R. Hino, and Y. Tokura
Production of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine by CCR4+ Adult T-Cell Leukemia Cells
Clin. Cancer Res.,
March 15, 2005;
11(6):
2427 - 2435.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Qu, E. W. Edwards, F. Tacke, V. Angeli, J. Llodra, G. Sanchez-Schmitz, A. Garin, N. S. Haque, W. Peters, N. van Rooijen, et al.
Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes
J. Exp. Med.,
November 15, 2004;
200(10):
1231 - 1241.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Waldele, G. Schneider, T. Ruckes, and R. Grassmann
Interleukin-13 Overexpression by Tax Transactivation: a Potential Autocrine Stimulus in Human T-Cell Leukemia Virus-Infected Lymphocytes
J. Virol.,
June 15, 2004;
78(12):
6081 - 6090.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Schaerli, L. Ebert, K. Willimann, A. Blaser, R. S. Roos, P. Loetscher, and B. Moser
A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells
J. Exp. Med.,
May 3, 2004;
199(9):
1265 - 1275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Rao, M. P. Quinones, E. Garavito, Y. Kalkonde, F. Jimenez, C. Gibbons, J. Perez, P. Melby, W. Kuziel, R. L. Reddick, et al.
CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease
J. Immunol.,
November 1, 2003;
171(9):
4875 - 4885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Qiuping, L. Qun, H. Chunsong, Z. Xiaolian, H. Baojun, Y. Mingzhen, L. Chengming, H. Jinshen, G. Qingping, Z. Kejian, et al.
Selectively Increased Expression and Functions of Chemokine Receptor CCR9 on CD4+ T Cells from Patients with T-Cell Lineage Acute Lymphocytic Leukemia
Cancer Res.,
October 1, 2003;
63(19):
6469 - 6477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Ishida, A. Utsunomiya, S. Iida, H. Inagaki, Y. Takatsuka, S. Kusumoto, G. Takeuchi, S. Shimizu, M. Ito, H. Komatsu, et al.
Clinical Significance of CCR4 Expression in Adult T-Cell Leukemia/Lymphoma: Its Close Association with Skin Involvement and Unfavorable Outcome
Clin. Cancer Res.,
September 1, 2003;
9(10):
3625 - 3634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Spinetti, G. Bernardini, G. Camarda, A. Mangoni, A. Santoni, M. C. Capogrossi, and M. Napolitano
The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway
J. Leukoc. Biol.,
January 1, 2003;
73(1):
201 - 207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Pise-Masison, M. Radonovich, R. Mahieux, P. Chatterjee, C. Whiteford, J. Duvall, C. Guillerm, A. Gessain, and J. N. Brady
Transcription Profile of Cells Infected with Human T-cell Leukemia Virus Type I Compared with Activated Lymphocytes
Cancer Res.,
June 1, 2002;
62(12):
3562 - 3571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Haller, Y. Wu, E. Derow, I. Schmitt, K.-T. Jeang, and R. Grassmann
Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein
Mol. Cell. Biol.,
May 15, 2002;
22(10):
3327 - 3338.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
