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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Imagawa, S. Articles by Nagasawa, T. Search for Related Content PubMed PubMed Citation Articles by Imagawa, S. Articles by Nagasawa, T. Related Collections Red Cells Brief Reports Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 August 2001, Vol. 98, No. 4, pp. 1255-1257 BRIEF REPORT Levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea-hypopnea syndrome Shigehiko Imagawa, Yuji Yamaguchi, Masato Higuchi, Tomohiro Neichi, Yuichi Hasegawa, Harumi Y. Mukai, Norio Suzuki, Masayuki Yamamoto, and Toshiro Nagasawa From the Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; Center for Sleep Respiratory Disorder at Fukuoka, Fukuoka, Japan; Chugai Pharmaceutical Co, Ltd, Tokyo, Japan; and Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. To better understand how humans adapt to hypoxia, the levels of hemoglobin (Hb), serum erythropoietin (Epo), and vascular endothelial growth factor (VEGF) were measured in 106 patients with severe obstructive sleep apnea-hypopnea syndrome. The results indicated that temporal hypoxic stimulation increases Hb. Furthermore, a minor increase in Epo and a substantial increase in VEGF were found. The induction in patients with severe sleep apnea was greater than that reported in other types of hypoxia. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Blood levels of vascular endothelial growth factor in obstructive sleep apnea- hypopnea syndrome Eberhard Gunsilius, Andreas L. Petzer, Günther A. Gastl ;, Shigehiko Imagawa, Yuji Yamaguchi, Masato Higuchi, Tomohiro Neichi, Yuichi Hasegawa, Harumi Y Mukai, Norio Suzuki, Masayuki Yamamoto, and Toshiro Nagasawa. Blood 2002 99: 393-394. [Full Text] [PDF] This article has been cited by other articles: J. F. Garvey, C. T. Taylor, and W. T. McNicholas Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation Eur. Respir. J., May 1, 2009; 33(5): 1195 - 1205. [Abstract] [Full Text] [PDF] K. M. Oltmanns, H. Gehring, S. Rudolf, B. Schultes, C. Hackenberg, U. Schweiger, J. Born, H. L. Fehm, and A. Peters Acute hypoxia decreases plasma VEGF concentration in healthy humans Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E434 - E439. [Abstract] [Full Text] [PDF] G. Yuan, J. Nanduri, C. R. Bhasker, G. L. Semenza, and N. R. Prabhakar Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia J. Biol. Chem., February 11, 2005; 280(6): 4321 - 4328. [Abstract] [Full Text] [PDF] T. Yokoe, K. Minoguchi, H. Matsuo, N. Oda, H. Minoguchi, G. Yoshino, T. Hirano, and M. Adachi Elevated Levels of C-Reactive Protein and Interleukin-6 in Patients With Obstructive Sleep Apnea Syndrome Are Decreased by Nasal Continuous Positive Airway Pressure Circulation, March 4, 2003; 107(8): 1129 - 1134. [Abstract] [Full Text] [PDF] K. L. Jones, H. F. Krous, J. Nadeau, B. Blackbourne, H. R. Zielke, and D. Gozal Vascular Endothelial Growth Factor in the Cerebrospinal Fluid of Infants Who Died of Sudden Infant Death Syndrome: Evidence for Antecedent Hypoxia Pediatrics, February 1, 2003; 111(2): 358 - 363. [Abstract] [Full Text] [PDF] C. M. Kahler, J. Wechselberger, C. Molnar, C. Prior, R. Schulz, W. Seeger, and F. Grimminger Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe night time hypoxia Am. J. Respir. Crit. Care Med., January 1, 2003; 167(1): 92 - 93. [Full Text] L. Lavie, H. Kraiczi, A. Hefetz, H. Ghandour, A. Perelman, J. Hedner, and P. Lavie Plasma Vascular Endothelial Growth Factor in Sleep Apnea Syndrome: Effects of Nasal Continuous Positive Air Pressure Treatment Am. J. Respir. Crit. Care Med., June 15, 2002; 165(12): 1624 - 1628. [Abstract] [Full Text] [PDF] E. Gunsilius, A. L. Petzer, G. A. Gastl ;, S. Imagawa, Y. Yamaguchi, M. Higuchi, T. Neichi, Y. Hasegawa, H. Y Mukai, N. Suzuki, et al. Blood levels of vascular endothelial growth factor in obstructive sleep apnea- hypopnea syndrome Blood, January 1, 2002; 99(1): 393 - 394. [Full Text] [PDF]

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