SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lévesque, J.-P. Articles by Simmons, P. J. Search for Related Content PubMed PubMed Citation Articles by Lévesque, J.-P. Articles by Simmons, P. J. Related Collections Hematopoiesis and Stem Cells Plenary Papers Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2001, Vol. 98, No. 5, pp. 1289-1297 PLENARY PAPER Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor Jean-Pierre Lévesque, Yasushi Takamatsu, Susan K. Nilsson, David N. Haylock, and Paul J. Simmons From the Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia. Mobilized progenitor cells currently represent the most commonly used source of hematopoietic progenitor cells (HPCs) to effect hematopoietic reconstitution following myeloablative chemotherapies. Despite their widespread use, the molecular mechanisms responsible for the enforced egress of HPCs from the bone marrow (BM) into the circulation in response to mobilizing agents such as cytokines remain to be determined. Results of this study indicate that expression of vascular cell adhesion molecule-1 (VCAM-1) is strongly reduced in vivo in the BM during HPC mobilization by granulocyte colony-stimulating factor (G-CSF) and stem cell factor. Two serine proteases, namely, neutrophil elastase and cathepsin G, were identified, which cleave VCAM-1 and are released by neutrophils accumulating in the BM during the course of immobilization induced by G-CSF. The proposal is made that an essential step contributing to the mobilization of HPCs is the proteolytic cleavage of VCAM-1 expressed by BM stromal cells, an event triggered by the degranulation of neutrophils accumulating in the BM in response to the administration of G-CSF. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Skokowa, J. P. Fobiwe, L. Dan, B. K. Thakur, and K. Welte Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1 Blood, October 1, 2009; 114(14): 3044 - 3051. [Abstract] [Full Text] [PDF] M. J. Christopher, F. Liu, M. J. Hilton, F. Long, and D. C. Link Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization Blood, August 13, 2009; 114(7): 1331 - 1339. [Abstract] [Full Text] [PDF] K. Horiuchi, T. Kimura, T. Miyamoto, K. Miyamoto, H. Akiyama, H. Takaishi, H. Morioka, T. Nakamura, Y. Okada, C. P. Blobel, et al. Conditional Inactivation of TACE by a Sox9 Promoter Leads to Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF J. Immunol., February 15, 2009; 182(4): 2093 - 2101. [Abstract] [Full Text] [PDF] J. M. Petty, C. C. Lenox, D. J. Weiss, M. E. Poynter, and B. T. Suratt Crosstalk between CXCR4/Stromal Derived Factor-1 and VLA-4/VCAM-1 Pathways Regulates Neutrophil Retention in the Bone Marrow J. Immunol., January 1, 2009; 182(1): 604 - 612. [Abstract] [Full Text] [PDF] S. von Vietinghoff and K. Ley Homeostatic Regulation of Blood Neutrophil Counts J. Immunol., October 15, 2008; 181(8): 5183 - 5188. [Abstract] [Full Text] [PDF] S. Shivtiel, O. Kollet, K. Lapid, A. Schajnovitz, P. Goichberg, A. Kalinkovich, E. Shezen, M. Tesio, N. Netzer, I. Petit, et al. CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules J. Exp. Med., September 29, 2008; 205(10): 2381 - 2395. [Abstract] [Full Text] [PDF] P. C. Maffia, S. E. Zittermann, M. L. Scimone, N. Tateosian, N. Amiano, D. Guerrieri, V. Lutzky, D. Rosso, H. E. Romeo, V. E. Garcia, et al. Neutrophil Elastase Converts Human Immature Dendritic Cells into Transforming Growth Factor-{beta}1-Secreting Cells and Reduces Allostimulatory Ability Am. J. Pathol., September 1, 2007; 171(3): 928 - 937. [Abstract] [Full Text] [PDF] J. M. Shammo and F. M. Stewart Hematopoietic growth factors ASH Self-Assessment Program, January 1, 2007; 2007(1): 45 - 60. [Full Text] [PDF] J. Honold, R. Lehmann, C. Heeschen, D. H. Walter, B. Assmus, K.-I. Sasaki, H. Martin, J. Haendeler, A. M. Zeiher, and S. Dimmeler Effects of Granulocyte Colony Stimulating Factor on Functional Activities of Endothelial Progenitor Cells in Patients With Chronic Ischemic Heart Disease Arterioscler Thromb Vasc Biol, October 1, 2006; 26(10): 2238 - 2243. [Abstract] [Full Text] [PDF] H. K. Kim, M. De La Luz Sierra, C. K. Williams, A. V. Gulino, and G. Tosato G-CSF down-regulation of CXCR4 expression identified as a mechanism for mobilization of myeloid cells Blood, August 1, 2006; 108(3): 812 - 820. [Abstract] [Full Text] [PDF] K. J. Garton, P. J. Gough, and E. W. Raines Emerging roles for ectodomain shedding in the regulation of inflammatory responses J. Leukoc. Biol., June 1, 2006; 79(6): 1105 - 1116. [Abstract] [Full Text] [PDF] M. Condomines, P. Quittet, Z.-Y. Lu, L. Nadal, P. Latry, E. Lopez, M. Baudard, G. Requirand, C. Duperray, J.-F. Schved, et al. Functional Regulatory T Cells Are Collected in Stem Cell Autografts by Mobilization with High-Dose Cyclophosphamide and Granulocyte Colony-Stimulating Factor. J. Immunol., June 1, 2006; 176(11): 6631 - 6639. [Abstract] [Full Text] [PDF] D. G. Woodside, R. M. Kram, J. S. Mitchell, T. Belsom, M. J. Billard, B. W. McIntyre, and P. Vanderslice Contrasting Roles for Domain 4 of VCAM-1 in the Regulation of Cell Adhesion and Soluble VCAM-1 Binding to Integrin {alpha}4beta1. J. Immunol., April 15, 2006; 176(8): 5041 - 5049. [Abstract] [Full Text] [PDF] M. van Pel, R. van Os, G. A. Velders, H. Hagoort, P. M. H. Heegaard, I. J. D. Lindley, R. Willemze, and W. E. Fibbe Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization PNAS, January 31, 2006; 103(5): 1469 - 1474. [Abstract] [Full Text] [PDF] G. Qin, M. Ii, M. Silver, A. Wecker, E. Bord, H. Ma, M. Gavin, D. A. Goukassian, Y.-s. Yoon, T. Papayannopoulou, et al. Functional disruption of {alpha}4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization J. Exp. Med., January 23, 2006; 203(1): 153 - 163. [Abstract] [Full Text] [PDF] C. L. Semerad, M. J. Christopher, F. Liu, B. Short, P. J. Simmons, I. Winkler, J.-P. Levesque, J. Chappel, F. P. Ross, and D. C. Link G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow Blood, November 1, 2005; 106(9): 3020 - 3027. [Abstract] [Full Text] [PDF] Q. Lan, L. Zhang, M. Shen, M. T. Smith, G. Li, R. Vermeulen, S. M. Rappaport, M. S. Forrest, R. B. Hayes, M. Linet, et al. Polymorphisms in Cytokine and Cellular Adhesion Molecule Genes and Susceptibility to Hematotoxicity among Workers Exposed to Benzene Cancer Res., October 15, 2005; 65(20): 9574 - 9581. [Abstract] [Full Text] [PDF] R. Imamura, T. Miyamoto, G. Yoshimoto, K. Kamezaki, F. Ishikawa, H. Henzan, K. Kato, K. Takase, A. Numata, K. Nagafuji, et al. Mobilization of Human Lymphoid Progenitors after Treatment with Granulocyte Colony-Stimulating Factor J. Immunol., August 15, 2005; 175(4): 2647 - 2654. [Abstract] [Full Text] [PDF] T. Ulyanova, L. M. Scott, G. V. Priestley, Y. Jiang, B. Nakamoto, P. A. Koni, and T. Papayannopoulou VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin Blood, July 1, 2005; 106(1): 86 - 94. [Abstract] [Full Text] [PDF] M. Xu, E. Bruno, J. Chao, S. Huang, G. Finazzi, S. M. Fruchtman, U. Popat, J. T. Prchal, G. Barosi, R. Hoffman, et al. Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases Blood, June 1, 2005; 105(11): 4508 - 4515. [Abstract] [Full Text] [PDF] I. G. Winkler, J. Hendy, P. Coughlin, A. Horvath, and J.-P. Levesque Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization J. Exp. Med., April 4, 2005; 201(7): 1077 - 1088. [Abstract] [Full Text] [PDF] A. Aicher, A. M. Zeiher, and S. Dimmeler Mobilizing Endothelial Progenitor Cells Hypertension, March 1, 2005; 45(3): 321 - 325. [Abstract] [Full Text] [PDF] P. C. W. Stone, F. Lally, M. Rahman, E. Smith, C. D. Buckley, G. B. Nash, and G. E. Rainger Transmigrated neutrophils down-regulate the expression of VCAM-1 on endothelial cells and inhibit the adhesion of flowing lymphocytes J. Leukoc. Biol., January 1, 2005; 77(1): 44 - 51. [Abstract] [Full Text] [PDF] M. Wysoczynski, R. Reca, J. Ratajczak, M. Kucia, N. Shirvaikar, M. Honczarenko, M. Mills, J. Wanzeck, A. Janowska-Wieczorek, and M. Z. Ratajczak Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient Blood, January 1, 2005; 105(1): 40 - 48. [Abstract] [Full Text] [PDF] C. T. N. Pham, J. L. Ivanovich, S. Z. Raptis, B. Zehnbauer, and T. J. Ley Papillon-Lefevre Syndrome: Correlating the Molecular, Cellular, and Clinical Consequences of Cathepsin C/Dipeptidyl Peptidase I Deficiency in Humans J. Immunol., December 15, 2004; 173(12): 7277 - 7281. [Abstract] [Full Text] [PDF] M. W. Johansson, M. H. Lye, S. R. Barthel, A. K. Duffy, D. S. Annis, and D. F. Mosher Eosinophils Adhere to Vascular Cell Adhesion Molecule-1 via Podosomes Am. J. Respir. Cell Mol. Biol., October 1, 2004; 31(4): 413 - 422. [Abstract] [Full Text] [PDF] R. M. Rao, T. V. Betz, D. J. Lamont, M. B. Kim, S. K. Shaw, R. M. Froio, F. Baleux, F. Arenzana-Seisdedos, R. Alon, and F. W. Luscinskas Elastase Release by Transmigrating Neutrophils Deactivates Endothelial-bound SDF-1{alpha} and Attenuates Subsequent T Lymphocyte Transendothelial Migration J. Exp. Med., September 20, 2004; 200(6): 713 - 724. [Abstract] [Full Text] [PDF] A. Hidalgo, A. J. Peired, L. A. Weiss, Y. Katayama, and P. S. Frenette The integrin {alpha}M{beta}2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization Blood, August 15, 2004; 104(4): 993 - 1001. [Abstract] [Full Text] [PDF] R. Sun, P. Iribarren, N. Zhang, Y. Zhou, W. Gong, E. H. Cho, S. Lockett, O. Chertov, F. Bednar, T. J. Rogers, et al. Identification of Neutrophil Granule Protein Cathepsin G as a Novel Chemotactic Agonist for the G Protein-Coupled Formyl Peptide Receptor J. Immunol., July 1, 2004; 173(1): 428 - 436. [Abstract] [Full Text] [PDF] J.-P. Levesque, F. Liu, P. J. Simmons, T. Betsuyaku, R. M. Senior, C. Pham, and D. C. Link Characterization of hematopoietic progenitor mobilization in protease-deficient mice Blood, July 1, 2004; 104(1): 65 - 72. [Abstract] [Full Text] [PDF] A. Vroon, C. J. Heijnen, R. Raatgever, I. P. Touw, R. E. Ploemacher, R. T. Premont, and A. Kavelaars GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo J. Leukoc. Biol., April 1, 2004; 75(4): 698 - 704. [Abstract] [Full Text] [PDF] R. E. Young, R. D. Thompson, K. Y. Larbi, M. La, C. E. Roberts, S. D. Shapiro, M. Perretti, and S. Nourshargh Neutrophil Elastase (NE)-Deficient Mice Demonstrate a Nonredundant Role for NE in Neutrophil Migration, Generation of Proinflammatory Mediators, and Phagocytosis in Response to Zymosan Particles In Vivo J. Immunol., April 1, 2004; 172(7): 4493 - 4502. [Abstract] [Full Text] [PDF] C. R. D. Carter, K. M. Whitmore, and R. Thorpe The significance of carbohydrates on G-CSF: differential sensitivity of G-CSFs to human neutrophil elastase degradation J. Leukoc. Biol., March 1, 2004; 75(3): 515 - 522. [Abstract] [Full Text] [PDF] T. Papayannopoulou Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization Blood, March 1, 2004; 103(5): 1580 - 1585. [Abstract] [Full Text] [PDF] L. M. Pelus, H. Bian, A. G. King, and S. Fukuda Neutrophil-derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GRO{beta}/CXCL2 and GRO{beta}T /CXCL2{Delta}4 Blood, January 1, 2004; 103(1): 110 - 119. [Abstract] [Full Text] [PDF] G. A. Velders, R. van Os, H. Hagoort, P. Verzaal, H. F. L. Guiot, I. J. D. Lindley, R. Willemze, G. Opdenakker, and W. E. Fibbe Reduced stem cell mobilization in mice receiving antibiotic modulation of the intestinal flora: involvement of endotoxins as cofactors in mobilization Blood, January 1, 2004; 103(1): 340 - 346. [Abstract] [Full Text] [PDF] F. E. Ouriaghli, E. Sloand, L. Mainwaring, H. Fujiwara, K. Keyvanfar, J. J. Melenhorst, K. Rezvani, G. Sconocchia, S. Solomon, N. Hensel, et al. Clonal dominance of chronic myelogenous leukemia is associated with diminished sensitivity to the antiproliferative effects of neutrophil elastase Blood, November 15, 2003; 102(10): 3786 - 3792. [Abstract] [Full Text] [PDF] K. J. Garton, P. J. Gough, J. Philalay, P. T. Wille, C. P. Blobel, R. H. Whitehead, P. J. Dempsey, and E. W. Raines Stimulated Shedding of Vascular Cell Adhesion Molecule 1 (VCAM-1) Is Mediated by Tumor Necrosis Factor-{alpha}-converting Enzyme (ADAM 17) J. Biol. Chem., September 26, 2003; 278(39): 37459 - 37464. [Abstract] [Full Text] [PDF] J. L. Abkowitz, A. E. Robinson, S. Kale, M. W. Long, and J. Chen Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure Blood, August 15, 2003; 102(4): 1249 - 1253. [Abstract] [Full Text] [PDF] T. Papayannopoulou, G. V. Priestley, H. Bonig, and B. Nakamoto The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization Blood, June 15, 2003; 101(12): 4739 - 4747. [Abstract] [Full Text] [PDF] R. Reca, D. Mastellos, M. Majka, L. Marquez, J. Ratajczak, S. Franchini, A. Glodek, M. Honczarenko, L. A. Spruce, A. Janowska-Wieczorek, et al. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 Blood, May 15, 2003; 101(10): 3784 - 3793. [Abstract] [Full Text] [PDF] J. Sohal, V. T. Phan, P. V. Chan, E. M. Davis, B. Patel, L. M. Kelly, T. J. Abrams, A. M. O'Farrell, D. G. Gilliland, M. M. Le Beau, et al. A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657 Blood, April 15, 2003; 101(8): 3188 - 3197. [Abstract] [Full Text] [PDF] S. Vuckovic, M. Kim, D. Khalil, C. J. Turtle, G. V. Crosbie, N. Williams, L. Brown, K. Williams, C. Kelly, P. Stravos, et al. Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression Blood, March 15, 2003; 101(6): 2314 - 2317. [Abstract] [Full Text] [PDF] F. El Ouriaghli, H. Fujiwara, J. J. Melenhorst, G. Sconocchia, N. Hensel, and A. J. Barrett Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis Blood, March 1, 2003; 101(5): 1752 - 1758. [Abstract] [Full Text] [PDF] M. H. Cottler-Fox, T. Lapidot, I. Petit, O. Kollet, J. F. DiPersio, D. Link, and S. Devine Stem Cell Mobilization Hematology, January 1, 2003; 2003(1): 419 - 437. [Abstract] [Full Text] [PDF] J. G. T. VI, D. C. Tang, S. A. Savage, S. F. Leitman, S. I. Heller, G. R. Serjeant, G. P. Rodgers, and S. J. Chanock Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease Blood, December 15, 2002; 100(13): 4303 - 4309. [Abstract] [Full Text] [PDF] P. A. Zuk, M. Zhu, P. Ashjian, D. A. De Ugarte, J. I. Huang, H. Mizuno, Z. C. Alfonso, J. K. Fraser, P. Benhaim, and M. H. Hedrick Human Adipose Tissue Is a Source of Multipotent Stem Cells Mol. Biol. Cell, December 1, 2002; 13(12): 4279 - 4295. [Abstract] [Full Text] [PDF] M. R. Bonsignore, G. Morici, A. Santoro, M. Pagano, L. Cascio, A. Bonanno, P. Abate, F. Mirabella, M. Profita, G. Insalaco, et al. Circulating hematopoietic progenitor cells in runners J Appl Physiol, November 1, 2002; 93(5): 1691 - 1697. [Abstract] [Full Text] [PDF] C. Carlo-Stella, M. Di Nicola, M. Magni, P. Longoni, M. Milanesi, C. Stucchi, L. Cleris, F. Formelli, and M. A. Gianni Defibrotide in Combination with Granulocyte Colony-stimulating Factor Significantly Enhances the Mobilization of Primitive and Committed Peripheral Blood Progenitor Cells in Mice Cancer Res., November 1, 2002; 62(21): 6152 - 6157. [Abstract] [Full Text] [PDF] G. A. Velders, J. F. M. Pruijt, P. Verzaal, R. van Os, Y. van Kooyk, C. G. Figdor, E.-J. F. M. de Kruijf, R. Willemze, and W. E. Fibbe Enhancement of G-CSF-induced stem cell mobilization by antibodies against the beta 2 integrins LFA-1 and Mac-1 Blood, June 17, 2002; 100(1): 327 - 333. [Abstract] [Full Text] [PDF] A. D. Panopoulos, D. Bartos, L. Zhang, and S. S. Watowich Control of Myeloid-specific Integrin alpha Mbeta 2 (CD11b/CD18) Expression by Cytokines Is Regulated by Stat3-dependent Activation of PU.1 J. Biol. Chem., May 17, 2002; 277(21): 19001 - 19007. [Abstract] [Full Text] [PDF] A. Valenzuela-Fernandez, T. Planchenault, F. Baleux, I. Staropoli, K. Le-Barillec, D. Leduc, T. Delaunay, F. Lazarini, J.-L. Virelizier, M. Chignard, et al. Leukocyte Elastase Negatively Regulates Stromal Cell-derived Factor-1 (SDF-1)/CXCR4 Binding and Functions by Amino-terminal Processing of SDF-1 and CXCR4 J. Biol. Chem., May 3, 2002; 277(18): 15677 - 15689. [Abstract] [Full Text] [PDF] J. F. M. Pruijt, P. Verzaal, R. van Os, E.-J. F. M. de Kruijf, M. L. J. van Schie, A. Mantovani, A. Vecchi, I. J. D. Lindley, R. Willemze, S. Starckx, et al. Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice PNAS, April 30, 2002; 99(9): 6228 - 6233. [Abstract] [Full Text] [PDF] E. A. Sweeney, H. Lortat-Jacob, G. V. Priestley, B. Nakamoto, and T. Papayannopoulou Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells Blood, January 1, 2002; 99(1): 44 - 51. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020