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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Methia, N. Articles by Wagner, D. D. Search for Related Content PubMed PubMed Citation Articles by Methia, N. Articles by Wagner, D. D. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2001, Vol. 98, No. 5, pp. 1424-1428 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Localized reduction of atherosclerosis in von Willebrand factor-deficient mice Nassia Methia, Patrick André, Cécile V. Denis, Maria Economopoulos, and Denisa D. Wagner From the Center for Blood Research and the Department of Pathology, Harvard Medical School, Boston, MA. To examine the role of the platelet adhesion molecule von Willebrand factor (vWf) in atherogenesis, vWf-deficient mice (vWf/) were bred with mice lacking the low-density lipoprotein receptor (LDLR/) on a C57BL/6J background. LDLR/vWf+/+ and LDLR/vWf/ mice were placed on a diet rich in saturated fat and cholesterol for different lengths of time. The atherogenic diet stimulated leukocyte rolling in the mesenteric venules in both genotypes, indicating an increase in P-selectin-mediated adhesion to the endothelium. After 8 weeks on the atherogenic diet, the fatty streaks formed in the aortic sinus of LDLR/vWf/ mice of either sex were 40% smaller and contained fewer monocytes than those in LDLR/vWf+/+ mice. After 22 weeks on the atherogenic diet (early fibrous plaque stage), the difference in lesion size in the aortic sinus persisted. Interestingly, the lesion distribution in the aortas of LDLR/vWf/ animals was different from that of LDLR/ vWf+/+ animals. In vWf-positive mice, half of all lesions were located at the branch points of the renal and mesenteric arteries, whereas lesions in this area were not as prominent in the vWf-negative mice. These results indicate that the absence of vWf primarily affects the regions of the aorta with disturbed flow that are prone to atherosclerosis. Thus, vWf may recruit platelets/leukocytes to the lesion in a flow-dependent manner or may be part of the mechano-transduction pathway regulating endothelial response to shear stress. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Zhu, T. J. Stalker, K. P. Fong, H. Jiang, A. Tran, I. Crichton, E. K. Lee, K. B. Neeves, S. F. Maloney, H. Kikutani, et al. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020