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Blood, 15 September 2001, Vol. 98, No. 6, pp. 1792-1801
HEMATOPOIESIS
The zebrafish klf gene family
Andrew C. Oates,
Stephen J. Pratt,
Brenda Vail,
Yi-lin Yan,
Robert K. Ho,
Stephen L. Johnson,
John H. Postlethwait, and
Leonard I. Zon
From the Howard Hughes Medical Institute, Children's
Hospital, Boston, MA; Ludwig Institute for Cancer Research, Melbourne
Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia;
Department of Molecular Biology, Princeton University, Princeton, NJ;
Department of Genetics, Medical School, Washington University, St.
Louis, MO; and Institute of Neurosciences, University of Oregon,
Eugene.
The Krüppel-like factor
(KLF) family of genes encodes
transcriptional regulatory proteins that play roles in differentiation of a diverse set of cells in mammals. For instance, the founding member
KLF1 (also known as EKLF) is required for
normal globin production in mammals. Five new KLF genes
have been isolated from the zebrafish, Danio rerio, and the
structure of their products, their genetic map positions, and their
expression during development of the zebrafish have been characterized.
Three genes closely related to mammalian KLF2 and
KLF4 were found, as was an ortholog of mammalian
KLF12. A fifth gene, apparently missing from the genome of
mammals and closely related to KLF1 and KLF2,
was also identified. Analysis demonstrated the existence of novel
conserved domains in the N-termini of these proteins. Developmental
expression patterns suggest potential roles for these zebrafish genes
in diverse processes, including hematopoiesis, blood vessel function, and fin and epidermal development. The studies imply a high degree of
functional conservation of the zebrafish genes with their mammalian homologs. These findings further the understanding of the
KLF genes in vertebrate development and indicate an ancient
role in hematopoiesis for the Krüppel-like factor
gene family.
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