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Blood, 15 October 2001, Vol. 98, No. 8, pp. 2568-2570
BRIEF REPORT
Molecular regulation of CC-chemokine receptor 3 expression in
human T helper 2 cells
Emmanuel Scotet,
Susanne Schroeder, and
Antonio Lanzavecchia
From the Basel Institute for Immunology, Basel,
Switzerland.
In developing T helper 1 (Th1) and Th2 cells the acquisition of
effector function is intimately connected with the acquisition of new
migratory capacities, as exemplified by differential expression of
chemokine receptors. This study investigates the molecular mechanisms
responsible for Th2-restricted expression of the CC-chemokine receptor
3 (CCR3). The minimal promoter in T cells was identified in the  149
base pair (bp) upstream sequence that contains a positive regulatory
element. A strong negative element was also localized in the flanking
intronic sequence. The study further investigates the role of chromatin
remodeling in the regulation of this Th2-specific gene. Drugs that
affect the chromatin structure facilitate CCR3 expression in T cells.
Furthermore, in differentiating Th2 cells, selected regions
are associated with acetylated-H3 histones and become more
accessible to DNase I. These results suggest that in Th2 cells both
cytokine production and migratory capacity are regulated through a
similar mechanism involving chromatin remodeling.
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