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Blood, 1 November 2001, Vol. 98, No. 9, pp. 2603-2614
REVIEW ARTICLE
Cellular stress response and apoptosis in cancer therapy
Ingrid Herr and
Klaus-Michael Debatin
From the Division of Pediatric Oncology, German Cancer
Research Center, Heidelberg, Germany; and University Children's
Hospital, Ulm, Germany.
Anticancer treatment using cytotoxic drugs is considered to
mediate cell death by activating key elements of the apoptosis program
and the cellular stress response. While proteolytic enzymes (caspases)
serve as main effectors of apoptosis, the mechanisms involved in
activation of the caspase system are less clear. Two distinct pathways
upstream of the caspase cascade have been identified. Death receptors,
eg, CD95 (APO-1/Fas), trigger caspase-8, and mitochondria release
apoptogenic factors (cytochrome c, Apaf-1, AIF), leading to the
activation of caspase-9. The stressed endoplasmic reticulum
(ER) contributes to apoptosis by the unfolded protein response pathway,
which induces ER chaperones, and by the ER overload response pathway,
which produces cytokines via nuclear factor- B. Multiple other
stress-inducible molecules, such as p53, JNK, AP-1, NF-B,
PKC/MAPK/ERK, and members of the sphingomyelin pathway have a profound
influence on apoptosis. Understanding the complex interaction between
different cellular programs provides insights into sensitivity or
resistance of tumor cells and identifies molecular targets for rational
therapeutic intervention strategies.
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R. Wang, C. Li, D. Song, G. Zhao, L. Zhao, and Y. Jing
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|
|
|
|
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|
|
|
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67(12):
5865 - 5871.
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|
|
|
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|
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|
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|
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|
|
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|
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J. Choi, Y. K. Hwang, K. W. Sung, S. H. Lee, K. H. Yoo, H. L. Jung, H. H. Koo, H.-J. Kim, H. J. Kang, H. Y. Shin, et al.
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|
|
|
|
|
|
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|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
S. Mishra, J. P. Mishra, K. Gee, D. C. McManus, E. C. LaCasse, and A. Kumar
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280(45):
37536 - 37546.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Broker, F. A.E. Kruyt, and G. Giaccone
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11(9):
3155 - 3162.
[Abstract]
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|
|
|
|
|
|
|
X. Ke, R. A. McKnight, Z.-m. Wang, X. Yu, L. Wang, C. W. Callaway, K. H. Albertine, and R. H. Lane
Nonresponsiveness of cerebral p53-MDM2 functional circuit in newborn rat pups rendered IUGR via uteroplacental insufficiency
Am J Physiol Regulatory Integrative Comp Physiol,
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288(4):
R1038 - R1045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Hauptschein, K. E. Sloan, C. Torella, R. Moezzifard, M. Giel-Moloney, C. Zehetmeier, C. Unger, L. L. Ilag, and D. G. Jay
Functional Proteomic Screen Identifies a Modulating Role for CD44 in Death Receptor-Mediated Apoptosis
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65(5):
1887 - 1896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Long, C. M. H. Colitz, and J. A. Bomser
Apoptotic and Necrotic Mechanisms of Stress-Induced Human Lens Epithelial Cell Death
Experimental Biology and Medicine,
November 1, 2004;
229(10):
1072 - 1080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kasibhatla, H. Gourdeau, K. Meerovitch, J. Drewe, S. Reddy, L. Qiu, H. Zhang, F. Bergeron, D. Bouffard, Q. Yang, et al.
Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity
Mol. Cancer Ther.,
November 1, 2004;
3(11):
1365 - 1374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zou, X. Liu, P. Yue, Z. Zhou, M. B. Sporn, R. Lotan, F. R. Khuri, and S.-Y. Sun
c-Jun NH2-Terminal Kinase-Mediated Up-regulation of Death Receptor 5 Contributes to Induction of Apoptosis by the Novel Synthetic Triterpenoid Methyl-2-Cyano-3,12-Dioxooleana-1, 9-Dien-28-Oate in Human Lung Cancer Cells
Cancer Res.,
October 15, 2004;
64(20):
7570 - 7578.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Kondoh, I. Suzuki, M. Sato, F. Nagashima, S. Simizu, M. Harada, M. Fujii, H. Osada, Y. Asakawa, and Y. Watanabe
Kaurene Diterpene Induces Apoptosis in Human Leukemia Cells Partly through a Caspase-8-Dependent Pathway
J. Pharmacol. Exp. Ther.,
October 1, 2004;
311(1):
115 - 122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. J. Weston, B. Austen, W. Wei, E. Marston, A. Alvi, S. Lawson, P. J. Darbyshire, M. Griffiths, F. Hill, J. R. Mann, et al.
Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-{kappa}B survival pathway signaling
Blood,
September 1, 2004;
104(5):
1465 - 1473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Bayon, M. A. Ortiz, F. J. Lopez-Hernandez, P. H. Howe, and F. J. Piedrafita
The Retinoid Antagonist MX781 Induces Clusterin Expression in Prostate Cancer Cells via Heat Shock Factor-1 and Activator Protein-1 Transcription Factors
Cancer Res.,
August 15, 2004;
64(16):
5905 - 5912.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Thyrell, L. Hjortsberg, V. Arulampalam, T. Panaretakis, S. Uhles, M. Dagnell, B. Zhivotovsky, I. Leibiger, D. Grander, and K. Pokrovskaja
Interferon {alpha}-induced Apoptosis in Tumor Cells Is Mediated through the Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Signaling Pathway
J. Biol. Chem.,
June 4, 2004;
279(23):
24152 - 24162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Grassilli, A. Ballabeni, E. Maellaro, B. Del Bello, and K. Helin
Loss of MYC Confers Resistance to Doxorubicin-induced Apoptosis by Preventing the Activation of Multiple Serine Protease- and Caspase-mediated Pathways
J. Biol. Chem.,
May 14, 2004;
279(20):
21318 - 21326.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Conticello, F. Pedini, A. Zeuner, M. Patti, M. Zerilli, G. Stassi, A. Messina, C. Peschle, and R. De Maria
IL-4 Protects Tumor Cells from Anti-CD95 and Chemotherapeutic Agents via Up-Regulation of Antiapoptotic Proteins
J. Immunol.,
May 1, 2004;
172(9):
5467 - 5477.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Decker, M. Oelsner, R. J. Kreitman, G. Salvatore, Q.-c. Wang, I. Pastan, C. Peschel, and T. Licht
Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins
Blood,
April 1, 2004;
103(7):
2718 - 2726.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Nagel-Wolfrum, C. Buerger, I. Wittig, K. Butz, F. Hoppe-Seyler, and B. Groner
The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor Stat3 Inhibits Transactivation and Induces Apoptosis in Tumor Cells
Mol. Cancer Res.,
March 1, 2004;
2(3):
170 - 182.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. FADEEL, S. ORRENIUS, and S. PERVAIZ
Buried alive: a novel approach to cancer treatment
FASEB J,
January 1, 2004;
18(1):
1 - 4.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. E. Broker, C. Huisman, S. W. Span, J. A. Rodriguez, F. A. E. Kruyt, and G. Giaccone
Cathepsin B Mediates Caspase-Independent Cell Death Induced by Microtubule Stabilizing Agents in Non-Small Cell Lung Cancer Cells
Cancer Res.,
January 1, 2004;
64(1):
27 - 30.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Yi, J. Yang, R. He, F. Gao, H. Sang, X. Tang, and R. D. Ye
Emodin Enhances Arsenic Trioxide-Induced Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Survival Signaling
Cancer Res.,
January 1, 2004;
64(1):
108 - 116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fulda and K.-M. Debatin
Sensitization for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by the Chemopreventive Agent Resveratrol
Cancer Res.,
January 1, 2004;
64(1):
337 - 346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. M. Dirsch, I. M. Muller, S. T. Eichhorst, G. R. Pettit, Y. Kamano, M. Inoue, J.-P. Xu, Y. Ichihara, G. Wanner, and A. M. Vollmar
Cephalostatin 1 Selectively Triggers the Release of Smac/DIABLO and Subsequent Apoptosis That Is Characterized by an Increased Density of the Mitochondrial Matrix
Cancer Res.,
December 15, 2003;
63(24):
8869 - 8876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Kalli, K. E. Devine, M. C. Cabot, C. R. Arnt, M. P. Heldebrant, P. A. Svingen, C. Erlichman, L. C. Hartmann, C. A. Conover, and S. H. Kaufmann
Heterogeneous Role of Caspase-8 in Fenretinide-Induced Apoptosis in Epithelial Ovarian Carcinoma Cell Lines
Mol. Pharmacol.,
December 1, 2003;
64(6):
1434 - 1443.
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