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Blood, 1 November 2001, Vol. 98, No. 9, pp. 2778-2783
NEOPLASIA
Interleukin-7 and interleukin-15 regulate the expression of the
bcl-2 and c-myb genes in cutaneous T-cell
lymphoma cells
Jian-Zhong Qin,
Chun-Lei Zhang,
Jivko Kamarashev,
Reinhard Dummer,
Günter Burg, and
Udo Döbbeling
From the Department of Dermatology, University Hospital
of Zurich, Switzerland.
Interleukin-7 (IL-7) and IL-15 have been recently identified
as growth factors for cutaneous T-cell lymphoma (CTCL) cells, and they
protect these cells from cell death. Using the CTCL cell line SeAx as a
test system now shows that IL-7 and IL-15 are indeed necessary to
maintain high levels of bcl-2. The up-regulation of bcl-2 was
paralleled by increased DNA-binding activities of the transcription
factors STAT2, STAT5, STAT6, and c-Myb to bcl-2 gene promoter-enhancer elements. Because STAT5 and c-Myb positively regulate bcl-2, IL-7 and IL-15 may mediate some of their effects on
cell death survival gene expression through these 2 factors. Constitutive activities of the 3 STAT factors and c-Myb were found in
the IL-7- and IL-15-independent CTCL cell lines HUT78 and MyLa 2059. The c-Myb protein was also present in CTCL cells of the skin lesions of all investigated patients. These results indicate that
IL-7 and IL-15 may increase bcl-2 expression in CTCL cells by the
activation of c-myb and STAT factors.
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