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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Urban, B. C. Articles by Roberts, D. J. Search for Related Content PubMed PubMed Citation Articles by Urban, B. C. Articles by Roberts, D. J. Related Collections Immunobiology Red Cells Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 November 2001, Vol. 98, No. 9, pp. 2859-2861 BRIEF REPORT Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria Britta C. Urban, Tabitha Mwangi, Amanda Ross, Samson Kinyanjui, Moses Mosobo, Oscar Kai, Brett Lowe, Kevin Marsh, and David J. Roberts From the Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, and National Blood Service, John Radcliffe Hospital, University of Oxford, United Kingdom; and Wellcome Trust Research Laboratories/KEMRI, Kilifi, Kenya. The importance of dendritic cells (DCs) for the initiation and regulation of immune responses not only to foreign organisms but also to the self has raised considerable interest in the qualitative and quantitative analysis of these cells in various human diseases. Plasmodium falciparum malaria is characterized by the poor induction of long-lasting protective immune responses. This study, therefore, investigated the percentage of peripheral blood DCs as lineage marker-negative and HLA-DR+ or CD83+ cells in healthy children and in children suffering from acute malaria in Kilifi, Kenya. Comparable percentages of CD83+ DCs were found in peripheral blood of healthy children and children with malaria. However, the percentage of HLA-DR+ peripheral blood DCs was significantly reduced in children with malaria. The results suggest that a proportion of peripheral blood DCs may be functionally impaired due to the low expression of HLA-DR on their surface. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Mukherjee and V. S. Chauhan Plasmodium falciparum-free merozoites and infected RBCs distinctly affect soluble CD40 ligand-mediated maturation of immature monocyte-derived dendritic cells J. Leukoc. Biol., July 1, 2008; 84(1): 244 - 254. [Abstract] [Full Text] [PDF] K. A. Wong and A. Rodriguez Plasmodium Infection and Endotoxic Shock Induce the Expansion of Regulatory Dendritic Cells J. Immunol., January 15, 2008; 180(2): 716 - 726. [Abstract] [Full Text] [PDF] B. C. Urban, D. Cordery, M. J. Shafi, P. C. Bull, C. I. Newbold, T. N. Williams, and K. Marsh The Frequency of BDCA3-Positive Dendritic Cells Is Increased in the Peripheral Circulation of Kenyan Children with Severe Malaria Infect. Immun., December 1, 2006; 74(12): 6700 - 6706. [Abstract] [Full Text] [PDF] L. P. Breitling, R. Fendel, B. Mordmueller, A. A. Adegnika, P. G. Kremsner, and A. J. F. Luty Cord Blood Dendritic Cell Subsets in African Newborns Exposed to Plasmodium falciparum In Utero. Infect. Immun., October 1, 2006; 74(10): 5725 - 5729. [Abstract] [Full Text] [PDF] C. C. Keller, O. Yamo, C. Ouma, J. M. Ong'echa, D. Ounah, J. B. Hittner, J. M. Vulule, and D. J. Perkins Acquisition of Hemozoin by Monocytes Down-Regulates Interleukin-12 p40 (IL-12p40) Transcripts and Circulating IL-12p70 through an IL-10-Dependent Mechanism: In Vivo and In Vitro Findings in Severe Malarial Anemia Infect. Immun., September 1, 2006; 74(9): 5249 - 5260. [Abstract] [Full Text] [PDF] B. C. URBAN, M. J. SHAFI, D. V. CORDERY, A. MACHARIA, B. LOWE, K. MARSH, and T. N. WILLIAMS FREQUENCIES OF PERIPHERAL BLOOD MYELOID CELLS IN HEALTHY KENYAN CHILDREN WITH {alpha}+ THALASSEMIA AND THE SICKLE CELL TRAIT Am J Trop Med Hyg, April 1, 2006; 74(4): 578 - 584. [Abstract] [Full Text] [PDF] A. VALDERRAMA-AGUIRRE, G. QUINTERO, A. GOMEZ, A. CASTELLANOS, Y. PEREZ, F. MENDEZ, M. AREVALO-HERRERA, and S. HERRERA ANTIGENICITY, IMMUNOGENICITY, AND PROTECTIVE EFFICACY OF PLASMODIUM VIVAX MSP1 PV200L: A POTENTIAL MALARIA VACCINE SUBUNIT Am J Trop Med Hyg, November 1, 2005; 73(5_suppl): 16 - 24. [Abstract] [Full Text] [PDF] B. C. Urban, T. T. Hien, N. P. Day, N. H. Phu, R. Roberts, E. Pongponratn, M. Jones, N. T. H. Mai, D. Bethell, G. D. H. Turner, et al. Fatal Plasmodium falciparum Malaria Causes Specific Patterns of Splenic Architectural Disorganization Infect. Immun., April 1, 2005; 73(4): 1986 - 1994. [Abstract] [Full Text] [PDF] D. S. Pouniotis, O. Proudfoot, V. Bogdanoska, V. Apostolopoulos, T. Fifis, and M. Plebanski Dendritic Cells Induce Immunity and Long-Lasting Protection against Blood-Stage Malaria despite an In Vitro Parasite-Induced Maturation Defect Infect. Immun., September 1, 2004; 72(9): 5331 - 5339. [Abstract] [Full Text] [PDF] S. Mahanty, A. Saul, and L. H. Miller Progress in the development of recombinant and synthetic blood-stage malaria vaccines J. Exp. Biol., November 1, 2003; 206(21): 3781 - 3788. [Abstract] [Full Text] [PDF]

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